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Genotyping Influenza Virus by Next-Generation Deep Sequencing in Clinical Specimens

Seong MW, Cho SI, Park H, Seo SH, Lee SJ, Kim EC, Park SS

Rapid and accurate identification of an influenza outbreak is essential for patient care and treatment. We describe a next-generation sequencing (NGS)-based, unbiased deep sequencing method in clinical specimens to investigate...
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Viral loads and E2/NS1 region sequences of hepatitis C virus in hepatocellular carcinoma and surrounding liver

Park CK, Park TR, Kim YB, Kim HY, Yoo JY, Kim CH, Choo SH, Cho JM

  • KMID: 1038874
  • Korean J Intern Med.
  • 1997 Jan;12(1):28-33.
OBJECTIVES: Numerous epidemiologic data have documented that chronic infection by hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). But the molecular mechanism...
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Genotype-4 hepatitis E in a human after ingesting roe deer meat in South Korea

Choi JY, Lee JM, Jo YW, Min HJ, Kim HJ, Jung WT, Lee OJ, Yun H, Yoon YS

The recent increase in the number of cases of indigenous hepatitis E virus (HEV) infection highlights the importance of identifying the transmission routes for the prevention of such infections. Presented...
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EBV in situ hybridization study for non-Hodgkin's lymphomas

Ko YH, Lee JD

Epstein-Barr virus(EBV) has been implicated in the pathogenesis of B-lymphoproliferative disorders, T-cell lymphomas and Hodgkin's disease. In this report, we performed an in situ hybridization study on EBV genome in...
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Predicting factors of present hepatitis C virus infection among patients positive for the hepatitis C virus antibody

Lee CH, Shin HP, Lee JI, Joo KR, Cha JM, Jeon JW, Lim JU, Min JK, Kim DH, Kang SW, Joung HJ

BACKGROUND/AIMS: To identify the predicting factors of present hepatitis C virus (HCV) infection among patients with positivity for antibodies to HCV (anti-HCV). METHODS: We analyzed patients who showed positive enzyme immunoassay...
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Hepatitis G virus infection in hemodialysis and continuous ambulatory peritoneal dialysis patients

Noh H, Kang SW, Choi SH, Shin SK, Seo BJ, Lee IH, Choi KH, Han DS, Kim HS, Lee HY

To determine the prevalence and clinical relevance of HGV infection in dialysis patients, we performed a cross-sectional study of 61 HD patients and 79 Continuous Ambulatory Peritoneal Dialysis (CAPD) patients....
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Comparison of 3 Automated Immunoassays for Detection of Anti-Hepatitis A Virus Immunoglobulin M in a Tertiary Care Hospital

Park H, Lee YJ, Seong MW, Lee DH, Park MH, Song EY

Three automated immunoassay kits for anti-Hepatitis A Virus (HAV) IgM-Architect, (Abbott Laboratories, USA), Elecsys (Roche Diagnostics, Germany), and ADVIA Centaur (Siemens Healthcare Diagnostics Inc., USA)-were compared. We included 178 consecutive...
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In vitro Culture of Hepatitis C Virus (HCV) Using Immortalized Hepatocyte

Choi JE, Hur W, Shin JY, Piao LS, Yoon SK

  • KMID: 1767619
  • Korean J Gastroenterol.
  • 2008 Sep;52(3):150-160.
BACKGROUND/AIMS: It is essential to develop an in vitro culture model of primary hepatocytes for the study of hepatocellular function and the pathogenesis of hepatitis C virus (HCV) infection. In...
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Advancement in in vitro Culture System of Hepatitis C Virus Replication

Kim DG

  • KMID: 1767626
  • Korean J Gastroenterol.
  • 2008 Sep;52(3):196-199.
No abstract available.
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Epidemiological Investigation of an Outbreak of Hepatitis A at a Residential Facility for the Disabled, 2011

Lim HS, Choi K, Lee S

  • KMID: 1501682
  • J Prev Med Public Health.
  • 2013 Mar;46(2):62-73.
OBJECTIVES: An outbreak of hepatitis A occurred at a residential facility for the disabled in July 10, 2011. This investigation was carried out to develop a response plan, and to...
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Isolation of Middle East Respiratory Syndrome Coronavirus from a Patient of the 2015 Korean Outbreak

Park WB, Kwon NJ, Choe PG, Choi SJ, Oh HS, Lee SM, Chong H, Kim JI, Song KH, Bang JH, Kim ES, Kim HB, Park SW, Kim NJ, Oh MD

During the 2015 outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Korea, 186 persons were infected, resulting in 38 fatalities. We isolated MERS-CoV from the oropharyngeal sample obtained from...
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Recent trends in the treatment of chronic hepatitis C

Jun DW, Tak WY, Bae SH, Lee YJ

Pegylated interferon and ribavirin combination therapy is accepted as the standard antiviral treatment for chronic hepatitis C regardless of HCV genotype. This combination therapy achieves higher response rates than previous...
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Prevalence of Hepatitis C Virus Infections and Distribution of Hepatitis C Virus Genotypes among Korean Blood Donors

Oh DJ, Park YM, Seo YI, Lee JS, Lee JY

BACKGROUND: Hepatitis C virus (HCV) remains a worldwide health-care burden. Prevalence rates vary and the distribution of genotypes depends on geographical location. Here, the recent prevalence of HCV infections and...
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Comparative Evaluation of Three Homogenization Methods for Isolating Middle East Respiratory Syndrome Coronavirus Nucleic Acids From Sputum Samples for Real-Time Reverse Transcription PCR

Sung H, Yong D, Ki CS, Kim JS, Seong MW, Lee H, Kim MN

BACKGROUND: Real-time reverse transcription PCR (rRT-PCR) of sputum samples is commonly used to diagnose Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Owing to the difficulty of extracting RNA from sputum...
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Co-circulation of Two Genotypes of Hepatitis A Virus from Sporadic Cases in Northeastern Area of Seoul, Korea

Yoo SJ, Seo DD, Choi WC, Kwon OJ, Park JC, Shin BM

BACKGROUND: In previous studies, most hepatitis A virus (HAV) isolates had been genotype IA in Korea. Recently, a small number of different genotypes were reported with an upsurge of acute...
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Biophysical characterization of Japanese encephalitis virus (KV1899) isolated from pigs in Korea

Yang DK, Kim BH, Kweon CH, Kwon JH, Lim SI, Han HR

  • KMID: 1120068
  • J Vet Sci.
  • 2004 Jun;5(2):125-130.
A virus strain, showing cytopathic effect in Vero cell, was isolated from plasma of a fattening pig in Gyeonggi province, Korea in October 1999. The evaluation of physicochemical/biological properties of...
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First Imported Case of Zika Virus Infection into Korea

Jang HC, Park WB, Kim UJ, Chun JY, Choi SJ, Choe PG, Jung SI, Jee Y, Kim NJ, Choi EH, Oh MD

Since Zika virus has been spreading rapidly in the Americas from 2015, the outbreak of Zika virus infection becomes a global health emergency because it can cause neurological complications and...
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Evaluation of an Immunochromatographic Assay for the Rapid and Simultaneous Detection of Rotavirus and Adenovirus in Stool Samples

Kim J, Kim HS, Kim HS, Kim JS, Song W, Lee KM, Lee S, Park KU, Lee W, Hong YJ

BACKGROUND: We evaluated the analytical and clinical performances of the SD BIOLINE Rota/Adeno Rapid kit (SD Rota/Adeno Rapid; Standard Diagnostics, Inc., Korea), an immunochromatographic assay (ICA), for the simultaneous detection...
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Advanced fibrosis is not a negative pretreatment predictive factor for genotype 2 or 3 chronic hepatitis C patients

Lee HS, Kweon YO, Tak WY, Park SY, Kang EJ, Lee YL, Yang HM, Park HW

BACKGROUND/AIMS: Chronic hepatitis C patients with advanced fibrosis have unsatisfactory sustained virological response (SVR) rates. Few data demonstrating the efficacy of combination therapy in chronic hepatitis C patients with advanced...
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Differences in the patterns and outcomes of enhanced viral replication between hepatitis C virus and hepatitis B virus in patients with hepatocellular carcinoma during transarterial chemolipiodolization

Sung PS, Bae SH, Jang JW, Song DS, Kim HY, Yoo SH, Park CH, Kwon JH, Song MJ, You CR, Choi JY, Yoon SK

BACKGROUND/AIMS: Enhanced replication of hepatitis C virus (HCV) is well described in the setting of moderate to severe immunosuppression. The aims of this retrospective study were to determine the incidence...
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