Clin Mol Hepatol.  2013 Jun;19(2):148-155. 10.3350/cmh.2013.19.2.148.

Advanced fibrosis is not a negative pretreatment predictive factor for genotype 2 or 3 chronic hepatitis C patients

• Lee HS
• Kweon YO
• Tak WY
• Park SY
• Kang EJ
• Lee YL
• Yang HM
• Park HW

• KMID: 1776802
• DOI: http://doi.org/10.3350/cmh.2013.19.2.148

Abstract

BACKGROUND/AIMS
Chronic hepatitis C patients with advanced fibrosis have unsatisfactory sustained virological response (SVR) rates. Few data demonstrating the efficacy of combination therapy in chronic hepatitis C patients with advanced fibrosis in South Korea are available. The purpose of this study was to assess whether the stage of fibrosis impacts the efficacy of combination therapy for chronic hepatitis C.
METHODS
We retrospectively reviewed data for a total of 109 patients with chronic hepatitis C, treated with peginterferon alfa and ribavirin. SVR according to the stage of liver fibrosis assessed by pretreatment liver biopsy and genotype results were analyzed.
RESULTS
Data from 66 genotype 1 patients (60.6%) and 43 genotype 2 or 3 patients (39.4%) among the 109 patients were analyzed. SVR rates for the genotype 1 patients were significantly lower for the stage 3-4 group (32.1%) than the stage 0-2 group (78.9%; P<0.001). SVR rates (92.0% for stage 0-2, 77.8% for stage 3-4, P=0.184) of genotype 2 or 3 patients were not significantly different according to fibrosis stage. Likewise, the frequency of adverse events was not significantly different according to fibrosis stage.
CONCLUSIONS
Compared to patients without advanced fibrosis, we can anticipate good SVR rates for genotype 2 or 3 patients with advanced fibrosis and they did not show an inferior tolerability for peginterferon and ribavirin combination therpy. Our results suggest that active treatment is needed for genotype 2 or 3 patients with advanced fibrosis.

Keyword

Hepatitis C; Advanced fibrosis; Genotype

MeSH Terms

Adult
Age Factors
Antiviral Agents/therapeutic use
Blood Platelets/cytology
Drug Therapy, Combination
Female
Genotype
Hepacivirus/genetics
Hepatitis C, Chronic/complications/*drug therapy/genetics
Humans
Interferon-alpha/therapeutic use
Liver Cirrhosis/complications/*pathology
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Polyethylene Glycols/therapeutic use
RNA, Viral/analysis
Recombinant Proteins/therapeutic use
Retrospective Studies
Ribavirin/therapeutic use
Severity of Illness Index
Treatment Outcome
Antiviral Agents
Interferon-alpha
Polyethylene Glycols
RNA, Viral
Recombinant Proteins
Ribavirin