Clin Mol Hepatol.  2013 Dec;19(4):376-381. 10.3350/cmh.2013.19.4.376.

Predicting factors of present hepatitis C virus infection among patients positive for the hepatitis C virus antibody

• Lee CH
• Shin HP
• Lee JI
• Joo KR
• Cha JM
• Jeon JW
• Lim JU
• Min JK
• Kim DH
• Kang SW
• Joung HJ

• KMID: 1730883
• DOI: http://doi.org/10.3350/cmh.2013.19.4.376

Abstract

BACKGROUND/AIMS
To identify the predicting factors of present hepatitis C virus (HCV) infection among patients with positivity for antibodies to HCV (anti-HCV).
METHODS
We analyzed patients who showed positive enzyme immunoassay (EIA) results and performed an HCV RNA test as a confirmatory test at Kyung Hee University Hospital at Gangdong from June 2006 to July 2012. The features distinguishing the groups with positive and negative HCV RNA results were reviewed.
RESULTS
In total, 490 patients were included. The results of the HCV RNA test were positive and negative in 228 and 262 patients, respectively. The index value of anti-HCV, mean age, platelet counts, total bilirubin, prothrombin time international normalized ratio, albumin and alanine transaminase (ALT) levels differed significantly between the two groups. On multivariable analysis, an index value of anti-HCV >10 [odds ratio (OR)=397.27, P<0.001), ALT >40 IU/L (OR=3.64, P=0.001), and albumin <3.8 g/dL (OR=2.66, P=0.014) were related to present HCV infection.
CONCLUSIONS
Although EIA is not a quantitative test, considering the anti-HCV titer with ALT and albumin levels may be helpful in predicting present of HCV infection.

Keyword

Hepatitis C; Hepatitis C Antibodies; Diagnosis; Immunoassay

MeSH Terms

Adult
Aged
Alanine Transaminase/blood
Bilirubin/blood
Female
Hepacivirus/genetics
Hepatitis C/*diagnosis
Hepatitis C Antibodies/*blood
Humans
Immunoenzyme Techniques
Male
Middle Aged
Odds Ratio
Platelet Count
Predictive Value of Tests
RNA, Viral/analysis
Serum Albumin/analysis
Alanine Transaminase
Bilirubin
Hepatitis C Antibodies
RNA, Viral
Serum Albumin