- Differential Expression of the Tight Junction Protein, Occludin, in Brain Tumors
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Kim CH, Cheong JH, Bak KH, Kim JM, Ko Y, Oh SJ
- KMID: 2067195
- J Korean Neurosurg Soc.
- 2005 Jul;38(1):12-15.
OBJECTIVE: Cerebral edema develops in the brain tumors by loosening of the endothelial tight junction. Tight junction(TJ) proteins, such as occludin and claudin bind adjacent cells tightly. Authors examine the... -
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- Regional Variation in the Expression of 'Tight Junction' Protein 'Occludin' in the Epidermis
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Yoo SR, Kim JS, Ko JY, Lee CW
- KMID: 2302105
- Korean J Dermatol.
- 2008 Feb;46(2):196-201.
BACKGROUND: 'Tight junctions (TJ)' have recently been identified in the granular cell layer of the human epidermis, where they contribute to the normal adhesion between keratinocytes and to the physiologic... -
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- Expression of Occludin in Porcine Renal Epithelial Cells
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Lee SY, Han KH
- KMID: 1472503
- Korean J Anat.
- 2009 Mar;42(1):11-17.
Occludin is a cell adhesion molecule that is abundantly expressed in the kidney. However, the expression pattern in various renal epithelial cells is not well established. The purpose of this... -
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- Occludin Expression in Brain Tumors and its Relevance to Peritumoral Edema and Survival
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Park MW, Kim CH, Cheong JH, Bak KH, Kim JM, Oh SJ
- KMID: 2166058
- Cancer Res Treat.
- 2006 Jun;38(3):139-143.
PURPOSE: Peritumoral brain edema (PTBE) is a serious causative factor that contributes the morbidity or mortality of brain tumors. The development of PTBE is influenced by many factors, including such... -
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- Effects of High Glucose and Dexamethasone on the Permeability in Trabecular Meshwork Cells
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Kang SH, Kim JW
- KMID: 2406960
- J Korean Ophthalmol Soc.
- 2018 Mar;59(3):252-260.
- doi: 10.3341/jkos.2018.59.3.252
PURPOSE: To investigate the effects of high glucose (HG) and dexamethasone (DEX) on the survival and permeability of trabecular meshwork cells (HTMC), and associated changes in tight junctions. METHODS: Primary cultured... -
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- The effect of ginsenoside Rk1 in junctional protein of severe preeclamptic placenta
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Lim SC, Maeng YS, Kwon JY, Kang MH, Hyang JH, Kim YH, Kwon YK, Park YW
- KMID: 1475007
- Korean J Obstet Gynecol.
- 2009 Mar;52(3):301-308.
OBJECTIVE: To investigate the differential expression of junctional proteins in the normal and preeclamptic human placenta and the effect of ginsenoside Rk1 in junctional proteins. METHODS: Placental tissues from 10 women... -
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- Changes of Tight Junction and Epithelial Cells after Treatment of Cadmium
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Lee SJ, Kim KY, Kim DJ, Chung YH, Kim SS, Lee WB, Cho DY, Sohn DS
- KMID: 1512957
- Korean J Phys Anthropol.
- 2007 Mar;20(1):69-82.
Cadmium (Cd) affects cell proliferation, differentiation, apoptosis and other cellular activities and can cause numerous molecular lesions that would be relevant to carcinogenesis. The mechanism of adverse effects of Cd... -
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- Alpha-tocopherol Prevents H2O2-induced Tight Junction Occludin Disruption in Blood-Brain Barrier
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Lee HS, Namkoong K, Yook KH, Ahn JS, Noh MS, Kim DJ, Chung YH, Kim SS, Lee WB, Kim KY
- KMID: 1583642
- Korean J Phys Anthropol.
- 2006 Sep;19(3):223-233.
Vitamin E is the most important lipid-soluble antioxidant in humans. Although alpha-tocopherol is suggested that it has protective effect from many diseases, little is known about the prevention of occludin alteration... -
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- A Prospective Study of Eosinophilic Esophagitis and the Expression of Tight Junction Proteins in Patients with Gastroesophageal Reflux Disease Symptoms
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Okimoto K, Arai M, Ishigami H, Saito K, Minemura S, Maruoka D, Matsumura , Nakagawa T, Katsuno T, Suzuki M, Nakatani Y, Yokosuka O
- KMID: 2404714
- Gut Liver.
- 2018 Jan;12(1):30-37.
- doi: 10.5009/gnl16600
BACKGROUND/AIMS: Eosinophilic esophagitis (EoE) is often erroneously diagnosed as gastroesophageal reflux disease (GERD). The aim of this study is to investigate the prevalence of EoE and the expression of tight... -
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- Chlorogenic Acid Decreases Retinal Vascular Hyperpermeability in Diabetic Rat Model
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Shin JY, Sohn J, Park KH
- KMID: 1786971
- J Korean Med Sci.
- 2013 Apr;28(4):608-613.
- doi: 10.3346/jkms.2013.28.4.608
To evaluate the effect of chlorogenic acid (CGA), a polyphenol abundant in coffee, on retinal vascular leakage in the rat model of diabetic retinopathy, Sprague-Dawley rats were divided into four... -
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- Effect of Acute Stress on Immune Cell Counts and the Expression of Tight Junction Proteins in the Duodenal Mucosa of Rats
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Lee HS, Kim DK, Kim YB, Lee KJ
- KMID: 2135070
- Gut Liver.
- 2013 Mar;7(2):190-196.
BACKGROUND/AIMS: Duodenal immune alterations have been reported in a subset of patients with functional dyspepsia (FD). The aim of this study was to investigate the effect of acute stress on... -
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- Effect of Triamcinolone on Retinal Vessel-Related Factors in Oxygen-Induced Retinopathy Rats
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Yoo WS, Seo SW, Park JM, Yoo JM, Chung IY
- KMID: 2216403
- J Korean Ophthalmol Soc.
- 2012 Dec;53(12):1864-1869.
- doi: 10.3341/jkos.2012.53.12.1864
PURPOSE: The present study investigated the effects of triamcinolone acetonide (TA) on retinal vessel-related factors and retinal vascular leakage in the retina of oxygen-induced retinopathy (OIR) rats. METHODS: Sprague-Dawley rats used... -
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- Uterine expression of tight junctions in the Canine uterus
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Ahn C, Shin DH, Lee D, Kang HY, Jeung EB
- KMID: 2169092
- J Biomed Res.
- 2015 Sep;16(3):98-103.
- doi: 10.12729/jbr.2015.16.3.098
Tight junctions (TJs) form continuous intercellular contacts in intercellular junctions. TJs involve integral proteins such as occludin (OCLN) and claudins (CLDNs) as well as peripheral proteins such as zona occludens-1... -
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- Effect of Vitamin E Supplementation on Intestinal Barrier Function in Rats Exposed to High Altitude Hypoxia Environment
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Xu C, Sun R, Qiao X, Xu C, Shang X, Niu W, Chao Y
- KMID: 2285525
- Korean J Physiol Pharmacol.
- 2014 Aug;18(4):313-320.
- doi: 10.4196/kjpp.2014.18.4.313
The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induced damage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control),... -
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- Sex and Gender Differences in Gastroesophageal Reflux Disease
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Kim YS, Kim N, Kim GH
- KMID: 2433450
- J Neurogastroenterol Motil.
- 2016 Oct;22(4):575-588.
- doi: 10.5056/jnm16138
It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects... -
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- Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines
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Baek H, Kim KH, Park MY, Kim K, Ko B, Seo HS, Kim BS, Hahn TW, Yi SS
- KMID: 2412562
- J Vet Sci.
- 2017 Aug;18(S1):371-379.
- doi: 10.4142/jvs.2017.18.S1.371
With the increase in international human and material exchanges, contagious and infectious epidemics are occurring. One of the effective methods of epidemic inhibition is the rapid development and supply of... -
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- Comparison of Tight Junction Protein-Related Gene mRNA Expression Levels between Male and Female Gastroesophageal Reflux Disease Patients
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Kim JJ, Kim N, Park JH, Kim YS, Lee SM, Lee DH, Jung HC
- KMID: 2417307
- Gut Liver.
- 2018 Jul;12(4):411-419.
- doi: 10.5009/gnl17419
BACKGROUND/AIMS: Male predominance has been observed in the erosive reflux disease (ERD), but reverse finding in nonerosive reflux disease (NERD). This suggests sex-specific medicine approach is needed but its mechanism... -
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- Blood-Brain Barrier Disruption and Perivascular Beta-Amyloid Accumulation in the Brain of Aged Rats with Spontaneous Hypertension: Evaluation with Dynamic Contrast-Enhanced Magnetic Resonance Imaging
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Wang Y, Zhang R, Tao C, Xu Z, Chen W, Wang C, Song L, Zheng J, Gao F
- KMID: 2410821
- Korean J Radiol.
- 2018 Jun;19(3):498-507.
- doi: 10.3348/kjr.2018.19.3.498
OBJECTIVE: Whether blood-brain barrier (BBB) disruption induced by chronic spontaneous hypertension is associated with beta-amyloid (Aβ) accumulation in the brain remains poorly understood. The purpose of this study was to... -
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- Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
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Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH
- KMID: 2440032
- Exp Mol Med.
- 2018 Feb;50(2):e450.
- doi: 10.1038/emm.2017.282
The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity... -
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- High-fat Diet Accelerates Intestinal Tumorigenesis Through Disrupting Intestinal Cell Membrane Integrity
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Park MY, Kim MY, Seo YR, Kim JS, Sung MK
- KMID: 2353809
- J Cancer Prev.
- 2016 Jun;21(2):95-103.
- doi: 10.15430/JCP.2016.21.2.95
BACKGROUND: Excess energy supply induces chronic low-grade inflammation in association with oxidative stress in various tissues including intestinal epithelium. The objective of this study was to investigate the effect of... -
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