- Role of a 19S Proteasome Subunit- PSMD10(Gankyrin) in Neurogenesis of Human Neural Progenitor Cells
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Sahu I, Nanaware P, Mane M, Mulla SW, Roy S, Venkatraman P
- KMID: 2465887
- Int J Stem Cells.
- 2019 Nov;12(3):463-473.
- doi: 10.15283/ijsc19007
PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function... -
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- A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models
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Heo JR, Hwang KA, Kim SU, Choi KC
- KMID: 2464425
- Cancer Res Treat.
- 2019 Apr;51(2):797-811.
- doi: 10.4143/crt.2018.364
PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into... -
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- Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells
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Ha S, Jeong SH, Yi K, Chu JJ, Kim S, Kim EK, Yu SW
- KMID: 2450215
- Exp Neurobiol.
- 2019 Apr;28(2):229-246.
- doi: 10.5607/en.2019.28.2.229
Neural stem cells (NSCs) have the ability to self-renew and differentiate into neurons, oligodendrocytes, and astrocytes. Highly dynamic nature of NSC differentiation requires the intimate involvement of catabolic processes such... -
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- Molecular Characterization of Primary Human Astrocytes Using Digital Gene Expression Analysis
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Kim JW, Jeong JH
- KMID: 2444199
- Korean J Neurotrauma.
- 2019 Apr;15(1):2-10.
- doi: 10.13004/kjnt.2019.15.e2
OBJECTIVE: Astrocyte dysfunctions are related to several central nervous system (CNS) pathologies. Transcriptomic profiling of human mRNAs to investigate astrocyte functions may provide the basic molecular-biological data pertaining to the... -
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- Alteration of Genomic Imprinting Status of Human Parthenogenetic Induced Pluripotent Stem Cells during Neural Lineage Differentiation
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Lee HJ, Choi NY, Lee SW, Lee Y, Ko K, Kim GJ, Hwang HS, Ko K
- KMID: 2447222
- Int J Stem Cells.
- 2019 Mar;12(1):31-42.
- doi: 10.15283/ijsc18084
BACKGROUND AND OBJECTIVES: Genomic imprinting modulates growth and development in mammals and is associated with genetic disorders. Although uniparental embryonic stem cells have been used to study genomic imprinting, there... -
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- Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury
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Shin JE, Han J, Lim JH, Eun HS, Park KI
- KMID: 2440695
- Neonatal Med.
- 2019 Feb;26(1):1-16.
- doi: 10.5385/nm.2019.26.1.1
Neonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury... -
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- Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking
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Kim SC, Lee EH, Yu JH, Kim SM, Nam BG, Chung HY, Kim YS, Cho SR, Park CH
- KMID: 2432070
- Biomol Ther.
- 2019 Jan;27(1):78-84.
- doi: 10.4062/biomolther.2018.110
Cell therapeutic agents for treating degenerative brain diseases using neural stem cells are actively being developed. However, few systems have been developed to monitor in real time whether the transplanted... -
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- Regulation of Neural Stem Cell Fate by Natural Products
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Kim HJ
- KMID: 2432062
- Biomol Ther.
- 2019 Jan;27(1):15-24.
- doi: 10.4062/biomolther.2018.184
Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent... -
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- The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro
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Moon BS, Ammothumkandy A, Zhang N, Peng L, Ibrayeva A, Bay M, Pratap A, Park HJ, Bonaguidi , Lu W
- KMID: 2439848
- Clin Exp Otorhinolaryngol.
- 2018 Dec;11(4):224-232.
- doi: 10.21053/ceo.2018.00878
OBJECTIVES: Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown.... -
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- Insulin-like Growth Factor-1 Receptor Dictates Beneficial Effects of Treadmill Training by Regulating Survival and Migration of Neural Stem Cell Grafts in the Injured Spinal Cord
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Hwang DH, Park HH, Shin HY, Cui Y, Kim BG
- KMID: 2430107
- Exp Neurobiol.
- 2018 Dec;27(6):489-507.
- doi: 10.5607/en.2018.27.6.489
Survival and migration of transplanted neural stem cells (NSCs) are prerequisites for therapeutic benefits in spinal cord injury. We have shown that survival of NSC grafts declines after transplantation into... -
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- Neural Stem Cell Differentiation Using Microfluidic Device-Generated Growth Factor Gradient
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Kim JH, Sim J, Kim HJ
- KMID: 2420389
- Biomol Ther.
- 2018 Jul;26(4):380-388.
- doi: 10.4062/biomolther.2018.001
Neural stem cells (NSCs) have the ability to self-renew and differentiate into multiple nervous system cell types. During embryonic development, the concentrations of soluble biological molecules have a critical role... -
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- Role of Carbon Monoxide in Neurovascular Repair Processing
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Choi YK
- KMID: 2429047
- Biomol Ther.
- 2018 Mar;26(2):93-100.
- doi: 10.4062/biomolther.2017.144
Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In... -
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- Toll-like receptor 2 promotes neurogenesis from the dentate gyrus after photothrombotic cerebral ischemia in mice
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Seong KJ, Kim HJ, Cai B, Kook MS, Jung JY, Kim WJ
- KMID: 2410104
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):145-153.
- doi: 10.4196/kjpp.2018.22.2.145
The subgranular zone (SGZ) of hippocampal dentate gyrus (HDG) is a primary site of adult neurogenesis. Toll-like receptors (TLRs), are involved in neural system development of Drosophila and innate immune... -
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- Neural Stem Cell Death Mechanisms Induced by Amyloid Beta
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Lee J, Park HH, Koh SH, Choi H
- KMID: 2442729
- Dement Neurocogn Disord.
- 2017 Dec;16(4):121-127.
- doi: 10.12779/dnd.2017.16.4.121
BACKGROUND AND PURPOSE: Amyloid beta (Aβ) is the main component of amyloid plaques, which are deposited in the brains of patients with Alzheimer's disease (AD). Biochemical and animal studies support... -
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- Direct Conversion of Human Umbilical Cord Blood into Induced Neural Stem Cells with SOX2 and HMGA2
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Kim JJ, Shin JH, Yu KR, Lee BC, Kang I, Lee JY, Kim DH, Seo Y, Kim HS, Choi SW, Kang KS
- KMID: 2400876
- Int J Stem Cells.
- 2017 Nov;10(2):227-234.
- doi: 10.15283/ijsc17025
Recent advances have shown the direct reprogramming of mouse and human fibroblasts into induced neural stem cells (iNSCs) without passing through an intermediate pluripotent state. Thus, direct reprogramming strategy possibly... -
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- Candesartan Restores the Amyloid Beta-Inhibited Proliferation of Neural Stem Cells by Activating the Phosphatidylinositol 3-Kinase Pathway
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Choi H, Choi NY, Lee KY, Lee YJ, Koh SH
- KMID: 2442818
- Dement Neurocogn Disord.
- 2017 Sep;16(3):64-71.
- doi: 10.12779/dnd.2017.16.3.64
BACKGROUND AND PURPOSE: Neurogenesis in the adult brain is important for memory and learning, and the alterations in neural stem cells (NSCs) may be an important aspect of Alzheimer's disease... -
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- Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells
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Eghlidospour M, Ghanbari A, Mortazavi , Azari H
- KMID: 2451237
- Anat Cell Biol.
- 2017 Jun;50(2):115-123.
- doi: 10.5115/acb.2017.50.2.115
Due to the importance of neural stem cells (NSCs) in plasticity of the nervous system and treating neurodegenerative diseases, the main goal of this study was to evaluate the effects... -
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- Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor
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Hwang Y, Kim D, Chang D, Ahn B, Kim YB, Kim G
- KMID: 2412580
- J Vet Sci.
- 2017 Jun;18(2):257-260.
- doi: 10.4142/jvs.2017.18.2.257
This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared... -
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- Flow Shear Stress Enhances the Proliferative Potential of Cultured Radial Glial Cells Possibly Via an Activation of Mechanosensitive Calcium Channel
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Park MG, Jang H, Lee SH, Lee CJ
- KMID: 2376574
- Exp Neurobiol.
- 2017 Apr;26(2):71-81.
- doi: 10.5607/en.2017.26.2.71
Radial glial cells (RGCs) which function as neural stem cells are known to be non-excitable and their proliferation depends on the intracellular calcium (Ca²âº) level. It has been well established... -
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- Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node–Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models
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Park GT, Kim SU, Choi KC
- KMID: 2367506
- Cancer Res Treat.
- 2017 Jan;49(1):79-91.
- doi: 10.4143/crt.2015.503
PURPOSE: Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells... -
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