J Stroke.  2016 Sep;18(3):267-272. 10.5853/jos.2016.00206.

Neural Stem Cells and Ischemic Brain

• Zhang Z
• Chopp M

• KMID: 2359503
• DOI: http://doi.org/10.5853/jos.2016.00206

Abstract

Stroke activates neural stem cells in the ventricular-subventricular zone (V/SVZ) of the lateral ventricle, which increases neuroblasts and oligodendrocyte progenitor cells (OPCs). Within the ischemic brain, neural stem cells, neuroblasts and OPCs appear to actively communicate with cerebral endothelial cells and other brain parenchymal cells to mediate ischemic brain repair; however, stroke-induced neurogenesis unlikely plays any significant roles in neuronal replacement. In this mini-review, we will discuss recent findings how intercellular communications between stroke-induced neurogenesis and oligodendrogenesis and brain parenchymal cells could potentially facilitate brain repair processes.

Keyword

Adult neurogenesis; Stroke; Brain repair; Stem cells

MeSH Terms

Brain*
Endothelial Cells
Lateral Ventricles
Neural Stem Cells*
Neurogenesis
Neurons
Oligodendroglia
Stem Cells
Stroke