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Novel glutathione-containing dry-yeast extracts inhibit eosinophilia and mucus overproduction in a murine model of asthma

Kim YH, Choi YJ, Lee EJ, Kang MK, Park SH, Kim DY, Oh H, Park SJ, Kang YH

BACKGROUND/OBSECTIVE: Airway inflammation by eosinophils, neutrophils and alveolar macrophages is a characteristic feature of asthma that leads to pathological subepithelial thickening and remodeling. Our previous study showed that oxidative stress...
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MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease

Yoo KS, Choi HS, Jun DW, Lee HL, Lee OY, Yoon BC, Lee KG, Paik SS, Kim YS, Lee J

BACKGROUND/AIMS: Gallstone pathogenesis is linked to mucin hypersecretion and bacterial infection. Several mucin genes have been identified in gallbladder epithelial cells (GBECs). We investigated MUC expression in cholesterol-associated gallbladder disease...
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TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients

Zhang Y, Wang X, Wang H, Jiao J, Li Y, Fan E, Zhang L, Bachert C

PURPOSE: Chronic rhinosinusitis with nasal polyps (CRSwNP), a mainly Th2 cytokine-mediated disease, often involves mucus secretion. Recent evidence suggests that transmembrane protein 16A (TMEM16A), a calcium-activated Cl- channel (CaCC), can...
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A Melting Method for RNA Extraction from the Mucosal Membrane of the Mouse Middle Ear

Seo YJ, Kim SH, Moon IS, Choi JY

PURPOSE: There is much confusion surrounding the methods of RNA extraction from the middle ear mucosa of mice. In this study, we worked to develop a "melting method," which is...
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Oral Lovastatin Attenuates Airway Inflammation and Mucus Secretion in Ovalbumin-Induced Murine Model of Asthma

Liou CJ, Cheng PY, Huang WC, Chan CC, Chen MC, Kuo ML, Shen JJ

PURPOSE: Lovastatin is an effective inhibitor of cholesterol synthesis. A previous study demonstrated that lovastatin can also suppress airway hyperresponsiveness (AHR) in murine model of asthma. We aimed to investigate...
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A Case of Primary Retroperitoneal Mucinous Cystadenoma Arising from the Retropancreatic Area

Nam YJ, Kim TN, Kim KH, Gu MG, Lee JY

Primary retroperitoneal mucinous cystadenoma is an extremely uncommon tumor, even though mucinous cystadenoma often develops in the ovary and less frequently in the pancreas. A 21-year-old female was admitted to...
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Effect of Prunetin on TNF-alpha-Induced MUC5AC Mucin Gene Expression, Production, Degradation of IkappaB and Translocation of NF-kappaB p65 in Human Airway Epithelial Cells

Ryu J, Lee HJ, Park SH, Sikder MA, Kim JO, Hong JH, Seok JH, Lee CJ

  • KMID: 2320469
  • Tuberc Respir Dis.
  • 2013 Nov;75(5):205-209.
BACKGROUND: We investigated whether prunetin significantly affects tumor necrosis factor-alpha (TNF-alpha)-induced MUC5AC mucin gene expression, production, inhibitory kappa B (IkappaB) degradation and nuclear factor kappa B (NF-kappaB) p65 translocation in...
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An Inverse Relationship between the Expression of the Gastric Tumor Suppressor RUNX3 and Infection with Helicobacter pylori in Gastric Epithelial Dysplasia

Chung WC, Jung SH, Joo KR, Kim MJ, Youn GJ, Kim Y, Lee JS, Lee H, Jung JH, Lee YK

  • KMID: 1712329
  • Gut Liver.
  • 2013 Nov;7(6):688-695.
BACKGROUND/AIMS: This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions. METHODS: We examined 107 patients with gastric epithelial dysplasia who had...
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Cholesterol Depletion in Cell Membranes of Human Airway Epithelial Cells Suppresses MUC5AC Gene Expression

Song KJ, Kim NH, Lee GB, Kim JH, Kwon JH, Kim KS

PURPOSE: If cholesterol in the cell membrane is depleted by treating cells with methyl-beta-cyclodextrin (MbetaCD), the activities of transmembrane receptors are altered in a cell-specific and/or receptor-specific manner. The proinflammatory...
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Berberine Suppresses Interleukin-1beta-Induced MUC5AC Gene Expression in Human Airway Epithelial Cells

Kim KR, Kim NH, Park Y, Kim JH, Lee EJ, Kim KS

  • KMID: 2297593
  • J Rhinol.
  • 2011 Nov;18(2):116-121.
OBJECTIVES: The aim of this study was to investigate whether berberine suppresses interleukin (IL)-1beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, to determine which mitogen-activated protein...
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Effects of Scutellarin on MUC5AC Mucin Production Induced by Human Neutrophil Elastase or Interleukin 13 on Airway Epithelial Cells

Jiang DP, Perelman J, Kolosov VP, Zhou XD

Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial...
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Effects of Curcumin and Genistein on Phorbol Ester or Tumor Necrosis Factor-alpha-Induced Mucin Production from Human Airway Epithelial Cells

Lee SY, Lee HJ, Lee JW, Jeon BK, Kim JO, Lee CJ

BACKGROUND: We investigated whether curcumin and genistein affect the MUC5AC mucin production from human airway epithelial cells that is induced by phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-alpha (TNF-alpha). METHODS:...
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Regulation of Tumor Necrosis Factor-alpha-induced Airway Mucin Production and Gene Expression by Carbenoxolone, Prunetin, and Silibinin

Lee HJ, Lee SY, Jeon BK, Lee JW, Lee MN, Kim JO, Lee CJ

  • KMID: 2319442
  • Tuberc Respir Dis.
  • 2010 Nov;69(5):348-353.
BACKGROUND: In this study, we tried to investigate whether carbenoxolone, prunetin, and silibinin affect tumor necrosis factor (TNF)-alpha-induced MUC5AC mucin production and gene expression from human airway epithelial cells. METHODS: Confluent...
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Expression of MUC3, MUC5AC, MUC6 and Epidermal Growth Factor Receptor in Gallbladder Epithelium according to Gallstone Composition

Kim HJ, Kim JS, Kim KO, Park KH, Yim HJ, Kim JY, Yeon JE, Park JJ, Shim JJ, Byun KS, Bak YT, Lee CH

  • KMID: 772564
  • Korean J Gastroenterol.
  • 2003 Oct;42(4):330-336.
BACKGROUND/AIMS: Gallbladder (GB) mucin is one of the key factors in the gallstone formation. However, there is little information about the diversity of mucin secretion according to the stone composition....
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