- Letter to the Editor: Detection of EML4-ALK and Other ALK Fusion Genes in Lung Cancer: A Lesson from the Leukemia Fusion Gene Analysis and Future Application
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Park TS, Jeon YL, Lee HJ, Jeong JH, Kim SY, Cho EH, Marschalek R, Meyer C
- KMID: 1372806
- J Korean Med Sci.
- 2012 May;27(5):576-577.
- doi: 10.3346/jkms.2012.27.5.576
No abstract available. -
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- F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patients
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Jung YY, Ha HI, Jung SH, Lee MG, Lee HW, Yoon JH, Choi JW, Yeh BI
- KMID: 755114
- Exp Mol Med.
- 2001 Mar;33(1):29-31.
Mutations of the transmembrane conductance regulator (CFTR) gene in cystic fibrosis lead to dysfunction of the lung, pancreas, and sweat glands, etc. To investigate the possibility of the relationship between... -
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- MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2
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Cheng Z, Ma R, Tan W, Zhang L
- KMID: 2155377
- Exp Mol Med.
- 2014 Sep;46(9):e112.
- doi: 10.1038/emm.2014.51
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed... -
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- Flow cytometric analysis of DNA ploidy in primary non-small cell carcinoma of the lung in Korea
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Cheon SH, Sohn HY, Chang J, Kim SK, Ko EH, Kim SK, Lee WY, Lee DY, Shin DH, Jeong ET, Chung HT
- KMID: 1758501
- Yonsei Med J.
- 1993 Dec;34(4):365-370.
- doi: 10.3349/ymj.1993.34.4.365
Flow cytometrically determined nuclear DNA content has been measured on 74 formalin-fixed, paraffin embedded specimens of non-small cell carcinoma of the lung. Of the 60 tumors that were successfully analyzed,... -
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- Clinical Significance of Aberrant Wnt7a Promoter Methylation in Human Non-Small Cell Lung Cancer in Koreans
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Kim TH, Moon JY, Kim SH, Paik SS, Yoon HJ, Shin DH, Park SS, Sohn JW
- KMID: 2129645
- J Korean Med Sci.
- 2015 Feb;30(2):155-161.
- doi: 10.3346/jkms.2015.30.2.155
The Wnt signaling pathway has regulatory roles in cell proliferation, differentiation, and polarity. Aberrant Wnt pathway regulation can lead to abnormal cell proliferation and cancer, and loss of Wnt7a expression... -
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- Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential
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Warth A, Herpel E, Krysa S, Hoffmann H, Schnabel P, Schirmacher P, Mechtersheimer G, Blaker H
- KMID: 1123809
- Exp Mol Med.
- 2009 May;41(5):349-353.
- doi: 10.3858/emm.2009.41.5.039
Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of carcinoids, in... -
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- EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung
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Jang TW, Oak CH, Chang HK, Suo SJ, Jung MH
- KMID: 1785642
- Korean J Intern Med.
- 2009 Mar;24(1):48-54.
- doi: 10.3904/kjim.2009.24.1.48
BACKGROUND/AIMS: Mutations of the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) are important in the pathogenesis of lung cancer, and recent reports have revealed... -
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- LIN28B confers radio-resistance through the posttranscriptional control of KRAS
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Jeong SH, Wu HG, Park WY
- KMID: 1099867
- Exp Mol Med.
- 2009 Dec;41(12):912-918.
- doi: 10.3858/emm.2009.41.12.097
To screen the differentially expressed microRNAs related to radio-resistance, we compared the microRNA profiles of lung cancer cells with different responses to ionizing radiation (IR). Of 328 microRNAs in microarray,... -
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- Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population
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Yoo SS, Hong MJ, Choi JE, Lee JH, Baek SA, Lee WK, Lee SY, Lee SY, Lee J, Cha SI, Kim CH, Cho S, Park JY
- KMID: 2363510
- J Korean Med Sci.
- 2016 Mar;31(3):463-466.
- doi: 10.3346/jkms.2016.31.3.463
Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted... -
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- Hypermethylation of p16(INK4a) in Korean Non-small Cell Lung Cancer Patients
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Hong YS, Roh MS, Kim NY, Lee HJ, Kim HK, Lee KE, Kwak JY, Kim JY
- KMID: 1785786
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S32-S37.
- doi: 10.3346/jkms.2007.22.S.S32
Promoter hypermethylation of the p16(INK4a) gene was investigated in 81 sets of samples of tumor tissue and adjacent normal tissue from Korean patients with primary lung cancer, using the modified... -
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- Concomitance of P-gp/LRP Expression with EGFR Mutations in Exons 19 and 21 in Non-Small Cell Lung Cancers
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Wei H, Lu W, Li M, Zhang Q, Lu S
- KMID: 2466351
- Yonsei Med J.
- 2016 Jan;57(1):50-57.
- doi: 10.3349/ymj.2016.57.1.50
PURPOSE: Traditional chemotherapy is the main adjuvant therapy for the treatment of non-small cell lung cancer (NSCLC). However, the emergence of multi-drug resistance (MDR) has greatly restricted the curative effect... -
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- Comparative Quantification of Plasma hnRNP B1 mRNA in Non-small Cell Lung Cancer Patients by Real-time PCR
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Kim JM, Hwang SH, Song EJ, Lee SY, Kim YD, Lee CH, Lee MK, Chang CL, Lee EY
- KMID: 1096978
- Korean J Lab Med.
- 2009 Jun;29(3):249-255.
- doi: 10.3343/kjlm.2009.29.3.249
BACKGROUND: Circulating cell-free nucleic acids are known to be a noninvasive diagnostic tool for cancer detection. Heterogeneous nuclear ribonucleoprotein (hnRNP) B1, a nuclear core complex, is overexpressed in early stage... -
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- Detection of Plasma BRAF(V600E) Mutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas
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Kim BH, Kim IJ, Lee BJ, Lee JC, Kim IS, Kim SJ, Kim WJ, Jeon YK, Kim SS, Kim YK
- KMID: 2450335
- Yonsei Med J.
- 2015 May;56(3):634-640.
- doi: 10.3349/ymj.2015.56.3.634
PURPOSE: The BRAF(V600E) mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of... -
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- Epidermal Growth Factor Receptor Mutations and the Clinical Outcome in Male Smokers with Squamous Cell Carcinoma of Lung
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Park SH, Ha SY, Lee JI, Lee H, Sim H, Kim YS, Hong J, Park J, Cho EK, Shin DB, Lee JH
- KMID: 1779162
- J Korean Med Sci.
- 2009 Jun;24(3):448-452.
- doi: 10.3346/jkms.2009.24.3.448
Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been reported to be related to certain clinical characteristics (i.e., female, non-smokers with adenocarcinoma) and gefitinib responsiveness.... -
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- Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis
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Song JU, Lee J
- KMID: 2418783
- Yonsei Med J.
- 2018 Mar;59(2):211-218.
- doi: 10.3349/ymj.2018.59.2.211
PURPOSE: Molecular testing in non-small cell lung cancer (NSCLC) aids in identifying oncogenic alterations. The aim of this study was to compare the rates of detection of oncogenic alterations and... -
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- Identification of Tumor Suppressor Loci on the Long Arm of Chromosome 4 in Primary Small Cell Lung Cancers
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Cho ES, Chang J, Chung KY, Shin DH, Kim YS, Kim SK, Kim SK
- KMID: 1118962
- Yonsei Med J.
- 2002 Apr;43(2):145-151.
- doi: 10.3349/ymj.2002.43.2.145
Recent cytogenetic studies have indicated that loss of the long arm of chromosome 4 is a frequent event in small cell lung cancer (SCLC), which suggests the presence of tumor... -
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- Association Between MicroRNA196a2 rs11614913 Genotypes and the Risk of Non-Small Cell Lung Cancer in Korean Population
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Hong YS, Kang HJ, Kwak JY, Park BL, You CH, Kim YM, Kim H
- KMID: 1093272
- J Prev Med Public Health.
- 2011 May;44(3):125-130.
- doi: 10.3961/jpmph.2011.44.3.125
OBJECTIVES: The microRNA (miRNA) miR-196a2 may play an important role in lung cancer development and survival by altering binding activity of target mRNA. In this study, we evaluated their associations... -
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- Identification of Tumor Suppressor Loci on the Long Arm of Chromosome 15 in Primary Small Cell Lung Cancer
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Kee HJ, Shin JH, Chang J, Chung KY, Shin DH, Kim YS, Kim SK, Kim SK
- KMID: 1719071
- Yonsei Med J.
- 2003 Feb;44(1):65-74.
- doi: 10.3349/ymj.2003.44.1.65
Small cell lung cancer (SCLC) frequently shows a loss of heterozygosity (LOH) on chromosome 15q. In order to define the commonly affected region on chromosome 15q, we tested 23 primary... -
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- Genome-Wide Association Study of Lung Cancer in Korean Non-Smoking Women
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Kim JH, Park K, Yim SH, Choi JE, Sung JS, Park JY, Choi YY, Jeon HS, Park JY, Yoon HK, Kim YH, Yoo BS, Kim YT, Hu HJ, Chung YJ, Kim H, Sung SW, Hong YC
- KMID: 2158030
- J Korean Med Sci.
- 2013 Jun;28(6):840-847.
- doi: 10.3346/jkms.2013.28.6.840
Lung cancer in never-smokers ranks as the seventh most common cause of cancer death worldwide, and the incidence of lung cancer in non-smoking Korean women appears to be steadily increasing.... -
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- A Modified Extraction Method of Circulating Free DNA for Epidermal Growth Factor Receptor Mutation Analysis
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Yuan H, Zhu ZZ, Lu Y, Liu F, Zhang W, Huang G, Zhu G, Jiang B
- KMID: 1779697
- Yonsei Med J.
- 2012 Jan;53(1):132-137.
- doi: 10.3349/ymj.2012.53.1.132
PURPOSE: Circulating free DNA (cfDNA) in plasma is promising to be a surrogate for tumor tissue DNA. However, not all epidermal growth factor receptor (EGFR) mutations in tumor tissue DNA... -
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