Exp Mol Med.  2014 Sep;46(9):e112. 10.1038/emm.2014.51.

MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2

• Cheng Z
• Ma R
• Tan W
• Zhang L

• KMID: 2155377
• DOI: http://doi.org/10.1038/emm.2014.51

Abstract

MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.

MeSH Terms

Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/pathology
Cell Movement
Cell Proliferation
Female
Fibroblast Growth Factor 2/*genetics
*Gene Expression Regulation, Neoplastic
Humans
Lung/metabolism/*pathology
Lung Neoplasms/*genetics/metabolism/pathology
Male
MicroRNAs/*genetics
Middle Aged
Neoplasm Invasiveness/genetics/pathology
MicroRNAs
Fibroblast Growth Factor 2