- Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas
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Choi B, Suh Y, Kim WH, Christa L, Park J, Bae CD
- KMID: 1091074
- Exp Mol Med.
- 2007 Dec;39(6):796-804.
Gastric carcinoma is considered to be one of the most prevalent cancers worldwide. We have performed differential-display polymerase chain reaction (DD-PCR) in order to compare the gene expression profile of... -
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- What Is the Significance of Long Non-coding RNA HOX Transcript Antisense Intergenic RNA in Gastric Cancer?
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Lee SK
- KMID: 1730923
- Korean J Gastroenterol.
- 2014 Feb;63(2):137-139.
- doi: 10.4166/kjg.2014.63.2.137
No abstract available. -
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- Gene Expression Profiling of Hepatocellular Carcinoma Derived Cancer Stem Like Cell under Hypoxia
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Choi SH, Lee SW, Ok M, Kim KS, Kim S, Ahn SH
- KMID: 2418927
- Yonsei Med J.
- 2017 Sep;58(5):925-933.
- doi: 10.3349/ymj.2017.58.5.925
PURPOSE: Cancer stem like cells (CSCs), with unlimited self-renewal potential and other stem cell characteristics, occur in several cancers including hepatocellular carcinoma (HCC). Although CSCs can initiate tumors, malignant proliferation,... -
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- Identification of Up-Regulated Genes in Malignant Glioma with Subtraction Hybridization: Preliminary Screening Studies
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Cho YJ
- KMID: 1084505
- Yonsei Med J.
- 2008 Apr;49(2):301-310.
- doi: 10.3349/ymj.2008.49.2.301
PURPOSE: This investigation is intended to obtain differentially expressed genes related to human malignant glioma using Subtractive hybridization. MATERIALS AND METHODS: Subtractive hybridization is potentially faster methods for identifying differentially... -
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- Enhanced expression of the c-myc protooncogene in human intracranial meningiomas
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Kim JH, Lee SH, Cho KJ, Jang JJ, Hong SI, Lee JO
- KMID: 1421954
- J Korean Med Sci.
- 1993 Feb;8(1):68-72.
- doi: 10.3346/jkms.1993.8.1.68
We examined the alteration and expression of c-myc protooncogene in 11 human intracranial meningiomas using Southern blot, Northern blot and immunohistochemical techniques. Southern blot showed neither amplification nor rearrangement but... -
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- Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells
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Kwon D, Choi IH
- KMID: 1779506
- Yonsei Med J.
- 2006 Aug;47(4):551-557.
- doi: 10.3349/ymj.2006.47.4.551
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing... -
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- Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma
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Chen J, Qian Z, Li F, Li J, Lu Y
- KMID: 2412162
- Gut Liver.
- 2017 Jan;11(1):112-120.
- doi: 10.5009/gnl16063
BACKGROUND/AIMS: The integration of multiple profiling data and the construction of a transcriptional regulatory network may provide additional insights into the molecular mechanisms of hepatocellular carcinoma (HCC). The present study... -
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- Expression of the RERG Gene is Gender-Dependent in Hepatocellular Carcinoma and Regulated by Histone Deacetyltransferases
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Wang AG, Fang W, Han YH, Cho SM, Choi JY, Lee KH, Kim WH, Kim JM, Park MG, Yu DY, Kim NS, Lee DS
- KMID: 1781911
- J Korean Med Sci.
- 2006 Oct;21(5):891-896.
- doi: 10.3346/jkms.2006.21.5.891
Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In... -
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- Knockdown of Long Non-Coding RNA NEAT1 Inhibits Proliferation and Invasion and Induces Apoptosis of Osteosarcoma by Inhibiting miR-194 Expression
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Wang H, Yu Y, Fan S, Luo L
- KMID: 2418890
- Yonsei Med J.
- 2017 Nov;58(6):1092-1100.
- doi: 10.3349/ymj.2017.58.6.1092
PURPOSE: Long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) has been implicated as an oncogene in the development and progression of osteosarcoma. This study aims to explore the... -
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- B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1
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Choi YW, Kim HJ, Kim YH, Park SH, Chwae YJ, Lee J, Soh EY, Kim JH, Park TJ
- KMID: 2155385
- Exp Mol Med.
- 2014 Nov;46(11):e120.
- doi: 10.1038/emm.2014.68
B-RafV600E mutant is found in 40-70% of papillary thyroid carcinoma (PTC) and has an important role in the pathogenesis of PTC. The sodium iodide symporter (NIS) is an integral plasma... -
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- miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1
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Arora H, Qureshi R, Jin S, Park AK, Park WY
- KMID: 1009969
- Exp Mol Med.
- 2011 May;43(5):298-304.
- doi: 10.3858/emm.2011.43.5.031
The activation of nuclear factor-kappa B1 (NFkappaB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for... -
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- Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice
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Han JH, Park JH, Kim BY, Chang SN, Kim TH, Park JH, Kim DJ
- KMID: 2344300
- J Vet Sci.
- 2015 Sep;16(3):281-287.
- doi: 10.4142/jvs.2015.16.3.281
Chronic inflammation has been considered an important risk factor for development of prostate cancer. Toll-like receptors (TLRs) recognize microbial moieties or endogenous molecules and play an important role in the... -
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- Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
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Yim JH, Yoon JH, Kim SA, Kim WG, Jeon MJ, Han JM, Sung TY, Kim TY, Kim WB, Hong SJ, Shong YK, Gong G
- KMID: 1779393
- J Korean Med Sci.
- 2011 Sep;26(9):1191-1195.
- doi: 10.3346/jkms.2011.26.9.1191
X-linked inhibitor of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the... -
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- Overexpression of Mucin 13 due to Promoter Methylation Promotes Aggressive Behavior in Ovarian Cancer Cells
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Sung HY, Park AK, Ju W, Ahn JH
- KMID: 1799482
- Yonsei Med J.
- 2014 Sep;55(5):1206-1213.
- doi: 10.3349/ymj.2014.55.5.1206
PURPOSE: Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are... -
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- Impact of Caveolin-1 Expression on the Prognosis of Transitional Cell Carcinoma of the Upper Urinary Tract
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Cho DS, Yim H, Cho KS, Hong SJ, Cho NH, Kim SI, Ahn HS, Kim SJ
- KMID: 1713464
- J Korean Med Sci.
- 2008 Apr;23(2):296-301.
- doi: 10.3346/jkms.2008.23.2.296
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT... -
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- Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse
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Jahng JW, Choi SH, Cha MJ, Kim NY, Hwang SJ, Lee JH
- KMID: 1033103
- Exp Mol Med.
- 2005 Feb;37(1):65-69.
This study was conducted to determine if an oral squamous cell carcinoma alters mRNA expression of serotonin transporter (5-HTT) in the central nervous system. KB cell line derived from a... -
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- LIN28B confers radio-resistance through the posttranscriptional control of KRAS
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Jeong SH, Wu HG, Park WY
- KMID: 1099867
- Exp Mol Med.
- 2009 Dec;41(12):912-918.
- doi: 10.3858/emm.2009.41.12.097
To screen the differentially expressed microRNAs related to radio-resistance, we compared the microRNA profiles of lung cancer cells with different responses to ionizing radiation (IR). Of 328 microRNAs in microarray,... -
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- Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells
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Park HY, Jeon YK, Shin HJ, Kim IJ, Kang HC, Jeong SJ, Chung DH, Lee CW
- KMID: 1094660
- Exp Mol Med.
- 2007 Apr;39(2):195-204.
The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation of chromosome-spindle attachment to mitotic-checkpoint signaling. Thus, disruption of BubR1 activity results in a loss of... -
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- Identification of Differentially Expressed Genes in Papillary Thyroid Cancers
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Lee KY, Huang SM, Li S, Kim JM
- KMID: 1782969
- Yonsei Med J.
- 2009 Feb;50(1):60-67.
- doi: 10.3349/ymj.2009.50.1.60
PURPOSE: Techniques designed to identify differentially expressed genes (DEGs) in tumors have become important in modern pathology. Genefishing technique(TM) using the annealing control primer (ACP) system has recently been developed... -
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- Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells
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He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J
- KMID: 1402316
- Exp Mol Med.
- 2012 Dec;44(12):723-732.
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.... -
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