- Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis
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Kim HS, Shen Q, Nam SW
- KMID: 2344168
- J Korean Med Sci.
- 2015 Oct;30(10):1375-1380.
- doi: 10.3346/jkms.2015.30.10.1375
A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of... -
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- Aberrantly expressed microRNAs in the context of bladder tumorigenesis
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Lee JY, Ryu DS, Kim WJ, Kim SJ
- KMID: 2426517
- Investig Clin Urol.
- 2016 Jun;57(Suppl 1):S52-S59.
- doi: 10.4111/icu.2016.57.S1.S52
MicroRNAs (miRNAs), small noncoding RNAs 19-22 nucleotides in length, play a major role in negative regulation of gene expression at the posttranscriptional level. Several miRNAs act as tumor suppressors or... -
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- MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2
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Cheng Z, Ma R, Tan W, Zhang L
- KMID: 2155377
- Exp Mol Med.
- 2014 Sep;46(9):e112.
- doi: 10.1038/emm.2014.51
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed... -
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- LIN28B confers radio-resistance through the posttranscriptional control of KRAS
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Jeong SH, Wu HG, Park WY
- KMID: 1099867
- Exp Mol Med.
- 2009 Dec;41(12):912-918.
- doi: 10.3858/emm.2009.41.12.097
To screen the differentially expressed microRNAs related to radio-resistance, we compared the microRNA profiles of lung cancer cells with different responses to ionizing radiation (IR). Of 328 microRNAs in microarray,... -
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- MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma
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Zhu H, Luo H, Zuo X
- KMID: 2154260
- Exp Mol Med.
- 2013 Sep;45(9):e41.
miRNAs are important post-transcriptional regulators. The aberrant expression of miRNAs is strongly associated with the initiation and progression of pathophysiologic processes in a wide range of human diseases. Scleroderma (systemic... -
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- miR-526b targets 3' UTR of MMP1 mRNA
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Kim KH, Jung JY, Son ED, Shin DW, Noh M, Lee TR
- KMID: 2155432
- Exp Mol Med.
- 2015 Aug;47(8):e178.
- doi: 10.1038/emm.2015.52
Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of MMP1... -
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- miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
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Makki MS, Haqqi TM
- KMID: 2160620
- Exp Mol Med.
- 2015 Oct;47(10):e189.
- doi: 10.1038/emm.2015.66
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of... -
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- Knockdown of Long Non-Coding RNA NEAT1 Inhibits Proliferation and Invasion and Induces Apoptosis of Osteosarcoma by Inhibiting miR-194 Expression
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Wang H, Yu Y, Fan S, Luo L
- KMID: 2418890
- Yonsei Med J.
- 2017 Nov;58(6):1092-1100.
- doi: 10.3349/ymj.2017.58.6.1092
PURPOSE: Long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) has been implicated as an oncogene in the development and progression of osteosarcoma. This study aims to explore the... -
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- Association of Polymorphism in MicroRNA 604 with Susceptibility to Persistent Hepatitis B Virus Infection and Development of Hepatocellular Carcinoma
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Cheong JY, Shin HD, Cho SW, Kim YJ
- KMID: 2069934
- J Korean Med Sci.
- 2014 Nov;29(11):1523-1527.
- doi: 10.3346/jkms.2014.29.11.1523
MicroRNA polymorphisms may be associated with carcinogenesis or immunopathogenesis of infection. We evaluated whether the mircoRNA-604 (miR-604) polymorphism can affect the persistence of hepatitis B virus (HBV) infection, and the... -
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- MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort
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Han H, Qu G, Han C, Wang Y, Sun T, Li F, Wang J, Luo S
- KMID: 2155403
- Exp Mol Med.
- 2015 Feb;47(2):e138.
- doi: 10.1038/emm.2014.81
The aim of this study was to investigate the expression of circulating microRNAs (miRNAs) in apolipoprotein E (apoE) knockout mice (apoE-/-) and to validate the role of these miRNAs in... -
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- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
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Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
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- miR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6
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Li F, Li XJ, Qiao L, Shi F, Liu W, Li Y, Dang YP, Gu WJ, Wang XG, Liu W
- KMID: 2155381
- Exp Mol Med.
- 2014 Oct;46(10):e116.
- doi: 10.1038/emm.2014.63
Dysregulated microRNA (miRNA) expression has a critical role in tumor development and metastasis. However, the mechanism by which miRNAs control melanoma metastasis is unknown. Here, we report reduced miR-98 expression... -
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- Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression
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Li G, Liu K, Du X
- KMID: 2418785
- Yonsei Med J.
- 2018 Mar;59(2):226-235.
- doi: 10.3349/ymj.2018.59.2.226
PURPOSE: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles... -
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- Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension
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Kim JD, Lee A, Choi J, Park Y, Kang H, Chang W, Lee MS, Kim J
- KMID: 2155429
- Exp Mol Med.
- 2015 Jul;47(7):e175.
- doi: 10.1038/emm.2015.45
Pulmonary arterial hypertension (PAH) is a rare but progressive and currently incurable disease, which is characterized by vascular remodeling in association with muscularization of the arterioles, medial thickening and plexiform... -
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- Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform
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Han H, Wang YH, Qu GJ, Sun TT, Li FQ, Jiang W, Luo SS
- KMID: 2154232
- Exp Mol Med.
- 2013 Mar;45(3):e13.
The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary... -
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- Overexpression of miR-191 Predicts Poor Prognosis and Promotes Proliferation and Invasion in Esophageal Squamous Cell Carcinoma
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Gao X, Xie Z, Wang Z, Cheng K, Liang K, Song Z
- KMID: 2418891
- Yonsei Med J.
- 2017 Nov;58(6):1101-1110.
- doi: 10.3349/ymj.2017.58.6.1101
PURPOSE: Accumulating evidence has shown that dysregulation of microRNA-191 (miR-191) is closely associated with tumorigenesis and progression in a wide range of cancers. This study aimed to explore the potential... -
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- DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells
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Zhou D, Wan Y, Xie D, Wang Y, Wei J, Yan Q, Lu P, Mo L, Xie J, Yang S, Qi X
- KMID: 2155436
- Exp Mol Med.
- 2015 Sep;47(9):e182.
- doi: 10.1038/emm.2015.57
Although methyltransferase has been recognized as a major element that governs the epigenetic regulation of the genome during temozolomide (TMZ) chemotherapy in glioblastoma multiforme (GBM) patients, its regulatory effect on... -
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- Establishment of a canine mammary gland tumor cell line and characterization of its miRNA expression
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Osaki T, Sunden Y, Sugiyama A, Azuma K, Murahata Y, Tsuka T, Ito N, Imagawa T, Okamoto Y
- KMID: 2413139
- J Vet Sci.
- 2016 Sep;17(3):385-390.
- doi: 10.4142/jvs.2016.17.3.385
Canine mammary gland tumors (CMGTs), which are the most common neoplasms in sexually intact female dogs, have been suggested as a model for studying human breast cancer because of several... -
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- MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis
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Pathak S, Grillo AR, Scarpa M, Brun P, D'Inca R, Nai L, Banerjee A, Cavallo D, Barzon L, Palu G, Sturniolo , Buda A, Castagliuolo I
- KMID: 2155656
- Exp Mol Med.
- 2015 May;47(5):e164.
- doi: 10.1038/emm.2015.21
Abnormal levels of microRNA (miR)-155, which regulate inflammation and immune responses, have been demonstrated in the colonic mucosa of patients with inflammatory bowel diseases (IBD), although its role in disease... -
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- Association Between MicroRNA196a2 rs11614913 Genotypes and the Risk of Non-Small Cell Lung Cancer in Korean Population
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Hong YS, Kang HJ, Kwak JY, Park BL, You CH, Kim YM, Kim H
- KMID: 1093272
- J Prev Med Public Health.
- 2011 May;44(3):125-130.
- doi: 10.3961/jpmph.2011.44.3.125
OBJECTIVES: The microRNA (miRNA) miR-196a2 may play an important role in lung cancer development and survival by altering binding activity of target mRNA. In this study, we evaluated their associations... -
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