J Prev Med Public Health.  2011 May;44(3):125-130. 10.3961/jpmph.2011.44.3.125.

Association Between MicroRNA196a2 rs11614913 Genotypes and the Risk of Non-Small Cell Lung Cancer in Korean Population

• Hong YS
• Kang HJ
• Kwak JY
• Park BL
• You CH
• Kim YM
• Kim H

• KMID: 1093272
• DOI: http://doi.org/10.3961/jpmph.2011.44.3.125

Abstract

OBJECTIVES
The microRNA (miRNA) miR-196a2 may play an important role in lung cancer development and survival by altering binding activity of target mRNA. In this study, we evaluated their associations with the susceptibility of non-small cell lung cancers (NSCLC) by case-control study in a Korean population.
METHODS
We performed genotyping analyses for miR-196a2 rs11614913 T/C at miRNA regions in a case-control study using blood samples of 406 NSCLC patient and 428 cancer-free control groups.
RESULTS
The total C allele frequencies for miR-196a2 were 48.8% for the patients and 45.6% for the controls; and the genotype frequencies of TT, TC, and CC were 23.7%, 55.2%, and 21.1% for the patients and 31.1%, 46.35%, and 22.4% for the controls (p<0.05). Participants who possesses TC/CC genotypes showed high risk for NSCLC compared to those possessed TT genotypes (OR, 1.42; 95% CI, 1.03 to 1.96). The association was persisted in 60 and older age group, male, smokers, those without family history for cancer. However, no significant association of CC genotypes in recessive genetic model was observed.
CONCLUSIONS
In conclusion, this case-control study provides evidence that miR-196a2 rs11614913 C/T polymorphisms are associated with a significantly increased risk of NSCLC in a dominant model, indicating that common genetic polymorphisms in miR-196a2 rs11614913 are associated with NSCLC. The association of miR196a2 rs11614913 polymorphisms and NSCLC risk require confirmation through additional larger studies.

Keyword

MicroRNA; Non-small cell lung cancer; Polymorphism

MeSH Terms

Age Factors
Aged
*Asian Continental Ancestry Group
Carcinoma, Non-Small-Cell Lung/*genetics
Case-Control Studies
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms/*genetics
Male
MicroRNAs/*genetics
Middle Aged
Polymorphism, Genetic
Republic of Korea
Risk Factors
Sex Factors
Smoking/ethnology