- Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations
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Sim JK, Choi J, Lee SY
- KMID: 2547637
- Korean J Intern Med.
- 2023 Nov;38(6):787-796.
- doi: 10.3904/kjim.2023.345
Lung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell... -
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- Antimetastatic effect of fucoidan against non-small cell lung cancer by suppressing non-receptor tyrosine kinase and extracellular signalrelated kinase pathway
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Muneerungsee N, Tanasawet S, Sukketsiri W
- KMID: 2546943
- Nutr Res Pract.
- 2023 Oct;17(5):844-854.
- doi: 10.4162/nrp.2023.17.5.844
BACKGROUND/OBJECTIVES: Fucoidan, a polysaccharide content in brown algae, has been reported to inhibit the growth of cancer cells. The present study aimed to investigate the suppression effects of fucoidan on... -
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- Subtype-Based Microbial Analysis in Non-small Cell Lung Cancer
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Jang HJ, Lee E, Cho YJ, Lee SH
- KMID: 2546003
- Tuberc Respir Dis.
- 2023 Oct;86(4):294-303.
- doi: 10.4046/trd.2022.0149
Background: The human lung serves as a niche for a unique and dynamic bacterial community related to the development and aggravation of multiple respiratory diseases. Therefore, identifying the microbiome status... -
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- Exploring the past, present, and future of postoperative radiotherapy for N2 stage non-small cell lung cancer
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Kim BH, Kim JS, Kim HJ
- KMID: 2546207
- Radiat Oncol J.
- 2023 Sep;41(3):144-153.
- doi: 10.3857/roj.2023.00430
Despite conventionally applied postoperative radiotherapy (PORT) in pathological N2 (pN2) stage non-small cell lung cancer (NSCLC) considering high locoregional recurrence, its survival benefit has been a continuous topic of debate.... -
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- Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non–Small Cell Lung Cancer
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Lee SH, Kim EY, Han JM, Han G, Chang YS
- KMID: 2544166
- Cancer Res Treat.
- 2023 Jul;55(3):851-864.
- doi: 10.4143/crt.2022.1527
Purpose The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth and proliferation by growth factor coordination and amino acid availability. Leucyl-tRNA synthetase 1 (LARS1) senses the intracellular leucine... -
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- Diagnostic Performance of Endosonography to Detect Mediastinal Lymph Node Metastasis in Patients with Radiological N1 Non–Small Cell Lung Cancer
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Kim BG, Cho JH, Shin SH, Lee K, Um SW, Kim H, Kim J, Shim YM, Jeong BH
- KMID: 2544164
- Cancer Res Treat.
- 2023 Jul;55(3):832-840.
- doi: 10.4143/crt.2022.1428
Purpose Guidelines recommend that non–small cell lung cancer (NSCLC) patients with suspected hilar lymph node (LN) metastases should undergo invasive mediastinal LN staging prior to surgical treatment via endosonography. We... -
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- Genomic Characteristics and the Potential Clinical Implications in Oligometastatic Non–Small Cell Lung Cancer
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Liao R, Chen K, Li J, He H, Yi G, Huang M, Chen R, Shen L, Zhang X, Xu Z, Yang Z, Peng Y
- KMID: 2544163
- Cancer Res Treat.
- 2023 Jul;55(3):814-831.
- doi: 10.4143/crt.2022.1315
Purpose Oligometastatic non–small cell lung cancer (NSCLC) patients have been increasingly regarded as a distinct group that could benefit from local treatment to achieve a better clinical outcome. However, current... -
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- Picropodophyllotoxin Inhibits Cell Growth and Induces Apoptosis in Gefitinib-Resistant Non-Small Lung Cancer Cells by Dual-Targeting EGFR and MET
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Lee JY, Kang BY, Jung SJ, Kwak AW, Lee SO, Park JW, Joo SH, Yoon G, Lee MH, Shim JH
- KMID: 2539589
- Biomol Ther.
- 2023 Mar;31(2):200-209.
- doi: 10.4062/biomolther.2022.113
Patients with non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) amplification or sensitive muta-tions initially respond to the tyrosine kinase inhibitor gefitinib, however, the treatment becomes less effective... -
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- Real-World Study of Osimertinib in Korean Patients with Epidermal Growth Factor Receptor T790M Mutation–Positive Non–Small Cell Lung Cancer
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Lee JH, Kim EY, Park CK, Lee SY, Lee Mk, Yoon SH, Lee JE, Lee SH, Kim SJ, Lee SY, Lim JH, Jang TW, Jang SH, Lee KY, Lee SH, Yang SH, Park DW, Park CK, Kang HS, Yeo CD, Choi CM, Lee JC
- KMID: 2537997
- Cancer Res Treat.
- 2023 Jan;55(1):112-122.
- doi: 10.4143/crt.2022.381
Purpose Although osimertinib is the standard-of-care treatment of epidermal growth factor receptor (EGFR) T790M mutation–positive non–small cell lung cancer, real-world evidence on the efficacy of osimertinib is not enough to... -
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- Lazertinib: on the Way to Its Throne
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Lee J, Hong MH, Cho BC
- KMID: 2532714
- Yonsei Med J.
- 2022 Sep;63(9):799-805.
- doi: 10.3349/ymj.2022.63.9.799
Lazertinib is an oral, irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that forms an irreversible covalent bond to the Cys797 residue in the ATP-binding site of... -
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- Clinical Efficacy of Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer Patients with Liver Metastases: A Network Meta-Analysis of Nine Randomized Controlled Trials
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Yin Q, Dai L, Sun R, Ke P, Liu L, Jiang B
- KMID: 2531326
- Cancer Res Treat.
- 2022 Jul;54(3):803-816.
- doi: 10.4143/crt.2021.764
Purpose This network meta-analysis (NMA) was conducted to compare the efficacy of immune checkpoint inhibitors in advanced non–small cell lung cancer (NSCLC) patients with liver metastases. Materials and Methods English literature... -
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- Optimal positive lymph node ratio showing the benefit of postoperative radiotherapy in pathologic N2 non-small cell lung cancer: an exploratory study using the Surveillance, Epidemiology, and End Results data
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Lee S, Noh OK
- KMID: 2527627
- Radiat Oncol J.
- 2022 Mar;40(1):37-44.
- doi: 10.3857/roj.2021.00969
Purpose: This study aimed to identify the clinical parameters having the beneficial effect of postoperative radiotherapy (PORT) in pathologic N2 (pN2) non-small cell lung cancer (NSCLC) using the Surveillance, Epidemiology,... -
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- ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model
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Lee JM, Kim HS, Kim A, Chang YS, Lee JG, Cho J, Kim EY
- KMID: 2523329
- Yonsei Med J.
- 2022 Jan;63(1):16-25.
- doi: 10.3349/ymj.2022.63.1.16
Purpose: Tumor radioresistance and dose-limiting toxicity restrict the curative potential of radiotherapy, requiring novel approaches to overcome the limitations and augment the efficacy. Here, we investigated the effects of signal... -
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- Guidelines for the Investigation and Management of Ground Glass Nodules
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Lee JH, Hong JI, Kim HK
- KMID: 2521099
- J Chest Surg.
- 2021 Oct;54(5):333-337.
- doi: 10.5090/jcs.21.021
The clinical significance of ground-glass nodules (GGNs) has been investigated in extensive clinical research for many years. The natural history of GGNs is known to be closely related to their... -
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- Pharmacokinetic properties and bioequivalence of gefitinib 250 mg in healthy Korean male subjects
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Moon SJ, Kim Y, Jeon JY, Park SJ, Kwak YG, Kim MG
- KMID: 2525614
- Transl Clin Pharmacol.
- 2021 Sep;29(3):171-179.
- doi: 10.12793/tcp.2021.29.e17
Gefitinib is an anti-cancer drug used to treat non-small cell lung cancer. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 2 orally administered... -
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- Salvage radiation therapy for postoperative locoregionally recurrent non-small cell lung cancer: a single-center experience
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Jo YY, Kim SS, Song SY, Choi EK
- KMID: 2520457
- Radiat Oncol J.
- 2021 Sep;39(3):210-218.
- doi: 10.3857/roj.2021.00696
Purpose: To determine the effectiveness of salvage radiation therapy (RT) in patients with locoregional recurrence (LRR) following initial curative resection of non-small cell lung cancer (NSCLC) and identify the prognostic... -
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- Robot-Assisted Thoracic Surgery in Non-small Cell Lung Cancer
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Lee JH, Hong JI, Kim HK
- KMID: 2519137
- J Chest Surg.
- 2021 Aug;54(4):266-278.
- doi: 10.5090/jcs.21.070
Lobectomy is the standard treatment for early non-small cell lung cancer. Various surgical techniques for lobectomy have been developed, and minimally invasive thoracic surgery, such as video-assisted thoracic surgery or... -
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- Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer
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Nam CH, Koh J, Ock CY, Kim M, Keam B, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS
- KMID: 2517814
- Korean J Intern Med.
- 2021 Jul;36(4):975-984.
- doi: 10.3904/kjim.2020.178
Background/Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer. Methods:... -
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- Surgical Impacts of Metastatic Nonsmall Cell Lung Cancer to the Thoracic and Lumbar Spine
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Jung Jm, Hyun SJ, Kim KJ
- KMID: 2513074
- J Korean Med Sci.
- 2021 Feb;36(7):e52.
- doi: 10.3346/jkms.2021.36.e52
Background: Surgery for spinal metastasis is rapidly increasing in frequency with procedures ranging from laminectomy to spondylectomy combined with stabilization. This study investigated the effect of various surgical procedures for... -
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- Rapidly Destructive Arthrosis of Knee Following Treatment of Crizotinib in a Patient with Non-Small-Cell Lung Cancer
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Hwang JT, Choi JH, Park CH, Yoon KJ, Lee YT, Do JG
- KMID: 2510189
- Clin Pain.
- 2020 Dec;19(2):120-123.
- doi: 10.35827/cp.2020.19.2.120
Rapidly destructive arthrosis is a rare syndrome characterized by narrowing of the joint space and rapid joint destruction within 6∼12 months. A 62-year-old woman with anaplastic lymphoma kinase rearranged non-small-cell... -
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