J Korean Med Sci.  2015 Oct;30(10):1375-1380. 10.3346/jkms.2015.30.10.1375.

Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis

• Kim HS
• Shen Q
• Nam SW

• KMID: 2344168
• DOI: http://doi.org/10.3346/jkms.2015.30.10.1375

Abstract

A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of gene expression that promote formation of heterochromatin by deacetylating histone and non-histone proteins. Aberrant regulation of HDACs contributes to malignant transformation and progression in a wide variety of human cancers, including hepatocellular carcinoma (HCC), gastric cancer, lung cancer, and other cancers. Thus, the roles of HDACs have been extensively studied because of their potential as therapeutic targets. However, the underlying mechanism leading to deregulation of individual HDACs remains largely unknown. Some reports have suggested that functional microRNAs (miRNAs) modulate epigenetic effector molecules including HDACs. Here, we describe the oncogenic or tumor suppressive functions of HDAC families and their regulatory miRNAs governing HDAC expression in hepatocarcinogenesis.

Keyword

Histone Deacetylases; MicroRNAs; Carcinoma; Hepatocellular

MeSH Terms

Carcinogenesis/*genetics/pathology
Carcinoma, Hepatocellular/*genetics/pathology
Epigenesis, Genetic/genetics
Gene Expression Regulation, Neoplastic/genetics
Histone Deacetylases/*genetics
Histones/*metabolism
Humans
Liver Neoplasms/*genetics/pathology
MicroRNAs/*genetics
RNA Processing, Post-Transcriptional/genetics
Tumor Suppressor Proteins/genetics
Histones
MicroRNAs
Tumor Suppressor Proteins
Histone Deacetylases

Figure

• 

  Fig. 1 Schematic summary of the regulation of HDACs family and their regulatory miRNAs in liver cancer. HDACs are regulated by growth factors and that in turn induce initiation and progression of liver cancer. On the other hand, miRNAs also modulate HDACs family and closely associated with aberrant expression of HDACs. Therefore, these comprehensive HDACs and miRNAs network may contribute to liver tumorigenesis.

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