- The function of p27(KIP1) during tumor development
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Lee J, Kim SS
- KMID: 1122277
- Exp Mol Med.
- 2009 Nov;41(11):765-771.
- doi: 10.3858/emm.2009.41.11.102
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which... -
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- Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis
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Kim HS, Shen Q, Nam SW
- KMID: 2344168
- J Korean Med Sci.
- 2015 Oct;30(10):1375-1380.
- doi: 10.3346/jkms.2015.30.10.1375
A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of... -
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- p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest
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Chae HD, Kim SY, Park SE, Kim J, Shin DY
- KMID: 1245266
- Exp Mol Med.
- 2012 Mar;44(3):236-240.
- doi: 10.3858/emm.2012.44.3.018
We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin... -
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- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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- Integrative epigenomic and genomic analysis of malignant pheochromocytoma
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Sandgren J, Andersson , Rada-Iglesias A, Enroth S, Akerstrom , Dumanski J, Komorowski J, Westin G, Wadelius C
- KMID: 1104209
- Exp Mol Med.
- 2010 Jul;42(7):484-502.
- doi: 10.3858/emm.2010.42.7.050
Epigenomic and genomic changes affect gene expression and contribute to tumor development. The histone modifications trimethylated histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) are epigenetic regulators associated to... -
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- Comparison of Methylation Profiling in Cancerous and Their Corresponding Normal Tissues from Korean Patients with Breast Cancer
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Jung EJ, Kim IS, Lee EY, Kang JE, Lee SM, Kim DC, Kim JY, Park ST
- KMID: 1711317
- Ann Lab Med.
- 2013 Nov;33(6):431-440.
- doi: 10.3343/alm.2013.33.6.431
BACKGROUND: Aberrant DNA hypermethylation plays a pivotal role in carcinogenesis and disease progression; therefore, accurate measurement of differential gene methylation patterns among many genes is likely to reveal biomarkers for... -
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- DNA Methylation Patterns of Ulcer-Healing Genes Associated with the Normal Gastric Mucosa of Gastric Cancers
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Hong SJ, Oh JH, Jung YC, Kim YH, Kim SJ, Kang SJ, Seo EJ, Choi SW, Kang MI, Rhyu MG
- KMID: 1778036
- J Korean Med Sci.
- 2010 Mar;25(3):405-417.
- doi: 10.3346/jkms.2010.25.3.405
Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy... -
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- Methylation Pattern of DNA Repair Genes and Microsatellite Instability in Hepatocelluar Carcinoma
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Park JH, Cho SB, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Lee JH, Kim SJ
- KMID: 1113480
- Korean J Gastroenterol.
- 2006 Nov;48(5):327-336.
BACKGROUND/AIMS: Epigenetic silencing of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT), hMLH1 and hMSH3, by promoter hypermethylation have been observed in various cancers. However, the relationship between hypermethylation of DNA... -
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- Endothelial progenitor cell transplantation decreases lymphangiogenesis and adverse myocardial remodeling in a mouse model of acute myocardial infarction
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Park JH, Yoon JY, Ko SM, Jin SA, Kim JH, Cho CH, Kim JM, Lee JH, Choi SW, Seong IW, Jeong JO
- KMID: 1022123
- Exp Mol Med.
- 2011 Aug;43(8):479-485.
- doi: 10.3858/emm.2011.43.8.054
Cardiac lymphatic system in the remodeling after acute myocardial infarction (AMI) has been overlooked. We wanted to investigate the role of bone marrow-derived endothelial progenitor cells (EPCs) and their contribution... -
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