- Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker
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Youn HD
- KMID: 2382712
- Exp Mol Med.
- 2017 Apr;49(4):e321.
- doi: 10.1038/emm.2017.38
No abstract available. -
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- Perspectives of International Human Epigenome Consortium
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Bae JB
- KMID: 1806265
- Genomics Inform.
- 2013 Mar;11(1):7-14.
- doi: 10.5808/GI.2013.11.1.7
As the International Human Epigenome Consortium (IHEC) launched officially at the 2010 Washington meeting, a giant step toward the conquest of unexplored regions of the human genome has begun. IHEC... -
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- Writing, erasing and reading histone lysine methylations
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Hyun K, Jeon J, Park K, Kim J
- KMID: 2382715
- Exp Mol Med.
- 2017 Apr;49(4):e324.
- doi: 10.1038/emm.2017.11
Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their... -
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- Hypo-osmotic swelling test as a predictor for nuclear maturity of sperms assessed by aniline blue staining
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Jee BC, Moon SY
- KMID: 2269756
- Korean J Obstet Gynecol.
- 1999 Aug;42(8):1782-1788.
OBJECTIVE: Many cases of fertilization failure after ICSI is attributed to decondensation defect of sperm head, therefore, selection of sperm with well-condensed, fully-matured nucleus is critical for successful fertilization. During... -
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- The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression
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Choi WJ
- KMID: 2170624
- Biomol Ther.
- 2014 Jul;22(4):308-313.
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1... -
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- Immune-mediated Inner Ear Dysfunction Caused by Histones, as Planted Target Antigens
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Park KY, Cho CS, Kim JW, Lee GW, Lee CH, Hozawa K, Takasaka T
- KMID: 1887273
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Jun;45(6):574-578.
BACKGROUND AND OBJECTIVES: Histones, a set of highly cationic proteins essentially involved in the binding and packing of DNA in the cell nucleus chromatin, have five subclasses (H1, H2a, H2b,... -
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- Effect of Histone H1 on Collagen Induced Arthritis in Mice
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Yang JH, Shin KM, Kim DS
- KMID: 2037362
- Korean J Pediatr.
- 2004 Jul;47(7):779-788.
OBJECTIVE: Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule... -
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- RNA polymerase II carboxy-terminal domain with multiple connections
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Cho EJ
- KMID: 1047075
- Exp Mol Med.
- 2007 Jun;39(3):247-254.
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of... -
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- Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective
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Lent H, Lee KE, Park HS
- KMID: 2166531
- Genomics Inform.
- 2015 Dec;13(4):152-155.
- doi: 10.5808/GI.2015.13.4.152
Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different... -
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- The Global Histone Modification Patterns of Osteosarcoma
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Do SI, Lim SJ, Kim YW, Olvi LG, Santini-Araujo E, Park YK
- KMID: 1443747
- Korean J Pathol.
- 2011 Apr;45(2):146-150.
- doi: 10.4132/KoreanJPathol.2011.45.2.146
BACKGROUND: Epigenetic alteration may affect a patient's prognosis by altering the development and progression of the tumor. Some recent reports have identified a correlation between histone modification and patient outcome.... -
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- Msi1-Like (MSIL) Proteins in Fungi
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Yang DH, Maeng S, Bahn YS
- KMID: 2312679
- Mycobiology.
- 2013 Mar;41(1):1-12.
Msi1-like (MSIL) proteins, which are eukaryote-specific and contain a series of WD40 repeats, have pleiotropic roles in chromatin assembly, DNA damage repair, and regulation of nutrient/stress-sensing signaling pathways. In the... -
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- Screening of Peptide Libraries to Investigate the Substrate Specificity of UL97 Protein Kinase from Human Cytomegalovirus
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Baek MC
- KMID: 2055018
- J Bacteriol Virol.
- 2006 Jun;36(2):119-124.
- doi: 10.4167/jbv.2006.36.2.119
Human cytomegalovirus encodes an unusual protein kinase UL97 which can phosphorylate exogenous substrates, including histone H2B and nucleoside analogs such as ganciclovir. The previous result interestingly showed that the peptides... -
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- Epigenetics in Head and Neck Cancer
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Park IS
- KMID: 2277106
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2009 Dec;52(12):943-948.
- doi: 10.3342/kjorl-hns.2009.52.12.943
While genetic alterations in head and neck cancer have long been documented, the appreciation of epigenetic changes is more recent. Epigenetics of head and neck cancer becomes an area of... -
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- Dual Inhibitors Against Topoisomerases and Histone Deacetylases
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Seo YH
- KMID: 2171332
- J Cancer Prev.
- 2015 Jun;20(2):85-91.
- doi: 10.15430/JCP.2015.20.2.85
Topoisomerases and histone deacetylases (HDACs) are considered as important therapeutic targets for a wide range of cancers, due to their association with the initiation, proliferation and survival of cancer cells.... -
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- Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
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Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H
- KMID: 2458551
- Exp Neurobiol.
- 2019 Aug;28(4):537-546.
- doi: 10.5607/en.2019.28.4.537
Silent information regulator 2 (Sirtuin2 / SIRT2) is a NADâº-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins... -
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- Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs
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Lee JH, Cheong HM, Kang MY, Kim SY, Kang Y
- KMID: 1982566
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):343-348.
- doi: 10.4196/kjpp.2009.13.5.343
53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage... -
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- Epigenetic Mechanisms of Early Adverse Experience in the Development of Depression
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Seo MK, Lee JG, Park SW, Lee BJ, Baek JH, Kim YH
- KMID: 2287771
- Korean J Psychopharmacol.
- 2014 Jul;25(3):91-100.
Depression is a common mental illness with a high lifetime prevalence rate in the general population. However, the pathophysiology of depression is still poorly understood. Recent studies showed that environmental... -
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- Histone lysine demethylases in mammalian embryonic development
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Shen H, Xu W, Lan F
- KMID: 2382716
- Exp Mol Med.
- 2017 Apr;49(4):e325.
- doi: 10.1038/emm.2017.57
Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas... -
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- Links between Serine Biosynthesis Pathway and Epigenetics in Cancer Metabolism
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Kim H, Park YJ
- KMID: 2417711
- Clin Nutr Res.
- 2018 Jul;7(3):153-160.
- doi: 10.7762/cnr.2018.7.3.153
Cancer metabolism is considered as one of major cancer hallmarks. It is important to understand cancer-specific metabolic changes and its impact on cancer biology to identify therapeutic potentials. Among cancer-specific... -
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- Modulation of gene expression dynamics by co-transcriptional histone methylations
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Woo H, Ha SD, Lee SB, Buratowski S, Kim T
- KMID: 2382717
- Exp Mol Med.
- 2017 Apr;49(4):e326.
- doi: 10.1038/emm.2017.19
Co-transcriptional methylations of histone H3 at lysines 4 and 36, highly conserved methyl marks from yeast to humans, have profound roles in regulation of histone acetylation. These modifications function to... -
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