- Dual Inhibitors Against Topoisomerases and Histone Deacetylases
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Seo YH
- KMID: 2171332
- J Cancer Prev.
- 2015 Jun;20(2):85-91.
- doi: 10.15430/JCP.2015.20.2.85
Topoisomerases and histone deacetylases (HDACs) are considered as important therapeutic targets for a wide range of cancers, due to their association with the initiation, proliferation and survival of cancer cells.... -
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- HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases
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Yoon S, Eom GH
- KMID: 2152651
- Chonnam Med J.
- 2016 Jan;52(1):1-11.
- doi: 10.4068/cmj.2016.52.1.1
Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated in... -
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- Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis
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Kim HS, Shen Q, Nam SW
- KMID: 2344168
- J Korean Med Sci.
- 2015 Oct;30(10):1375-1380.
- doi: 10.3346/jkms.2015.30.10.1375
A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of... -
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- Epigenetic Modifications: Novel Therapeutic Approach for Thyroid Cancer
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Zhu X, Cheng SY
- KMID: 2389812
- Endocrinol Metab.
- 2017 Sep;32(3):326-331.
- doi: 10.3803/EnM.2017.32.3.326
The incidence of thyroid cancer is growing the fastest among all cancers in the United States, especially in women. The number of patients with thyroid neoplasm is part of an... -
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- Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae
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He Y, Mei H, Yu H, Sun S, Ni W, Li H
- KMID: 2155359
- Exp Mol Med.
- 2014 May;46(5):e94.
- doi: 10.1038/emm.2014.18
Histone deacetylases are involved in many biological processes and have roles in regulating cell behaviors such as cell cycle entry, cell proliferation and apoptosis. However, the effect of histone deacetylases... -
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- Modulation of gene expression dynamics by co-transcriptional histone methylations
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Woo H, Ha SD, Lee SB, Buratowski S, Kim T
- KMID: 2382717
- Exp Mol Med.
- 2017 Apr;49(4):e326.
- doi: 10.1038/emm.2017.19
Co-transcriptional methylations of histone H3 at lysines 4 and 36, highly conserved methyl marks from yeast to humans, have profound roles in regulation of histone acetylation. These modifications function to... -
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- New Aspects of Vascular Calcification: Histone Deacetylases and Beyond
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Kwon DH, Kim YK, Kook H
- KMID: 2390298
- J Korean Med Sci.
- 2017 Nov;32(11):1738-1748.
- doi: 10.3346/jkms.2017.32.11.1738
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases,... -
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- Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A
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Lee JS
- KMID: 1522935
- Cancer Res Treat.
- 2007 Sep;39(3):125-130.
PURPOSE: Ataxia-telangiectasia mutated (ATM) kinase regulates diverse cellular DNA damage responses, including genome surveillance, cell growth, and gene expression. While the role of histone acetylation/deacetylation in gene expression is well... -
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- Effects of Trichostatin A on the Chondrogenesis from Human Mesenchymal Stem Cells
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Lee J, Im GI
- KMID: 2394974
- Tissue Eng Regen Med.
- 2017 Aug;14(4):403-410.
- doi: 10.1007/s13770-017-0041-6
Histone deacetylase inhibitors (HDACi) are a class of compounds that suppress the function of histone deacetylases (HDACs). This study was performed to examine the effects of Trichostatin A (TSA), a... -
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- IL-4 and HDAC Inhibitors Suppress Cyclooxygenase-2 Expression in Human Follicular Dendritic Cells
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Cho W, Hong SH, Choe J
- KMID: 1431929
- Immune Netw.
- 2013 Apr;13(2):75-79.
- doi: 10.4110/in.2013.13.2.75
Evidence for immunoregulatory roles of prostaglandins (PGs) is accumulating. Since our observation of PG production by human follicular dendritic cells (FDCs), we investigated the regulatory mechanism of PG production in... -
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- New Promising Therapeutic Modalities for Thyroid Cancers: Histone Deacetylase Inhibitor, PPAR-gamma Agonist, and Retinoic Acid
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Chung WY, Clark OH
- KMID: 2375954
- Korean J Endocr Surg.
- 2005 Dec;5(2):69-74.
- doi: 10.16956/kjes.2005.5.2.69
Most patients with thyroid cancer have well differentiated tumors that usually respond to conventional therapy including total or near total thyroidectomy, radioiodine ablation and TSH suppression. About 10% of patients,... -
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- Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization
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Kim JH, Moon SH, No M, Kim JJ, Choi EJ, Cho BJ, Kim JS, Kim IH, Kim IA
- KMID: 2344087
- Cancer Res Treat.
- 2016 Jul;48(3):1130-1140.
- doi: 10.4143/crt.2015.206
PURPOSE: Histone deacetylase (HDAC) inhibitors radiosensitize tumor cells. To elucidate mechanisms underlying radiosensitization by HDAC inhibition, understanding of differential contributions of HDAC isotypes is needed. The aim of this study... -
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- Apoptotic Effect of Combination Treatment with a Proteasome Inhibitor, Lactacystin, and a Histone Deacetylase Inhibitor, Trichostatin A, on MCF-7 Cells
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Kim GC, Shin YJ, Kim IR, Lee MH, Hwang YS, Gil YG, Park BS
- KMID: 1510218
- Korean J Anat.
- 2006 Dec;39(6):443-452.
Although much information has been accumulated about the synergistic interaction of proteasome inhibitors and HDAC inhibitors to induce apoptosis in a certain type of cells, much less is known currently... -
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- Pathogenesis and Pathophysiology of Chronic Obstructive Pulmonary Disease (COPD)
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Kim WD
- KMID: 2135206
- Hanyang Med Rev.
- 2005 Nov;25(4):15-21.
With the rise in cigarette smoking, COPD has emerged as a critical health problem and unmet medical need worldwide. Much of the information concerning the pathogenesis of COPD comes from... -
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- The antidepressant action of 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5
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Park MH, Choi M, Kim YS, Son H
- KMID: 2410105
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):155-162.
- doi: 10.4196/kjpp.2018.22.2.155
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we... -
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- Molecular markers associated with radiation resistance and new molecular agents
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Bae DS
- KMID: 2272912
- Korean J Obstet Gynecol.
- 2006 Nov;49(11):2243-2252.
Radiation therapy is a key modality in the management of a majority of patients diagnosed with cancer. To know prognostic markers related radiation response can aid in refining our treatment... -
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- Epigenetic Changes (Aberrant DNA Methylation) in Colorectal Neoplasia
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Kim YS, Deng G
- KMID: 2284042
- Gut Liver.
- 2007 Jun;1(1):1-11.
Both genetic and epigenetic events have been implicated in the stepwise histological progression involving adenoma-carcinoma and hyperplastic polyp/serrated adenoma-carcinoma sequences in the development of colorectal cancer. Genetic changes have been... -
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- Effects of Histone Deacetylase Inhibitor (Valproic Acid) on the Expression of Hypoxia-inducible Factor-1 Alpha in Human Retinal Müller Cells
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Kim YJ, Park SJ, Kim NR, Chin HS
- KMID: 2368682
- Korean J Ophthalmol.
- 2017 Feb;31(1):80-85.
- doi: 10.3341/kjo.2017.31.1.80
PURPOSE: To evaluate the effects of valproic acid (VPA), a histone deacetylase inhibitor (HDACI), on the expression of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in human... -
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- Expression of Class I and Class II a/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models
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Kee HJ, Kim GR, Lin MQ, Choi SY, Ryu Y, Jin L, Piao ZH, Jeong MH
- KMID: 2385394
- Korean Circ J.
- 2017 May;47(3):392-400.
- doi: 10.4070/kcj.2016.0266
BACKGROUND AND OBJECTIVES: Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and... -
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- Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
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Min SK, Koh YH, Park Y, Kim HJ, Seo J, Park HR, Cho SJ, Kim IS
- KMID: 2011982
- Korean J Pathol.
- 2012 Apr;46(2):142-150.
BACKGROUND: It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma. METHODS:... -
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