Korean J Pathol.  2012 Apr;46(2):142-150.

Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas

• Min SK
• Koh YH
• Park Y
• Kim HJ
• Seo J
• Park HR
• Cho SJ
• Kim IS

Abstract

BACKGROUND
It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma.
METHODS
We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis.
RESULTS
The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p<0.05). The degree of the expression of HAT1 was correlated with that of HDAC1 in cases of DLBCL or NKTCL (p<0.05). The degree of the expression of HAT1 and HDAC1 was correlated with a poor survival in cases of DLBCL or PTCL-NOS (p>0.05).
CONCLUSIONS
HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.

Keyword

Acetylation; Deacetylation; Histone deacetylase inhibitors; Lymphoma

MeSH Terms

Acetylation
B-Lymphocytes
Blotting, Western
Histone Acetyltransferases
Histone Deacetylase Inhibitors
Histone Deacetylases
Histones
Immunohistochemistry
Lymphoma
Lymphoma, B-Cell
Lymphoma, T-Cell, Peripheral
Prognosis
Pseudolymphoma
Histone Acetyltransferases
Histone Deacetylase Inhibitors
Histone Deacetylases
Histones