- The Effects of Lipoxygenase and Cyclooxygenase Inhibitors to Meningioma Cell Proliferation in vitro
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Park YS, Koo TH, Lee JH, Lee YB, Lee KC, Mok JH, Kim HS
- KMID: 1546426
- J Korean Neurosurg Soc.
- 2000 Jan;29(1):28-34.
No abstract available. -
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- The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells
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Lim JC, Park SY, Nam Y, Nguyen TT, Sohn UD
- KMID: 1493963
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):313-320.
- doi: 10.4196/kjpp.2012.16.5.313
In this study, we focused to identify whether eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone), an extract from Artemisia argyi folium, prevents H2O2-induced injury of cultured feline esophageal epithelial cells. Cell viability was measured by... -
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- 5-Lipoxygenase Promotor Polymorphism in Nasal Polyp Patients
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Park SK, Choi JB, Jung H, Yea SS
- KMID: 2276733
- Korean J Otolaryngol-Head Neck Surg.
- 2007 Apr;50(4):310-313.
BACKGROUND AND OBJECTIVES: Nasal polyps are the most common mass lesions in the nasal cavity and occur on both infectious and noninfectious basis, and genetic etiology is suspected in the... -
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- Lipoxygenase Inhibitory Activity of Korean Indigenous Mushroom Extracts and Isolation of an Active Compound from Phellinus baumii
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Lee SW, Song JG, Hwang BS, Kim DW, Lee YJ, Woo EE, Kim JY, Lee IK, Yun BS
- KMID: 2312743
- Mycobiology.
- 2014 Jun;42(2):185-188.
We investigated a total of 335 samples of Korean native mushroom extracts as part of our lipoxygenase (LOX) inhibitor screening program. Among the mushroom-methanolic extracts we investigated, 35 exhibited an... -
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- Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
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Kanaoka Y, Boyce JA
- KMID: 2260208
- Allergy Asthma Immunol Res.
- 2014 Jul;6(4):288-295.
- doi: 10.4168/aair.2014.6.4.288
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties... -
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- Effects of Lipoxygenase Inhibitor on Diabetic Nephropathy in Rats: Decreasing Proteinuria and Preserving Renal Function
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Chung HC, Kim IY, Kim SR, Son J, Lee DW, Song SH, Seong EY, Kwak IS, Lee SB
- KMID: 2252632
- Korean J Nephrol.
- 2011 Sep;30(5):452-458.
PURPOSE: Oxidative stress leads to an increased production of lipoxygenase derivatives in diabetic nephropathy. Thus, we hypothesized that lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA), ha the effects of decreasing proteinuria and... -
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- Study on the action by PAF on IL-1 modulation in alveolar macrophages: Involvement of endogenous arachidonate metabolites and intracellular Ca++ mobilization
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Lee J, Kim WK, Hah JS
- KMID: 1562327
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):241-249.
Platelet-activating factor (PAF) enhanced interleukin-1 (IL-1) activity by the interaction with a specific receptor in rat alveolar macrophages. In this study, we investigated the role of endogenous arachidonate metabolites and intracellular calcium mobilization... -
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- Expression of Leukocyte-Type 12-Lipoxygenase in Murine Nasal Mucosa According to the Development
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Chun HS, Yoon JH, Lee JH, Lee YJ, Park TJ, Kim KS
- KMID: 2276335
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Jan;48(1):40-45.
BACKGROUND AND OBJECTIVES: We determined the localization of leukocyte-type 12-lipoxygenase (L-12-LO) in murine nasal mucosa and to investigate the expression of L-12-LO according to the development of murine nasal mucosa.... -
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- Downregulation of Angiotensin II-Induced 12-Lipoxygenase Expression and Cell Proliferation in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats by CCL5
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Kim JH, Kim HS
- KMID: 1982573
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):385-392.
- doi: 10.4196/kjpp.2009.13.5.385
Angiotensin II (Ang II) plays an important role in vascular hypertension. The role of the chemokine CCL5 on Ang II-induced activities in vascular smooth muscle cells (VSMCs) has not been... -
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- Enhanced Effect of Combinatorial Inhibition of Cyclooxygenase-2 and 5-Lipoxygenase on Head and Neck Cancer Cells
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Park SW, Sung MW
- KMID: 2037230
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Jul;53(7):430-435.
- doi: 10.3342/kjorl-hns.2010.53.7.430
BACKGROUND AND OBJECTIVES: It has recently been found that arachidonate 5-lipoxygenase (5-lipoxygenase, 5-LO or ALOX5), another molecule capable of arachidonic acid (AA) metabolism, might promote cancer cell viability through unique... -
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- LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-kappaB Pathways
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Lee SJ, Seo KW, Kim CD
- KMID: 1791428
- Korean J Physiol Pharmacol.
- 2015 May;19(3):263-268.
- doi: 10.4196/kjpp.2015.19.3.263
5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1... -
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- Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids
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Lee HS, Kim EJ, Oh YS, Cho HJ, Park JH
- KMID: 1804431
- Cancer Res Treat.
- 2001 Oct;33(5):404-413.
PURPOSE: Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of colon cancer is mediated through modulation of eicosanoid... -
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- 15-Lipoxygenase-1 Induced by Interleukin-4 Mediates Apoptosis in Oral Cavity Cancer Cells
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Kim JH, Lee JG, Yoon JH, Lee KW, Seo HS, Kim KS
- KMID: 2115502
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Dec;48(12):1512-1518.
BACKGROUND AND OBJECTIVES: In oral cavity cancer (OCC) cells, the effects of interleukin-4 (IL-4) are various according to the cell specificity. However, if IL-4 induces apoptosis on OCC cells, the... -
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- The Effects of Steroids and Nonsteroidal Antiinflammatory Agents on Proliferation of Human Ocular Fibroblast
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Lee JS, Jung W, Choi YR, Kim YS
- KMID: 2336862
- J Korean Ophthalmol Soc.
- 1999 Jun;40(6):1496-1502.
Corticosteroid, 5-fluorouracil and Mitomycin C(MMC) have been used to suppress proliferation of subconjunctival connective tissue. However, the various complication and undesirable side effects associated with the use of these drugs... -
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- Ia + Keratinocyte
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Houh W
- KMID: 2039031
- Korean J Dermatol.
- 1987 Feb;25(1):1-7.
Ia antigen (HLA-DR in rnan) is confined to the Langerhans cells and indeterminate cells in the normal epidermis in man. However the keratinocyte express la antigen in a variety of... -
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- IL-8/CXCL8 Upregulates 12-Lipoxygenase Expression in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats
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Kim JH, Kang YJ, Kim HS
- KMID: 2150649
- Immune Netw.
- 2009 Jun;9(3):106-113.
- doi: 10.4110/in.2009.9.3.106
BACKGROUND: We previously demonstrated remarkable differences in the expression of IL-8/CXCL8 in aortic tissues and vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) compared to VSMC from normotensive... -
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- Rhamnazin inhibits LPS-induced inflammation and ROS/RNS in raw macrophages
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Kim YJ
- KMID: 2357131
- J Nutr Health.
- 2016 Oct;49(5):288-294.
- doi: 10.4163/jnh.2016.49.5.288
PURPOSE: The aim of this work was to investigate the beneficial effects of rhamnazin against inflammation, reactive oxygen species (ROS)/reactive nitrogen species (RNS), and anti-oxidative activity in murine macrophage RAW264.7... -
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- Leukotriene related gene polymorphisms in ASA-intolerant asthma: an association of 5-lipoxygenase haplotype
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Choi JH, Park HS, Shin SS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD
- KMID: 2178419
- J Asthma Allergy Clin Immunol.
- 2003 Dec;23(4):800-809.
BACKGROUND AND OBJECTIVES: A recent study has demonstrated a possible involvement of leukotriene C4 synthase (LTC4S) gene polymorphism in ASA-intolerant asthma (AIA) in a Polish population, while no significances were... -
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- Benzoxazole Derivative B-98 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis and the Change of T Cell Profiles in Acute Murine Colitis Model
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Song EM, Jung SA, Lee JS, Kim SE, Shim KN, Jung HK, Yoo K, Park HY
- KMID: 1711277
- Korean J Gastroenterol.
- 2013 Jul;62(1):33-41.
- doi: 10.4166/kjg.2013.62.1.33
BACKGROUND/AIMS: The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to... -
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- Expression of Endothelin-1 by Stimulation with CXCL8 in Mouse Peritoneal Macrophages
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Bae JJ, Kim JH, Kim H, Kim HS
- KMID: 1474163
- J Bacteriol Virol.
- 2009 Sep;39(3):205-216.
- doi: 10.4167/jbv.2009.39.3.205
Endothelin-1 (ET-1) has been characterized as a potent vasoconstrictor secreted by the endothelium, and play a major role in the regulation of vascular tone. It has been also known to... -
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