Korean J Dermatol.  1987 Feb;25(1):1-7.

Ia + Keratinocyte

• Houh W

Abstract

Ia antigen (HLA-DR in rnan) is confined to the Langerhans cells and indeterminate cells in the normal epidermis in man. However the keratinocyte express la antigen in a variety of dermatoses. IFN-r (irnmune interfcron), known as macrophage activating factor, has been shown to induce Ia antigen expression in a wide variety of cell types. However the Ia antigen induced by 1FN-r is inhibited PGE2, a product of cyclooxygenase pathway of arachidonic acid metabolism. LTB4, a product of lipoxygenase pathway, can replace the IL-2 requirement for IFN-r production in the lymphocytes. There are three main morphalogical patterns of Ia antigen staining in the epidennis. Staining of the basal cells, staining in the mid epidermis in Malphigian layer and staining throughout the epidermis. The staining of Ia' keratinocyte was found to be confined to the lesional area of contact hypersensitivity reaction, graft vs host disease, and lichen planus. la+staining to extend beyond the lesional area was also seen in the study on turberculosis and leporsy.

Keyword

IFN - gamma; Ia + Keratinocyte; IL - 1; ETAF; PGE2; LTB4; HLA - DR / Ia antigen; MLR; UVR; CHS

MeSH Terms

Arachidonic Acid
Dermatitis, Contact
Dinoprostone
Epidermis
Graft vs Host Disease
Histocompatibility Antigens Class II
Interleukin-2
Keratinocytes*
Langerhans Cells
Leukotriene B4
Lichen Planus
Lipoxygenase
Lymphocytes
Macrophages
Metabolism
Prostaglandin-Endoperoxide Synthases
Skin Diseases
Arachidonic Acid
Dinoprostone
Histocompatibility Antigens Class II
Interleukin-2
Leukotriene B4
Lipoxygenase
Prostaglandin-Endoperoxide Synthases