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Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes

Lee J, Jang A, Seo SJ, Myung SC

BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor...
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Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin

Espósito , Brianezi G, de Souza N, Miot LD, Miot HA

BACKGROUND: Melasma is a chronic acquired focal hypermelanosis which pathogenesis has not been fully elucidated. Classical pathophysiologic studies have analysed the affected and perilesional areas, but little is known about...
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Eccrine Syringofibroadenoma Associated with Bowen's Disease: A Case Report and Review of the Literature

Lee JS, Park H, Yoon HS, Cho S

Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal neoplasm which usually manifests as a solitary nodule on the extremities of elderly patients. Few case reports have described an association between...
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Nailbed malignant melanoma in three dogs

Three 8-12-year-old male cocker spaniels presented with an appendicular mass accompanied by pain, inflammation, lameness, and loss of nail in the digits of the forelimb or hindlimb. A histological examination...
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Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes

Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS

Particulate matter (PM), which refers to the mixture of particles present in the air, can have harmful effects. Damage to cells by PM, including disruption of organelles and proteins, can...
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Rab25 Deficiency Perturbs Epidermal Differentiation and Skin Barrier Function in Mice

Jeong H, Lim KM, Goldenring JR, Nam KT

Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast,...
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A Case of Immunoglobulin A Pemphigus: Intraepidermal Neutrophilic Dermatosis Type

Heo JH, Yoon HS, Lee SH, Yeom SD, Kim L, Kim SC, Byun JW, Shin J, Choi GS

  • KMID: 2465959
  • Korean J Dermatol.
  • 2019 Sep;57(8):492-495.
Immunoglobulin A (IgA) pemphigus is a rare variant of an autoimmune bullous disease with IgA antibodies. IgA pemphigus is divided into 2 major subtypes: the subcorneal pustular dermatosis (SPD) type...
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Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model

Kim M, Jeong H, Lee B, Cho Y, Yoon WK, Cho A, Kwon G, Nam KT, Ha H, Lim KM

Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in...
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Mammary Paget's Disease of the Nipple: Relatively Common but Still Unknown to Many

Ooi PS, Draman N, Yusoff SS, Zain WZ, Ganasagaran D, Chua HH

Mammary Paget's disease is clinically defined as skin inflammation of the nipple area and is an adenocarcinoma of the epidermis of the nipple. The pathogenesis of mammary Paget's disease is...
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Acquired Reactive Perforating Collagenosis as a Preceding Manifestation of Hodgkin's Lymphoma

Lee SY, Bang CH, Park YM, Lee JY, Lee JH

  • KMID: 2454375
  • Korean J Dermatol.
  • 2019 Jul;57(6):332-334.
A 40-year-old man presented with pruritic, multiple, variable-sized, erythematous umbilicated papules on the trunk and both extremities for 4 months. He was diagnosed with Hodgkin's lymphoma (stage IIA) after histopathologic...
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Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

Seo HS, Seong KH, Kim CD, Seo SJ, Park BC, Kim MH, Hong SP

BACKGROUND: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various...
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Neuropeptides Profile and Increased Innervation in Becker's Nevus

Kim JS, Park MJ, Kang HY, Hong SP, Park BC, Kim MH

BACKGROUND: Melanocytes are derived from neural crest, and various pigmentary disorders may accompany abnormalities in nerve system or develop following dermatome, suggesting that melanocyte and pigmentation may be closely related...
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Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes

Bae IH, Lee SH, Oh S, Choi H, Marinho PA, Yoo JW, Ko JY, Lee ES, Lee TR, Lee CS, Kim DY

Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the...
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Anti-tuberculosis Drugs-induced Anagen Effluvium with Generalized Drug Eruption

Lim C, Park KD, Seo YJ, Lee J, Lee Y

  • KMID: 2433638
  • Korean J Dermatol.
  • 2019 Jan;57(1):15-19.
Anagen effluvium is an abrupt loss of hair in its growing phase due to an event that impairs the mitotic or metabolic activity of the hair follicle. Anagen effluvium is...
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Reconstruction of cutaneous defects of the nasal tip and alar by two different methods

Kim YH, Yoon HW, Chung S, Chung YK

BACKGROUND: The alar and nasal tip are important subunits of the nose. Determining the optimal procedure for reconstructing a cutaneous defect in a nasal subunit depends on several factors including...
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From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis

Jin M, Yoon J

Atopic dermatitis (AD) is the most common pruritic inflammatory skin disease characterized by thickening of epidermis and dermis as well as by the infiltration of multiple pathogenic polarized T lymphocytes,...
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The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate

Chae JB, Choi HR, Shin JW, Na JI, Huh CH, Park KC

BACKGROUND: Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a flavonoid known to have a wide range of pharmacological activities. The 3-OH group in flavonoids has been reported to determine antioxidant activities. OBJECTIVE: We tested whether...
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Pathophysiology and new treatment of itch

Jung MJ, Choi YW, Chung BY, Park CW, Kim HO

Many of the patients visit the doctors because of itching sensation. Itching is an unpleasant sensation. In the epidermal keratinocytes, various neurotransmitters and receptors are related itching. The itch signal...
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Medical adhesive related skin injury after dental surgery

Kim TH, Lee JS, Ahn JH, Kim CH, Yoon JU, Kim EJ

An 87-year-old woman was referred for the extraction of residual teeth and removal of tori prior to prosthetic treatment. After surgery under general anesthesia, the surgical tape was removed to...
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Clinical and Histopathologic Study of Confluent and Reticulated Papillomatosis by Anatomic Site and Age

Cho YM, Jung KE, Koo DW, Lee JS

BACKGROUND: Confluent and reticulated papillomatosis (CRP) is an uncommon dermatosis characterized by hyperpigmented scaly macules or papillomatous papules coalescing into confluent patches or plaques centrally with a reticular pattern peripherally....
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