Ann Dermatol.
1995 Apr;7(2):169-171. 10.5021/ad.1995.7.2.169.
Enhanced Expression of Proliferating Cell Nuclear Antigen in Psoriatic Epidermis
- KMID: 2383076
- DOI: http://doi.org/10.5021/ad.1995.7.2.169
Abstract
- BACKGROUND
The proliferating cell nuclear antigen(PCNA), one of the markers for proliferating cells, has been detected in solid human neoplasms. Psoriasis is a benign hyperproliferative disorder of the skin.
OBJECTIVE
This study has been made to investigate if PCNA can be detected in the psoriatic epidermis.
METHODS
Specimens from 10 patients with psoriasis were stained for PCNA using the one hour immunoalkaline phosphatase technique.
RESULTS
The psoriatic epidermis showed positive nuclear staining in 20%-61% (mean, 45.7%) of keratinocytes.
CONCLUSION
PCNA seems to be involved in the mechanism of increased epidermal cell proliferation in psoriatic lesions.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- IMMUNOHISTOCHEMICAL STUDY OF Ki-67 AND PROLIFERATING CELL NUCLEAR ANTIGEN EXPRESSION IN MALIGNANT MELANOMA
- Expression of p53, pRb, p16, p21 and PCNA on Psoriatic Epidermis
- The Changes of Telomerase Activity and Proliferating Cell Nuclear Antigen (PCNA) Expression in the Developmental Stages of Rat Kidney
- Reduced Expression of Cyclins and Proliferative Indices on the Psoriatic Epidermis after 12 Weeks of Oral Cyclosporin Therapy
- The study on the expression of proliferating cell nuclear antigen and c-H-ras oncogene product in multiple myeloma
