Korean J Otolaryngol-Head Neck Surg.  1997 Jan;40(1):56-62.

Hyperproliferative Characteristics in Human Deep Meatal Epidermis

• Chun YM
• Park KH

Abstract

In benign hyperproliferative epidermal diseases(eq. warts, psoriasis) and squamous carcinoma, some molecular markers of hyperproliferative keratinocyte such as cytokeratin 16 and PCNA were expressed predominantly. However, all healthy epidermis including the meatal epidermis are nonreactive to those molecular markers except some of thick skin. Recently, there are several reports which show unusal proliferative capacity around the annular region of the ear drum. Our study has concentrated on the characteristics of the differentiation in healthy deep meatal epidermis using immunohistochemistry with cytokeratins and PCNA. Our investigation has demonstrated that the deep meatal epidermis around the annular region in contrast to the other region of the meatus exhibited unusal proliferative capacity. This result suggests a pathology link such as invasion mechanism and hyperkeratinization between the cholesteatoma and deep meatal skin.

Keyword

Cytokeratin; Deep meatal skin; Hyperproliferation; PCNA

MeSH Terms

Carcinoma, Squamous Cell
Cholesteatoma
Ear
Epidermis*
Humans*
Immunohistochemistry
Keratin-16
Keratinocytes
Keratins
Pathology
Proliferating Cell Nuclear Antigen
Skin
Warts
Keratin-16
Keratins
Proliferating Cell Nuclear Antigen