- Cerebral Venous Thrombosis Presenting in Pregnancy with Thrombocytosis and Janus Kinase 2 Valine-to-Phenylalanine Mutation
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Yoon SJ, Woo MH, Chung D, Kim J
- KMID: 2436076
- J Korean Neurol Assoc.
- 2018 Aug;36(3):192-195.
- doi: 10.17340/jkna.2018.3.10
A 30-year-old woman in her first pregnancy was admitted with headache and horizontal diplopia indicating left abducens nerve palsy. Brain magnetic resonance imaging revealed a cerebral venous thrombosis. She had... -
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- Rapidly Growing and Aggressive Cutaneous Squamous Cell Carcinomas in a Patient Treated with Ruxolitinib
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March-Rodriguez A, Bellosillo B, Ãlvarez-Larrán A, Besses C, Pujol RM, Toll A
- KMID: 2439067
- Ann Dermatol.
- 2019 Apr;31(2):204-208.
- doi: 10.5021/ad.2019.31.2.204
Ruxolitinib is a Janus kinase (JAK)1 and JAK2 inhibitor approved for the treatment of myelofibrosis and for polycythemia patients who are resistant or intolerant to hydroxyurea. We report a 72... -
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- A Rare Case of Polycythemia Vera Following Acute Undifferentiated Leukemia Remission
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Youk HJ, Cho CH, Lee JH, Choi CW, Lim CS, Yoon SY
- KMID: 2129574
- Ann Lab Med.
- 2014 Nov;34(6):469-470.
- doi: 10.3343/alm.2014.34.6.469
No abstract available. -
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- Ischemic Stroke with Extracranial Internal Carotid Artery Occlusion in Essential Thrombocythemia with JAK-2 Mutation
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Lee JE, Jung AR, Choi JH, Kim TK, Kwon E, Lee CY, Chun MY, Chang Y, Kim YJ, Song TJ
- KMID: 2359456
- J Korean Neurol Assoc.
- 2016 Nov;34(5):384-387.
- doi: 10.17340/jkna.2016.4.19
In essential thrombocythemia (ET), cerebral infarction with large cerebral artery occlusion has rarely been reported. A 53-year-old male was admitted with left sided weakness. Brain magnetic resonance images revealed right... -
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- Straightforward Identification of Masked Polycythemia Vera Based on Proposed Revision of World Health Organization Diagnostic Criteria for BCR-ABL1-Negative Myeloproliferative Neoplasms
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Chu D, Cho YU, Jang S, Seo EJ, Park CJ
- KMID: 2363272
- Ann Lab Med.
- 2015 Nov;35(6):651-653.
- doi: 10.3343/alm.2015.35.6.651
No abstract available. -
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- A t(8;9)(p22;p24)/PCM1-JAK2 Translocation in a Patient With Myeloproliferative Neoplasm and Myeloid Sarcoma: First Report in Korea
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Song I, Lee DH, Lee JH, Jang S, Huh JR, Seo EJ
- KMID: 2373505
- Ann Lab Med.
- 2016 Jan;36(1):79-81.
- doi: 10.3343/alm.2016.36.1.79
No abstract available. -
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- Correlations between Janus Kinase 2 V617F Allele Burdens and Clinicohematologic Parameters in Myeloproliferative Neoplasms
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Ha JS, Kim YK, Jung SI, Jung HR, Chung IS
- KMID: 2434478
- Ann Lab Med.
- 2012 Nov;32(6):385-391.
BACKGROUND: This study evaluated potential correlations between the allele burden of the Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients with myeloproliferative neoplasms (MPN). METHODS: Clinical and hematologic... -
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- Calreticulin Exon 9 Mutations in Myeloproliferative Neoplasms
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Ha JS, Kim YK
- KMID: 2363143
- Ann Lab Med.
- 2015 Jan;35(1):22-27.
- doi: 10.3343/alm.2015.35.1.22
BACKGROUND: Calreticulin (CALR) mutations were recently discovered in patients with myeloproliferative neoplasms (MPNs). We studied the frequency and type of CALR mutations and their hematological characteristics. METHODS: A total of 168... -
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- Peroxisome Proliferator-activated Receptor-gamma Inhibits the Activation of STAT3 in Cerulein-stimulated Pancreatic Acinar Cells
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Ju KD, Lim JW, Kim H
- KMID: 2396168
- J Cancer Prev.
- 2017 Sep;22(3):189-194.
- doi: 10.15430/JCP.2017.22.3.189
Cerulein-induced pancreatitis is similar to human edematous pancreatitis, characterized by the dysregulation of digestive enzyme production, edema formation, and an infiltration of inflammatory cells into the pancreas. We previously showed... -
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- The allele burden of JAK2 V617F can aid in differential diagnosis of Philadelphia Chromosome-Negative Myeloproliferative Neoplasm
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Park SH, Chi HS, Cho YU, Jang S, Park CJ
- KMID: 2172911
- Blood Res.
- 2013 Jun;48(2):128-132.
- doi: 10.5045/br.2013.48.2.128
BACKGROUND: We aimed to evaluate the feasibility of using the allele burden of Janus kinase 2 (JAK2) V617F as a criterion for discriminating 3 subtypes of Philadelphia chromosome-negative myeloproliferative neoplasm... -
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- A Case of Atypical Chronic Myeloid Leukemia with the JAK2V617F Mutation
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Kim JY, Lee SR, Nam MH, Yoon SY, Lim CS, Lee CK, Kim BS, Cho Y, Kim YK, Lee KN
- KMID: 1993642
- Lab Med Online.
- 2011 Oct;1(4):232-236.
- doi: 10.3343/lmo.2011.1.4.10
Atypical chronic myeloid leukemia (aCML) is a rare leukemic disorder that shows myelodysplastic and myeloproliferative features simultaneously. The Janus kinase 2 gene V617F mutation (JAK2V617F) in aCML has been the... -
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- Two Cases of Myeloproliferative Neoplasm with a Concurrent JAK2V617F Mutation and BCR/ABL Translocation without Chronic Myelogenous Leukemia Phenotype Acquisition during Hydroxyurea Treatment
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Park SH, Chi HS, Cho YU, Jang S, Park CJ, Kim DY, Lee JH, Lee KH
- KMID: 1781334
- Ann Lab Med.
- 2013 May;33(3):229-232.
- doi: 10.3343/alm.2013.33.3.229
No abstract available. -
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- Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130
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Seo IA, Lee HK, Shin YK, Lee SH, Seo SY, Park JW, Park HT
- KMID: 2071662
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):131-138.
- doi: 10.4196/kjpp.2009.13.2.131
The binding of interleukin-6 (IL-6) cytokine family ligands to the gp130 receptor complex activates the Janus kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signal transduction pathway,... -
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- Characterization of JAK2 V617F (1849 G > T) Mutation in Cervical Cancer Related to Human Papillomavirus and Sexually Transmitted Infections
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Abdolmaleki M, Sohrabi A
- KMID: 2417371
- J Cancer Prev.
- 2018 Jun;23(2):82-86.
- doi: 10.15430/JCP.2018.23.2.82
BACKGROUND: Human papillomavirus (HPV) genotypes that infect the genital tract play a main etiologic role in cervical cancer progression. Other environmental factors, such as sexually transmitted diseases and the host... -
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- Effect of Angiotensin II on Gene Expression of cGMP-Specific Phosphodiesterases
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Kim D, Hong BK, Kwon HM, Kim DY, Cho YH, Yoon SJ, Kim HS, Yan C
- KMID: 2029615
- Korean Circ J.
- 2003 Feb;33(2):130-138.
- doi: 10.4070/kcj.2003.33.2.130
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) opposes the actions of nitric oxide (NO). A balance between Ang II and NO is critical for the maintenance of normal vessel tone,... -
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- The Effect of IGFBP-3 on Adipokines and Gene Expression in Differentiated 3T3-L1 Adipocytes
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Kim HS
- KMID: 1450620
- J Korean Soc Pediatr Endocrinol.
- 2011 Apr;16(1):24-30.
- doi: 10.6065/jkspe.2011.16.1.24
PURPOSE: IGFBP-3 leads to the induction of insulin resistance in 3T3-L1 adipocytes. We carried out a series of experiments to elucidate the effects of IGFBP-3 on adipokines and gene expressions. METHODS:... -
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- Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling
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Kim BH, Yi EH, Li YC, Park IC, Park JY, Ye SK
- KMID: 2458858
- J Breast Cancer.
- 2019 Sep;22(3):362-374.
- doi: 10.4048/jbc.2019.22.e34
PURPOSE: The chemical structure of tubulosine has been known since the mid-1960s. However, little is known about its biological and pharmacological functions. The aim of this study was to investigate... -
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- Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3
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Li D, Yan Y, Yu L, Duan Y
- KMID: 2351672
- Biomol Ther.
- 2016 Sep;24(5):489-494.
- doi: 10.4062/biomolther.2016.006
Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its... -
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- Diagnostic Usefulness of the Janus Kinase 2 Mutation in non BCR/ABL Myeloproliferative Disorders
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Bang SM, Ahn JY, Park J, Yoo SJ, Park SH, Nam EM, Park PW, Seo YH, Cho EK, Shin DB, Lee JH
- KMID: 759854
- Korean J Intern Med.
- 2006 Dec;21(4):219-224.
- doi: 10.3904/kjim.2006.21.4.219
BACKGROUND: We investigated the Janus kinase 2 (JAK2) mutation and its diagnostic value in patients suffering with non BCR/ABL myeloproliferative diseases (nMPD) or other reactive conditions. METHODS: We... -
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- Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer Cells
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Narayanan , Nandabalan SK, Baddireddi LS
- KMID: 2308962
- J Breast Cancer.
- 2016 Jun;19(2):122-132.
- doi: 10.4048/jbc.2016.19.2.122
PURPOSE: In this study, we investigated the molecular mechanism involved in ethanol (EtOH)-mediated proliferation of breast cancer cells. METHODS: EtOH concentration was optimized by studying its effect on cell proliferation in... -
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