J Korean Neurol Assoc.
2018 Aug;36(3):192-195. 10.17340/jkna.2018.3.10.
Cerebral Venous Thrombosis Presenting in Pregnancy with Thrombocytosis and Janus Kinase 2 Valine-to-Phenylalanine Mutation
- Affiliations
-
- 1Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Korea. kimjinkwon@cha.ac.kr
- KMID: 2436076
- DOI: http://doi.org/10.17340/jkna.2018.3.10
Abstract
- A 30-year-old woman in her first pregnancy was admitted with headache and horizontal diplopia indicating left abducens nerve palsy. Brain magnetic resonance imaging revealed a cerebral venous thrombosis. She had thrombocytosis in the peripheral blood, and a genetic test for thrombocytosis revealed the presence of the valine-to-phenylalanine (V617F) mutation of the Janus kinase 2 (JAK2) gene. Treatment with low-molecular-weight heparin resolved her symptoms of headache and diplopia. The presence of genetic disorders such as the JAK2-V617F gene mutation should be assessed in patients with cerebral venous thrombosis and coexisting thrombocytosis.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Cerebral Venous Thromobosis Associated with Postsplenectomy Thrombocytosis
- Ischemic Stroke with Extracranial Internal Carotid Artery Occlusion in Essential Thrombocythemia with JAK-2 Mutation
- A Case of Essential Thrombocythemia Presenting as Esophageal Varix Bleeding and Multiple Thrombosis
- A Case of Deep Cerebral Venous Thrombosis Associated with Iron Deficiency Anemia
- A Case of Deep Cerebral Vein Thrombosis during Pregnancy
