- Maturation of Stem Cell-Derived Cardiomyocytes: Foe in Translation Medicine
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Liao Y, Zhu L, Wang Y
- KMID: 2522557
- Int J Stem Cells.
- 2021 Nov;14(4):366-385.
- doi: 10.15283/ijsc21077
With the in-depth study of heart development, many human cardiomyocytes (CMs) have been generated in a laboratory environment. CMs derived from pluripotent stem cells (PSCs) have been widely used for... -
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- Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight
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Ghollasi M, Ghasembaglou S, Rahban D, Korani M, Motallebnezhad M, Asadi M, Zarredar H, Salimi A
- KMID: 2522556
- Int J Stem Cells.
- 2021 Nov;14(4):351-365.
- doi: 10.15283/ijsc20146
The interactions between the tumor microenvironment and the tumor cells confers a condition that accelerate or decelerate the development of tumor. Of these cells, mesenchymal stem cells (MSCs) have the... -
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- Human Liver Stem Cell Transplantation Alleviates Liver Fibrosis in a Rat Model of CCl 4 -Induced Liver Fibrosis
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Lee JH, Lee S, Park HJ, Kim YA, Lee SK
- KMID: 2522565
- Int J Stem Cells.
- 2021 Nov;14(4):475-484.
- doi: 10.15283/ijsc21031
Background and Objectives: Mesenchymal stem cells (MSCs) elicit therapeutic effects against liver fibrosis in animal models. Human liver stem cells (HLSCs) are cells isolated from human liver tissue that have... -
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- Targeting Cancer Stem Cell Markers or Pathways: A Potential Therapeutic Strategy for Oral Cancer Treatment
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Lee JW, Lee HY
- KMID: 2522558
- Int J Stem Cells.
- 2021 Nov;14(4):386-399.
- doi: 10.15283/ijsc21084
Cancer stem cells (CSCs) are a small subset of cancer cells with stem cell-like properties, self-renewal potential, and differentiation capacity into multiple cell types. Critical genetic alterations or aberrantly activated... -
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- MiR-148a-3p Regulates the Invasion and Odontoblastic Differentiation of Human Dental Pulp Stem Cells via the Wnt1/β-Catenin Pathway
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Li Q, Huang L
- KMID: 2522562
- Int J Stem Cells.
- 2021 Nov;14(4):434-446.
- doi: 10.15283/ijsc20118
Background and Objectives: MiR-148a-3p has been reported to regulate the differentiation of marrow stromal cell osteoblast. In this study, whether miR-148a-3p regulated the odontoblastic differentiation of human dental pulp... -
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- Irisin Enhances Angiogenesis of Mesenchymal Stem Cells to Promote Cardiac Function in Myocardial Infarction via PI3k/Akt Activation
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Yang F, Wang Z, Li B, He Y, Du F, Tian S, Zhang Y, Yang Y
- KMID: 2522563
- Int J Stem Cells.
- 2021 Nov;14(4):455-464.
- doi: 10.15283/ijsc21005
Background and Objectives: With the growing incidence of acute myocardial infarction (MI), angiogenesis is vital for cardiac function post-MI. The role of bone marrow mesenchymal stem cells (BMSCs) in angiogenesis... -
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- Sox9 Is Crucial for Mesenchymal Stem Cells to Enhance Cutaneous Wound Healing
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Bie Q, Zhai R, Chen Y, Li Y, Xie N, Wang B, Yuan P, Zhou X, Cong H, Chang X, Xiong H, Zhang B
- KMID: 2522564
- Int J Stem Cells.
- 2021 Nov;14(4):465-474.
- doi: 10.15283/ijsc21078
Background and Objectives: Human umbilical cord mesenchymal stem cells (HUC-MSCs) are promising candidates for cell-based therapy in regenerative medicine or other diseases due to their superior characteristics, including higher proliferation,... -
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- miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1
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Zhang Y, He Y, Wu P, Hu S, Zhang Y, Chen C
- KMID: 2522561
- Int J Stem Cells.
- 2021 Nov;14(4):423-433.
- doi: 10.15283/ijsc21080
Background and Objectives: Sheep-induced pluripotent stem cells (siPSCs) have low reprogramming efficiency, thereby hampering their use in biotechnology and agriculture. Several studies have shown that some microRNAs play an important... -
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- Hypoxic Pretreatment of Adipose-Derived Stem Cells Accelerates Diabetic Wound Healing via circ-Gcap14 and HIF-1α/VEGF Mediated Angiopoiesis
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Wang Z, Feng C, Liu H, Meng T, Huang W, Long X, Wang X
- KMID: 2522566
- Int J Stem Cells.
- 2021 Nov;14(4):447-454.
- doi: 10.15283/ijsc21050
Background and Objectives: Adipose-derived stem cell (ADSC) transplantation improves stem cell paracrine function and can enhance wound healing. However, in diabetic patients, glucose-associated effects on this function and cell survival... -
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- Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia
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Park S, Kim HJ, Hwang HS, Han AR
- KMID: 2522559
- Int J Stem Cells.
- 2021 Nov;14(4):400-409.
- doi: 10.15283/ijsc21083
Background and Objectives: The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M),... -
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- p53 Promotes Differentiation of Cardiomyocytes from hiPSC through Wnt Signaling-Mediated Mesendodermal Differentiation
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Liu Y, Zhang P, Huang W, Liu F, Long D, Peng W, Dang X, Zeng X, Zhou R
- KMID: 2522560
- Int J Stem Cells.
- 2021 Nov;14(4):410-422.
- doi: 10.15283/ijsc21051
Background and Objectives: Manipulating different signaling pathways via small molecules could efficiently induce cardiomyocytes from human induced pluripotent stem cells (hiPSC). However, the effect of transcription factors on the hiPSC-directed cardiomyocytes... -
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