- Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion
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Chatla S, Wilson AF, Pang Q
- KMID: 2465886
- Int J Stem Cells.
- 2019 Nov;12(3):457-462.
- doi: 10.15283/ijsc19074
Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and high risk of cancer particularly leukemia. Here we show that inactivation of the non-homologous end-joining (NHEJ) activity... -
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- Adult Stem Cells in Hibernation: Future Perspectives of Space Travel
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Chen YC, Aui SP, Lai YS, Chang KT
- KMID: 2465878
- Int J Stem Cells.
- 2019 Nov;12(3):381-387.
- doi: 10.15283/ijsc19048
Space traveling is imperative for mankind in the future. Expectedly, hibernation will become an option for space traveler to overcome the endless voyage. With regard to some of the studies... -
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- Maintenance of hPSCs under Xeno-Free and Chemically Defined Culture Conditions
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Lim JJ, Kim HJ, Rhie BH, Lee MR, Choi MJ, Hong SH, Kim KS
- KMID: 2465889
- Int J Stem Cells.
- 2019 Nov;12(3):484-496.
- doi: 10.15283/ijsc19090
Previously, the majority of human embryonic stem cells and human induced pluripotent stem cells have been derived on feeder layers and chemically undefined medium. Those media components related to feeder... -
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- Reprogramming of Cancer Cells into Induced Pluripotent Stem Cells Questioned
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Bang JS, Choi NY, Lee M, Ko K, Park YS, Ko K
- KMID: 2465883
- Int J Stem Cells.
- 2019 Nov;12(3):430-439.
- doi: 10.15283/ijsc19067
BACKGROUND AND OBJECTIVES: Several recent studies have claimed that cancer cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, in most cases, cancer cells seem to be resistant... -
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- Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson’s Disease Patients
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Lee M, Sim H, Ahn H, Ha J, Baek A, Jeon YJ, Son MY, Kim J
- KMID: 2465888
- Int J Stem Cells.
- 2019 Nov;12(3):474-483.
- doi: 10.15283/ijsc19075
In Parkinson’s disease (PD) research, human neuroblastoma and immortalized neural cell lines have been widely used as in vitro models. The advancement in the field of reprogramming technology has provided... -
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- Role of a 19S Proteasome Subunit- PSMD10(Gankyrin) in Neurogenesis of Human Neural Progenitor Cells
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Sahu I, Nanaware P, Mane M, Mulla SW, Roy S, Venkatraman P
- KMID: 2465887
- Int J Stem Cells.
- 2019 Nov;12(3):463-473.
- doi: 10.15283/ijsc19007
PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function... -
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- Perivascular Stem Cells Suppress Inflammasome Activation during Inflammatory Responses in Macrophages
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Kim J, Kim WJ, Ha KS, Han ET, Park WS, Yang SR, Hong SH
- KMID: 2465882
- Int J Stem Cells.
- 2019 Nov;12(3):419-429.
- doi: 10.15283/ijsc19115
BACKGROUND AND OBJECTIVES: Perivascular stem cells (PVCs) have been identified as precursors of mesenchymal stem cells (MSCs) that offer promising prospects for application in the development of cellular therapies. Although... -
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- Comparison of the Cardiomyogenic Potency of Human Amniotic Fluid and Bone Marrow Mesenchymal Stem Cells
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Jain M, Minocha E, Tripathy N, Singh N, Chaturvedi CP, Nityanand
- KMID: 2465885
- Int J Stem Cells.
- 2019 Nov;12(3):449-456.
- doi: 10.15283/ijsc18087
BACKGROUND AND OBJECTIVES: Most studies in cardiac regeneration have explored bone marrow mesenchymal stem cells (BM-MSC) with variable therapeutic effects. Amniotic fluid MSC (AF-MSC) having extended self-renewal and multi-potent properties... -
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- Regeneration of Neural Networks in Immature Teeth with Non-Vital Pulp Following a Novel Regenerative Procedure
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Mounir MM, Rashed FM, Bukhary SM
- KMID: 2465881
- Int J Stem Cells.
- 2019 Nov;12(3):410-418.
- doi: 10.15283/ijsc19026
BACKGROUND AND OBJECTIVES: Recombinant amelogenin protein (RAP) was reported to induce soft-tissue regeneration in canine infected endodontically treated permanent teeth with open apices. To characterize identities of the cells found... -
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- The Effect of Mesenchymal Stem Cells Derived Microvesicles on the Treatment of Experimental CCL4 Induced Liver Fibrosis in Rats
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Sabry D, Mohamed A, Monir M, Ibrahim HA
- KMID: 2465880
- Int J Stem Cells.
- 2019 Nov;12(3):400-409.
- doi: 10.15283/ijsc18143
BACKGROUND AND OBJECTIVES: The release of microvesicles (MVs) from mesenchymal stem cells (MSCs) has been implicated in intercellular communication, and may contribute to beneficial paracrine effects of stem cell-based therapies.... -
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- Immunosuppressive Effect of Exosomes from Mesenchymal Stromal Cells in Defined Medium on Experimental Colitis
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Ma ZJ, Wang YH, Li ZG, Wang Y, Li BY, Kang HY, Wu XY
- KMID: 2465884
- Int J Stem Cells.
- 2019 Nov;12(3):440-448.
- doi: 10.15283/ijsc18139
BACKGROUND AND OBJECTIVES: The exosomes released by mesenchymal stromal cells (MSCs) in classical FBS-containing media have been demonstrated as an alternative, cell-free therapy in various diseases including inflammatory bowel disease... -
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- Improvement of Human Sperm Vacuolization and DNA Fragmentation Co-Cultured with Adipose-Derived Mesenchymal Stem Cell Secretome: In Vitro Effect
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Bader R, Ibrahim JN, Mourad A, Moussa M, Azoury J, Azoury J, Alaaeddine N
- KMID: 2465879
- Int J Stem Cells.
- 2019 Nov;12(3):388-399.
- doi: 10.15283/ijsc19047
BACKGROUND AND OBJECTIVES: Oxidative stress (OS) is known to be an important factor of male infertility. Adipose-derived mesenchymal stem cells (AD-MSCs) are known to have immune-modulatory and anti-oxidant effects through... -
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