Int J Stem Cells.  2019 Nov;12(3):381-387. 10.15283/ijsc19048.

Adult Stem Cells in Hibernation: Future Perspectives of Space Travel

• Chen YC
• Aui SP
• Lai YS
• Chang KT

• KMID: 2465878
• DOI: http://doi.org/10.15283/ijsc19048

Abstract

Space traveling is imperative for mankind in the future. Expectedly, hibernation will become an option for space traveler to overcome the endless voyage. With regard to some of the studies pointed out that during hibernation, muscle will undergo atrophy and meantime neurogenesis will reduce, these obstacles were frequently related with stem cell regeneration. Thus, investigation on whether hibernation will lead to dysfunction of stem cell becomes an important issue. By going through four main systems in this article, such as, hematopoietic system, skeletal muscle system, central nervous system and orthopedic system, we are expecting that stem cells regeneration capacity will be affected by hibernation. To date, these researches are majorly the read-out from short term or seasonal hibernating mammals. Proposing and creating a simulated long-term hibernation animal model is turning essential for the further investigation on the effect of longer period of hibernation to human stem cells.

Keyword

Stem cell; Hibernation; Torpor; Arousal

MeSH Terms

Adult Stem Cells*
Adult*
Arousal
Atrophy
Central Nervous System
Hematopoietic System
Hibernation*
Humans
Mammals
Models, Animal
Muscle, Skeletal
Neurogenesis
Orthopedics
Regeneration
Seasons
Stem Cells
Torpor

Reference

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