- Mucosal vaccine adjuvants update
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Rhee JH, Lee SE, Kim SY
- KMID: 2278788
- Clin Exp Vaccine Res.
- 2012 Jul;1(1):50-63.
- doi: 10.7774/cevr.2012.1.1.50
Mucosal vaccination, capable of inducing protective immune responses both in the mucosal and systemic immune compartments, has many advantages and is regarded as a blue ocean in the vaccine industry.... -
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- Influence of Immunity Induced at Priming Step on Mucosal Immunization of Heterologous Prime-Boost Regimens
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Eo SK
- KMID: 2150576
- Immune Netw.
- 2003 Jun;3(2):110-117.
- doi: 10.4110/in.2003.3.2.110
BACKGROUND: The usefulness of DNA vaccine at priming step of heterologous prime-boost vaccination led to DNA vaccine closer to practical reality. DNA vaccine priming followed by recombinant viral vector boosting... -
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- The development of mucosal vaccines for both mucosal and systemic immune induction and the roles played by adjuvants
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Kim SH, Jang YS
- KMID: 2366887
- Clin Exp Vaccine Res.
- 2017 Jan;6(1):15-21.
- doi: 10.7774/cevr.2017.6.1.15
Vaccination is the most successful immunological practice that improves the quality of human life and health. Vaccine materials include antigens of pathogens and adjuvants potentiating the effectiveness of vaccination. Vaccines... -
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- Recent progress in mucosal immunology and vaccine development
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Kweon MN
- KMID: 2155351
- Exp Mol Med.
- 2014 Mar;46(3):e86.
- doi: 10.1038/emm.2014.2
No abstract available. -
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- Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity
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Shim BS, Choi Y, Cheon IS, Song MK
- KMID: 2150770
- Immune Netw.
- 2013 Jun;13(3):81-85.
- doi: 10.4110/in.2013.13.3.81
The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing... -
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- Inactivated pep27 mutant as an effective mucosal vaccine against a secondary lethal pneumococcal challenge in mice
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Choi SY, Tran TD, Briles DE, Rhee DK
- KMID: 2391977
- Clin Exp Vaccine Res.
- 2013 Jan;2(1):58-65.
PURPOSE: A pep27 mutant may be able to elicit mucosal immunity against pneumococcal diseases, and could be employed as an inexpensive attenuated vaccine. However, this particular mutant contains an erythromycin-resistance... -
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- Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination
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Kim SH, Lee KY, Jang YS
- KMID: 2150745
- Immune Netw.
- 2012 Oct;12(5):165-175.
- doi: 10.4110/in.2012.12.5.165
Vaccination is one of the most effective methods available to prevent infectious diseases. Mucosa, which are exposed to heavy loads of commensal and pathogenic microorganisms, are one of the first... -
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- Mucosal dendritic cells shape mucosal immunity
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Chang SY, Ko HJ, Kweon MN
- KMID: 2155349
- Exp Mol Med.
- 2014 Mar;46(3):e84.
- doi: 10.1038/emm.2014.16
Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that... -
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- Gut Microbiota in Inflammatory Bowel Disease
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Shim JO
- KMID: 1428802
- Pediatr Gastroenterol Hepatol Nutr.
- 2013 Mar;16(1):17-21.
- doi: 10.5223/pghn.2013.16.1.17
The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along... -
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- Expression of the ATP-gated P2X7 Receptor on M Cells and Its Modulating Role in the Mucosal Immune Environment
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Kim SH, Lee HY, Jang YS
- KMID: 2150829
- Immune Netw.
- 2015 Feb;15(1):44-49.
- doi: 10.4110/in.2015.15.1.44
Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by... -
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- Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines
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Kim SH, Jang YS
- KMID: 2155350
- Exp Mol Med.
- 2014 Mar;46(3):e85.
- doi: 10.1038/emm.2013.165
Vaccination is one of the most successful applications of immunology and for a long time has depended on parenteral administration protocols. However, recent studies have pointed to the promise of... -
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- A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly
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Fukuyama Y, Ikeda Y, Ohori J, Sugita G, Aso K, Fujihashi , Briles DE, McGhee JR, Fujihashi
- KMID: 2150825
- Immune Netw.
- 2015 Feb;15(1):9-15.
- doi: 10.4110/in.2015.15.1.9
Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective... -
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- N-terminal Domain of the Spike Protein of Porcine Epidemic Diarrhea Virus as a New Candidate Molecule for a Mucosal Vaccine
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Kim SH, Cho BH, Lee KY, Jang YS
- KMID: 2414556
- Immune Netw.
- 2018 Jun;18(3):e21.
- doi: 10.4110/in.2018.18.e21
Porcine epidemic diarrhea virus (PEDV) is a contagious coronavirus infecting pigs that leads to significant economic losses in the swine industry. Given that PEDV infection occurs in gut epithelial cells... -
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- HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
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Shui JW, Kronenberg M
- KMID: 2168016
- Immune Netw.
- 2014 Apr;14(2):67-72.
- doi: 10.4110/in.2014.14.2.67
The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent... -
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- Targeted Delivery of VP1 Antigen of Foot-and-mouth Disease Virus to M Cells Enhances the Antigen-specific Systemic and Mucosal Immune Response
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Kim SH, Lee HY, Jang YS
- KMID: 2150781
- Immune Netw.
- 2013 Aug;13(4):157-162.
- doi: 10.4110/in.2013.13.4.157
Application of vaccine materials through oral mucosal route confers great economical advantage in animal farming industry due to much less vaccination cost compared with that of injection-based vaccination. In particular,... -
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- Eosinophils are Required for Immune Responses Induced by Oral Immunization
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Jung Y
- KMID: 2168719
- J Bacteriol Virol.
- 2015 Dec;45(4):354-363.
- doi: 10.4167/jbv.2015.45.4.354
Eosinophils are multifunctional leukocytes that reside in several tissues, most abundantly in the small intestinal lamina propria under the steady state. To date, the phenotypic and functional characteristics of small... -
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- Evaluation of systemic and mucosal immune responses in mice administered with novel recombinant Salmonella vaccines for avian pathogenic Esherichia coli
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Oh IG, Lee JH
- KMID: 1790565
- Korean J Vet Res.
- 2013 Dec;53(4):199-205.
Avian pathogenic Escherichia coli (APEC) is a causative agent for a number of extra intestinal diseases and account for significant losses to the poultry industry. Since protective immunity against APEC... -
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- Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with beta2-adrenergic agonist
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Kim SB, Han YW, Rahman MM, Kim SJ, Yoo DJ, Kang SH, Kim K, Eo SK
- KMID: 1122282
- Exp Mol Med.
- 2009 Nov;41(11):812-823.
- doi: 10.3858/emm.2009.41.11.087
Cholera toxin, which has been frequently used as mucosal adjuvant, leads to an irreversible activation of adenylyl cyclase, thereby accumulating cAMP in target cells. Here, it was assumed that beta2-adrenergic... -
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- Enhancing mucosal immunity in mice by recombinant adenovirus expressing major epitopes of porcine circovirus-2 capsid protein delivered with cytosine-phosphate-guanosine oligodeoxynucleotides
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Chang HT, He XY, Liu YF, Chen L, Guo QH, Yu QY, Zhao J, Wang XW, Yang X, Wang CQ
- KMID: 2155623
- J Vet Sci.
- 2014 Sep;15(3):399-407.
- doi: 10.4142/jvs.2014.15.3.399
A recombinant replication-defective adenovirus expressing the major epitopes of porcine circovirus-2 (PCV-2) capsid protein (rAd/Cap/518) was previously constructed and shown to induce mucosal immunity in mice following intranasal delivery. In... -
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- Mucosal Immune Responses of Mice Experimentally Infected with Pygidiopsis summa (Trematoda: Heterophyidae)
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Chai JY, Park YJ, Park JH, Jung BK, Shin EH
- KMID: 1715667
- Korean J Parasitol.
- 2014 Feb;52(1):27-33.
- doi: 10.3347/kjp.2014.52.1.27
Mucosal immune responses against Pygidiopsis summa (Trematoda: Heterophyidae) infection were studied in ICR mice. Experimental groups consisted of group 1 (uninfected controls), group 2 (infection with 200 metacercariae), and group... -
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