Exp Mol Med.  2014 Mar;46(3):e84. 10.1038/emm.2014.16.

Mucosal dendritic cells shape mucosal immunity

Affiliations
  • 1Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, Korea. sychang@ajou.ac.kr
  • 2Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
  • 3Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea.

Abstract

Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells. On the basis of their molecular expression, DCs can be divided into several subsets with unique functions. In this review, we focus on intestinal DC subsets and their function in bridging the innate signaling and adaptive immune systems to maintain the homeostasis of the intestinal immune environment. We also review the current strategies for manipulating mucosal DCs for the development of efficient mucosal vaccines to protect against infectious diseases.

Keyword

antigen capture; helper T-cell subset; mucosal dendritic cells; mucosal vaccine; secretory IgA
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