- Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis
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Kim JW
- KMID: 1717321
- Korean J Hepatol.
- 2010 Sep;16(3):278-279.
- doi: 10.3350/kjhep.2010.16.3.278
No abstract available. -
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- Regulatory Role of Hypoxia Inducible Factor in the Biological Behavior of Nucleus Pulposus Cells
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Li H, Liang CZ, Chen QX
- KMID: 2158211
- Yonsei Med J.
- 2013 Jul;54(4):807-812.
- doi: 10.3349/ymj.2013.54.4.807
Intervertebral disc (IVD) degeneration is implicated as a major cause of low back pain. The alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization... -
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- Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy
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Yu T, Tang B, Sun X
- KMID: 2419104
- Yonsei Med J.
- 2017 May;58(3):489-496.
- doi: 10.3349/ymj.2017.58.3.489
Hypoxia is frequently observed in solid tumors and also one of the major obstacles for effective cancer therapies. Cancer cells take advantage of their ability to adapt hypoxia to initiate... -
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- Role of HIF1α Regulatory Factors in Stem Cells
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Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Han HJ
- KMID: 2447220
- Int J Stem Cells.
- 2019 Mar;12(1):8-20.
- doi: 10.15283/ijsc18109
Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that induces the transcription of genes involved in the metabolism and behavior of stem cells. HIF1-mediated adaptation to hypoxia is required... -
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- Functional Role of a Conserved Sequence Motif in the Oxygen-dependent Degradation Domain of Hypoxia-inducible Factor 1 alpha in the Recognition of p53
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Chi SW
- KMID: 2166342
- Genomics Inform.
- 2008 Jun;6(2):72-76.
Hypoxia-inducible factor 1 alpha (HIF1 alpha) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation... -
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- Wheatgrass extract inhibits hypoxia-inducible factor-1-mediated epithelial-mesenchymal transition in A549 cells
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Do NY, Shin HJ, Lee JE
- KMID: 2412019
- Nutr Res Pract.
- 2017 Apr;11(2):83-89.
- doi: 10.4162/nrp.2017.11.2.83
BACKGROUND/OBJECTIVES: Epithelial-mesenchymal transition (EMT) is involved in not only cancer development and metastasis but also non-cancerous conditions. Hypoxia is one of the proposed critical factors contributing to formation of chronic... -
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- The Histological Changes and Expression of Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor according to the Differential Renal Function during Total Ureteral Obstruction in the Rabbit Model
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Shim KS, Lee KM, Lee SD, Kim IJ, Kim JY
- KMID: 1997114
- Korean J Urol.
- 2007 Apr;48(4):444-451.
- doi: 10.4111/kju.2007.48.4.444
PURPOSE: The renal histological and hemodynamic changes and the expressions of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) were evaluated according to the differential renal function (DRF)... -
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- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- The Expression of Hypoxia Inducible Factor-1alpha and Its Correlation with the Expressions of Cyclin A1 and Cyclin B1 and the Clinicopathologic Factors of Uterine Cervical Carcinoma
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Pyo JY, Cho JH, Kim H, Park JP, Kim YT, Cho NH
- KMID: 1472549
- Korean J Pathol.
- 2009 Feb;43(1):13-19.
- doi: 10.4132/KoreanJPathol.2009.43.1.13
BACKGROUND: Hypoxia inducible factor-1alpha(HIF-1alpha) is a transcription factor for various target genes that are involved in adapting cells to hypoxia. It promotes cell proliferation and survival via modulation of such... -
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- Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
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Peng J, Wang X, Ran L, Song J, Luo R, Wang Y
- KMID: 2421366
- J Breast Cancer.
- 2018 Sep;21(3):259-266.
- doi: 10.4048/jbc.2018.21.e42
PURPOSE: The transforming growth factor β1 (TGF-β1)/SMAD family member 3 (SMAD3) pathway, and hypoxia-inducible factor 1α (HIF-1α) are two key players in various types of malignancies including breast cancer. The... -
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- Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors
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Chen L, Endler A, Shibasaki
- KMID: 1099861
- Exp Mol Med.
- 2009 Dec;41(12):849-857.
- doi: 10.3858/emm.2009.41.12.103
The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are modulated by several pro- and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have been established as the basic and major inducers... -
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- Increased Expression of Hypoxia-Inducible Factor-1alpha in Castrated Rat Penile Tissue
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Yang DY, Lee WK, Kim KW, Seo CD, Lee YG, Kim H, Kim SY, Park HW, Cho SJ
- KMID: 2298703
- Korean J Androl.
- 2004 Aug;22(2):75-80.
PURPOSE: Hypoxia-inducible factor 1(HIF-1) is a transcriptional activator of genes whose products are involved in systemic, local, and cellular responses to hypoxia. We investigated the effect of androgen deprivation on... -
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- Penile Expression of Hypoxia-inducible Factor-1alpha, Vascular Endothelial Growth Factor, and Nitric Oxide Synthase in the Type II Diabetic Rat
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Park HJ, Park BK, Park NC
- KMID: 2226644
- Korean J Androl.
- 2005 Dec;23(3):144-152.
PURPOSE: Erectile dysfunction(ED) is commonly experienced in men with diabetes mellitus. Hypoxia in the penile tissue by vascular complications is regarded as a pathophysiologic factor in diabetic ED. The aim... -
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- Urinary Hypoxia-Inducible Factor-1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis
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Ma C, Wei J, Zhan F, Wang R, Fu K, Wan X, Li Z
- KMID: 1776995
- Yonsei Med J.
- 2012 May;53(3):587-592.
- doi: 10.3349/ymj.2012.53.3.587
PURPOSE: Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular... -
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- The Effect of HIF-1alpha siRNA on Growth and Chemosensitivity of Mia-paca Cell Line
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Yang L, Kang WK
- KMID: 1084504
- Yonsei Med J.
- 2008 Apr;49(2):295-300.
- doi: 10.3349/ymj.2008.49.2.295
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) primarily mediates the hypoxic response. HIF-1alpha induction by various stimuli contributes to cell proliferation and survival. To investigate the effect of HIF-1alpha, we used small interfering... -
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- Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1
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Chang W, Lee CY, Park JH, Park MS, Maeng LS, Yoon CS, Lee MY, Hwang KC, Chung YA
- KMID: 1482815
- J Vet Sci.
- 2013 Mar;14(1):69-76.
- doi: 10.4142/jvs.2013.14.1.69
The use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction. However, the poor viability of MSCs after transplantation critically limits the efficacy of... -
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- Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1alpha in a Rat Model of Bronchopulmonary Dysplasia
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Choi CW, Lee J, Lee HJ, Park HS, Chun YS, Kim BI
- KMID: 2344155
- J Korean Med Sci.
- 2015 Sep;30(9):1295-1301.
- doi: 10.3346/jkms.2015.30.9.1295
Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants... -
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- Expression of Hypoxia-inducible Factor-1alpha and Vascular Endothelial Growth Factor in Corpus Cavernosum of the Type 2 Diabetes Mellitus Rat
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Lee WK, Ko KT, Lee SW, Seo CD, Kim SY, Kim H, Yang DY, Kim DM
- KMID: 2226660
- Korean J Androl.
- 2005 Apr;23(1):24-29.
PURPOSE: The expression of hypoxia-inducible factor-1alpha(HIF-1alpha) and vascular endothelial growth factor(VEGF) has been known as important factor of vascular complications in diabetes mellitus. The penile tumescence has variable degree according... -
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- Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
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Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ
- KMID: 1503899
- Yonsei Med J.
- 2013 Mar;54(2):374-380.
- doi: 10.3349/ymj.2013.54.2.374
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated... -
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- Regulation of glucose metabolism-related genes and VEGF by HIF-1alpha and HIF-1beta, but not HIF-2alpha, in gastric cancer
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Song IS, Wang AG, Yoon SY, Kim JM, Kim JH, Lee DS, Kim NS
- KMID: 756286
- Exp Mol Med.
- 2009 Jan;41(1):51-58.
- doi: 10.3858/emm.2009.41.1.007
Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution... -
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