- Prediction of Cancer Incidence and Mortality in Korea, 2022
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Jung KW, Won YJ, Kang MJ, Kong HJ, Im JS, Seo HG
- KMID: 2528204
- Cancer Res Treat.
- 2022 Apr;54(2):345-351.
- doi: 10.4143/crt.2022.179
Purpose This study aimed to report the projected cancer incidence and mortality for the year 2022 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2019... -
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- Validation of Cancer Diagnosis Based on the National Health Insurance Service Database versus the National Cancer Registry Database in Korea
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Yang MS, Park M, Back JH, Lee GH, Shin JH, Kim K, Seo HJ, Kim YA
- KMID: 2528205
- Cancer Res Treat.
- 2022 Apr;54(2):352-361.
- doi: 10.4143/crt.2021.044
Purpose This study aimed to assess the feasibility of operational definitions of cancer patients in conducting cancer-related studies using the claims data from the National Health Insurance Service (NHIS). Materials and... -
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- Challenges in the Use of Targeted Therapies in Non–Small Cell Lung Cancer
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Rivera-Concepcion J, Uprety D, Adjei AA
- KMID: 2528202
- Cancer Res Treat.
- 2022 Apr;54(2):315-329.
- doi: 10.4143/crt.2022.078
Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing... -
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- Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2019
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Kang MJ, Won YJ, Lee JJ, Jung KW, Kim HJ, Kong HJ, Im JS, Seo HG, The Community of Population-Based Regional Cancer Registries
- KMID: 2528203
- Cancer Res Treat.
- 2022 Apr;54(2):330-344.
- doi: 10.4143/crt.2022.128
Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2019. Materials and Methods Incidence, survival, and prevalence rates of cancer were... -
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- Effectiveness of Concomitant Chemoradiotherapy with Gemcitabine in Locally Advanced Cervical Cancer Patients with Comorbidities
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Brau-Figueroa H, Arango-Bravo E, Castro-Eguiluz D, Galicia-Carmona T, Lugo-Alferez LA, Cruz-Bautista I, Jiménez-Lima R, Cetina-Pérez L
- KMID: 2528224
- Cancer Res Treat.
- 2022 Apr;54(2):554-562.
- doi: 10.4143/crt.2021.375
Purpose The standard treatment for locally advanced cervical cancer (LACC) is concomitant chemoradiotherapy with cisplatin (CDDP) followed by brachytherapy. The presence of comorbidities are risk factors for nephrotoxicity and are associated... -
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- Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults
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Ju HY, Park M, Lee JA, Park HJ, Park SY, Kim JH, Kang HG, Yang HC, Park BK
- KMID: 2528225
- Cancer Res Treat.
- 2022 Apr;54(2):563-571.
- doi: 10.4143/crt.2021.178
Purpose No standard salvage regimen is available for relapsed or refractory sarcoma. We investigated the efficacy and toxicity of the vincristine, irinotecan, and temozolomide combination (VIT) for relapsed or refractory... -
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- Comparison of the Effectiveness and Clinical Outcome of Everolimus Followed by CDK4/6 Inhibitors with the Opposite Treatment Sequence in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer
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Jeong H, Jeong JH, Kim JE, Ahn JH, Jung KH, Kim SB
- KMID: 2528216
- Cancer Res Treat.
- 2022 Apr;54(2):469-477.
- doi: 10.4143/crt.2021.205
Purpose In hormone receptor-positive, human epidermal growth factor receptor 2–negative metastatic breast cancer (HR+ HER2–MBC), the mainstay treatment options include cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and everolimus (EVE) in combination... -
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- Histone Deacetylase as a Valuable Predictive Biomarker and Therapeutic Target in Immunotherapy for Non-Small Cell Lung Cancer
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Shin HS, Choi J, Lee J, Lee SY
- KMID: 2528215
- Cancer Res Treat.
- 2022 Apr;54(2):458-468.
- doi: 10.4143/crt.2021.425
Purpose Histone deacetylase inhibitors (HDACis) are epigenetic regulators and used clinically for hematopoietic malignancies. Recently, HDACis have received attention as a factor that modulates the immune system. In this study,... -
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- A Real-world Efficacy of Nab-paclitaxel Monotherapy in Metastatic Breast Cancer
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Kim JS, Suh KJ, Lee DW, Woo Gu, Kim M, Kim SH, Ryu HS, Lee KH, Kim TY, Han SW, Park SY, Park IA, Kim JH, Im SA
- KMID: 2528218
- Cancer Res Treat.
- 2022 Apr;54(2):488-496.
- doi: 10.4143/crt.2021.394
Purpose We aimed to assess the real-world efficacy of nab-paclitaxel in metastatic breast cancer patients. Materials and Methods This is a retrospective study performed in two tertiary referral hospitals in Korea. Patients with... -
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- Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer
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Seo HR, Nam AR, Bang JH, Oh KS, Kim JM, Yoon J, Kim TY, Oh DY
- KMID: 2528223
- Cancer Res Treat.
- 2022 Apr;54(2):541-553.
- doi: 10.4143/crt.2021.473
Purpose Up to 20% of patients with biliary tract cancer (BTC) have alterations in DNA damage response (DDR) genes, including homologous recombination (HR) genes. Therefore, the DDR pathway could be... -
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- miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37
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Kim MS, Kim SH, Yang SH, Kim MS
- KMID: 2528214
- Cancer Res Treat.
- 2022 Apr;54(2):445-457.
- doi: 10.4143/crt.2021.622
Purpose With the identification of epidermal growth factor receptor (EGFR) mutations in non–small cell lung cancer (NSCLC) cells, EGFR–tyrosine kinase inhibitors (TKIs) are being used widely as the first-line of treatment... -
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- Attitudes toward Risk-Reducing Mastectomy and Risk-Reducing Salpingo-oophorectomy among Young, Unmarried, Healthy Women in Korea
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Park B, Kim D, Kim J, Lee BY, Yoon J, Kim SW
- KMID: 2528207
- Cancer Res Treat.
- 2022 Apr;54(2):375-382.
- doi: 10.4143/crt.2021.449
Purpose This study investigated the attitudes toward risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) as cancer prevention options for BRCA1/2 carriers in healthy, young, unmarried Korean women. Materials and Methods A... -
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- A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis
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Zeng J, Xiao Xq, Zhou Zy
- KMID: 2528222
- Cancer Res Treat.
- 2022 Apr;54(2):525-540.
- doi: 10.4143/crt.2021.373
Purpose Emerging evidence has shown that SKP1-cullin-1-F-box-protein (SCF) E3 ligases contribute to the pathogenesis of different cancers by mediating the ubiquitination and degradation of tumor suppressors. However, the functions of SCF... -
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- Incidence Patterns and Outcomes of Ewing Sarcoma in South Korea (1999-2017): A Retrospective Analysis Using Korea Central Cancer Registry Data
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Lee JA, Lim J, Park D, Jin HY, Park M, Park HJ, Park JW, Kim JH, Kang HG, Won YJ
- KMID: 2528228
- Cancer Res Treat.
- 2022 Apr;54(2):590-596.
- doi: 10.4143/crt.2021.311
Purpose Due to low incidence, epidemiologic data of Ewing sarcoma in the Asian population are scarce. We aimed to examine the incidence pattern and outcome of patients with Ewing sarcoma in... -
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- Clinicopathologic Characteristics and Clinical Outcome of Localized Liposarcoma: A Single-Center Experience over 25 Years and Evaluation of PD-L1 Expression
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Chae H, Kim JE, Kim W, Lee JS, Song SY, Lee MH, Chung HW, Cho KJ, Song JS, Ahn JH
- KMID: 2528227
- Cancer Res Treat.
- 2022 Apr;54(2):579-589.
- doi: 10.4143/crt.2021.496
Purpose For liposarcoma (LPS), clinical course and proper treatment strategies have not been well-established. Recently, immune-checkpoint inhibitors have shown potential efficacy in LPS. We aimed to describe the clinical course... -
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- Machine Learning Model for Predicting Postoperative Survival of Patients with Colorectal Cancer
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Osman MH, Mohamed RH, Sarhan HM, Park EJ, Baik SH, Lee KY, Kang J
- KMID: 2528221
- Cancer Res Treat.
- 2022 Apr;54(2):517-524.
- doi: 10.4143/crt.2021.206
Purpose Machine learning (ML) is a strong candidate for making accurate predictions, as we can use large amount of data with powerful computational algorithms. We developed a ML based model... -
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- Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study)
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Ahn GS, Hwang K, Kim TM, Park CK, Chang JH, Jung TY, Kim JH, Nam DH, Kim SH, Yoo H, Hong YK, Kim EY, Lee DE, Joo J, Kim YJ, Choe G, Choi BS, Kang SG, Kim JH, Kim CY
- KMID: 2528209
- Cancer Res Treat.
- 2022 Apr;54(2):396-405.
- doi: 10.4143/crt.2021.393
Purpose The KNOG-1101 study showed improved 2-year PFS with temozolomide during and after radiotherapy compared to radiotherapy alone for patients with anaplastic gliomas. This trial investigates the effect of concurrent and... -
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- Engineering a High-Affinity PD-1 Peptide for Optimized Immune Cell-Mediated Tumor Therapy
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Chen Y, Huang H, Liu Y, Wang Z, Wang L, Wang Q, Zhang Y, Wang H
- KMID: 2528206
- Cancer Res Treat.
- 2022 Apr;54(2):362-374.
- doi: 10.4143/crt.2021.424
Purpose The purpose of this study was to optimize a peptide (nABP284) that binds to programmed cell death protein 1 (PD-1) by a computer-based protocol in order to increase its affinity.... -
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- Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect
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Akagunduz OO, Yilmaz SG, Tavlayan E, Baris ME, Afrashi F, Esassolak M
- KMID: 2528211
- Cancer Res Treat.
- 2022 Apr;54(2):417-423.
- doi: 10.4143/crt.2021.575
Purpose This study aimed to evaluate the radiation-induced adverse effects on ocular structures in head and neck cancer patients and investigate the radiation dose-volume effects on the cornea, lacrimal gland,... -
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- Plasma Circulating Tumor DNA in Patients with Primary Central Nervous System Lymphoma
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Yoon SE, Kim YJ, Shim JH, Park D, Cho J, Ko YH, Park WY, Mun YC, Lee KE, Cho D, Kim WS, Kim SJ
- KMID: 2528229
- Cancer Res Treat.
- 2022 Apr;54(2):597-612.
- doi: 10.4143/crt.2021.752
Purpose Analysis of circulating tumor DNA (ctDNA) in blood could allow noninvasive genetic analysis of primary tumors. Although there have been unmet needs for noninvasive methods in patients with primary central... -
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