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MicroRNA-10b Plays a Role in Bone Formation by Suppressing Interleukin-22 in Ankylosing Spondylitis

Park PR, Jo S, Jin SH, Kim TJ

OBJECTIVE: The microRNA (miR)-10b is the T helper (Th) 17 cell specific in patients with ankylosing spondylitis (AS). The interleukin (IL)-22, which is closely related to Th17 cells, has been...
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Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients

Chang Y, Kim J, Woo HG, Ryu DR, Oh HJ, Song TJ

BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is associated with atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization. This study aimed to determine the association of the plasma...
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Tumor-induced osteomalacia

Yin Z, Du J, Yu F, Xia W

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic syndrome characterized by hypophosphatemia resulting from decreased tubular phosphate reabsorption, with a low or inappropriately normal level of...
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Multiple Sequential Physeal Injuries with Vitamin D Deficiency

Kim BK, Kim YG, Lee HJ, Choi DS, Dan J

Vitamin D plays a major role in bone metabolism, and its deficiency has an impact on fracture risk and healing. Low vitamin D levels are a cause of poor bone...
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Cellular zinc deficiency inhibits the mineralized nodule formation and downregulates bone-specific gene expression in osteoblastic MC3T3-E1 cells

Cho YE, Kwun IS

PURPOSE: Zinc (Zn) is an essential trace element for bone mineralization and osteoblast function. We examined the effects of Zn deficiency on osteoblast differentiation and mineralization in MC3T3-E1 cells. METHODS: Osteoblastic...
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School-based exercise interventions effectively increase bone mineralization in children and adolescents

Nguyen VH

Osteoporosis and fragility fractures have become major global public health concerns, and they can be prevented by maximizing peak bone mass during childhood and adolescence with weight-bearing physical activity, which...
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Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Mansouritorghabeh H, Rezaieyazdi Z

Bleeding disorders, including hemophilia, can be seen in every ethnic population in the world. Among various bleeding disorders, reduced bone density has been addressed in hemophilia A. In recent years,...
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Melanin extract from Gallus gallus domesticus promotes proliferation and differentiation of osteoblastic MG-63 cells via bone morphogenetic protein-2 signaling

Yoo HS, Chung KH, Lee KJ, Kim DH, An JH

BACKGROUND/OBJECTIVES: Gallus gallus domesticus (GD) is a natural mutant breed of chicken in Korea with an atypical characterization of melanin in its tissue. This study investigated the effects of melanin...
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Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

Kim JS, Cha JK, Lee JS, Choi SH, Cho KS

PURPOSE: The purpose of the present study was to evaluate the effectiveness of a minimal concentration of bone morphogenetic protein-2 (BMP-2) in terms of quantitative and qualitative analyses of newly...
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Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin

Lee KY, Choi HS, Choi HS, Chung KY, Lee BJ, Maeng HJ, Seo MD

The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various...
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Changes of calcific density in pediatric patients with testicular microlithiasis

Lim B, Song SH, Song G, Kim KS

PURPOSE: Testicular microlithiasis (TM) is a relatively rare clinical entity of controversial significance characterized by the existence of hydroxyapatite microliths located in the seminiferous tubules. The aim of this study...
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A Case of Low Bone Mineral Density with Vitamin D Deficiency Due to Prolonged Lactation and Severe Malnutrition

Shin MY, Kang YE, Kong SE, Ju SH, Back MK, Kim KS

Malnutrition associated vitamin D deficiency contributes to the calcium loss from bone and results in osteoporosis and osteomalacia at final stage. Osteomalacia is characterized with softening of bone secondary to...
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Vitamin D status and childhood health

Shin YH, Shin HJ, Lee YJ

Vitamin D is an essential component of bone and mineral metabolism; its deficiency causes growth retardation and skeletal deformities in children and osteomalacia and osteoporosis in adults. Hypovitaminosis D (vitamin...
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A Case of Nutritional Osteomalacia in Young Adult Male

Noh CK, Lee MJ, Kim BK, Chung YS

Vitamin D is an important hormone that can be a role of bone and calcium metabolism in the human organ. Thus, vitamin D deficiency could contribute to the severity of...
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Regulation of osteogenic differentiation of human adipose-derived stem cells by controlling electromagnetic field conditions

Kang KS, Hong JM, Kang JA, Rhie JW, Jeong YH, Cho DW

  • KMID: 2154225
  • Exp Mol Med.
  • 2013 Jan;45(1):e6.
Many studies have reported that an electromagnetic field can promote osteogenic differentiation of mesenchymal stem cells. However, experimental results have differed depending on the experimental and environmental conditions. Optimization of...
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1-34 PTH Could Reverse Impaired Bone Mineralization Induced By the Overdose of Bisphosphonate

Park KH, Kim KJ, Choi HS, Kim KM, Lee EY, Han S, Kim HS, Kim D, Seok H, Choe EY, Rhee Y, Lim SK

Bisphosphonates are the mainstay of osteoporosis treatment. Despite the fact that bisphosphonates have a relatively good safety record and are tolerated well by the majority of patients, serious adverse events...
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Comparing the osteogenic potential of canine mesenchymal stem cells derived from adipose tissues, bone marrow, umbilical cord blood, and Wharton's jelly for treating bone defects

Kang BJ, Ryu HH, Park SS, Koyama Y, Kikuchi M, Woo HM, Kim WH, Kweon OK

Alternative sources of mesenchymal stem cells (MSCs) for replacing bone marrow (BM) have been extensively investigated in the field of bone tissue engineering. The purpose of this study was to...
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May Long Term Oxcarbazepine Treatment Be Lead to Secondary Hyperparathyroidism?

Babacan O, Karaoglu A, Vurucu S, Yesilkaya , Yesilyurt , Cayci T, Gulgun M, Unay B, Akin R, Ozcan O

BACKGROUND AND PURPOSE: The adverse effects of newer antiepileptic drugs are not well-known. This study assessed the impact of oxcarbazepine (OXC) treatment on bone turnover. METHODS: Forty-four children with idiopathic focal...
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Using 18F-FDG PET/CT to Detect an Occult Mesenchymal Tumor Causing Oncogenic Osteomalacia

Seo HJ, Choi YJ, Kim HJ, Jeong YH, Cho A, Lee JH, Yun M, Lee JD, Kang WJ

  • KMID: 1447603
  • Nucl Med Mol Imaging.
  • 2011 Sep;45(3):233-237.
Oncogenic osteomalacia is a rare paraneoplastic syndrome characterized by renal phosphate excretion, hypophosphatemia, and osteomalacia. This syndrome is often caused by tumors of mesenchymal origin. Patients with oncogenic osteomalacia have...
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Radiological Features of Soft Tissue Calcification: A Pictorial Essay

Lee YS

Calcification of soft tissue may represent a nonspecific local response or be a manifestation of underlying disease. The diagnosis and principle of treatment varies depending on the characteristics of the...
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