J Bone Metab.  2013 May;20(1):51-55. 10.11005/jbm.2013.20.1.51.

A Case of Nutritional Osteomalacia in Young Adult Male

• Noh CK
• Lee MJ
• Kim BK
• Chung YS

• KMID: 2286314
• DOI: http://doi.org/10.11005/jbm.2013.20.1.51

Abstract

Vitamin D is an important hormone that can be a role of bone and calcium metabolism in the human organ. Thus, vitamin D deficiency could contribute to the severity of metabolic bone disease. The osteomalacia, one of the metabolic bone diseases, is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available phosphorus and calcium. We experienced a case of osteomalacia presented with walking disturbance, 30 year-old young aged man, caused by vitamin D deficiency due to strict vegetarian diet and lack of sunlight exposures.

Keyword

Osteomalacia; Vitamin D; Vegetarian

MeSH Terms

Aged
Bone Diseases, Metabolic
Calcification, Physiologic
Calcium
Diet, Vegetarian
Humans
Male
Osteomalacia
Phosphorus
Sunlight
Vitamin D
Vitamin D Deficiency
Walking
Young Adult
Calcium
Phosphorus
Vitamin D

Figure

• 

  Fig. 1 Bone densitometry study revealed significant low bone mass in lumbar spine and femur.

• 

  Fig. 2 Multiple increased uptakes in ribs and pelvis suggesting metabolic bone disease including osteomalacia.

Reference

1. Kasper DL. Longo DL, Kasper DL, Jameson JL, editors. Endocrinology and metabolism. Harrison's principles of internal medicine. 2012. 18th ed. New York: The McGraw-Hill Companies, Inc;5590–7080.

2. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004. 80:1678S–1688S.

3. Hodgkin P, Hine PM, Kay GH, et al. Vitamin-D deficiency in Asians at home and in Britain. Lancet. 1973. 2:167–171.

4. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988. 67:373–378.

5. Scharla S. Diagnosis of disorders of vitamin D-metabolism and osteomalacia. Clin Lab. 2008. 54:451–459.

6. Kim HS, Jung HS, Kim HJ, et al. A case of tumor-induced osteomalacia with elevated fibroblast growth factor-23. J Korean Endocr Soc. 2007. 22:142–148.

7. Park YK. Oncogenic osteomalacia. Korean J Pathol. 2006. 40:1–8.

8. Kim HS, Kim DS, Choi NW, et al. A case of osteomalacia with long term carbamazepine therapy. J Korean Soc Endocrinol. 2000. 15:286–290.

9. Nam JH, Choi GH, Park KH, et al. A case of adult fanconi's syndrome with glomerular podocyte foot process effacement and osteomalacia induced by k light chain disease. J Korean Soc Endocrinol. 2000. 15:627–633.

10. Kim SY, Rhee SY, Moon SY, et al. A case of osteomalacia caused by severe vitamin D deficiency. J Korean Endocr Soc. 2007. 22:55–61.

11. Myung DS, Kim MH, Chung JO, et al. A case of osteomalacia due to vitamin D deficiency in a 36-year-old woman. Korean J Med. 2009. 77:S128–S133.