- Long-Lasting Antiandrogen Withdrawal Syndrome in Castration-Resistant Prostate Cancer: Three Cases With Complete Response
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Kim SJ, Ryu JH, Kim YB, Jung TY
- KMID: 2439401
- Korean J Urol Oncol.
- 2018 Apr;16(1):38-41.
- doi: 10.22465/kjuo.2018.16.1.38
This is a case report of 3 patients who had a dramatic and long-term complete response after antiandrogen withdrawal. All 3 patients were diagnosed with advanced or metastatic prostate cancer... -
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- Current Concepts in Androgen Deprivation Therapy
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Hong JH, Choi HY
- KMID: 2137875
- J Korean Med Assoc.
- 2004 May;47(5):408-416.
- doi: 10.5124/jkma.2004.47.5.408
The hormonal sensitivity of prostate cancer has been exploited clinically since Huggins and Hodges established the suppressive effects of castration on prostate cancer. Despite over sixty years of research into... -
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- Role of Androgen Receptor in Prostate Cancer: A Review
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Fujita K, Nonomura N
- KMID: 2455406
- World J Mens Health.
- 2019 Sep;37(3):288-295.
- doi: 10.5534/wjmh.180040
Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding domain, hinge region, and ligand-binding domain. AR plays... -
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- Drug Therapy: What It Means to the Dermatologist and to the Patient
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Maddin S
- KMID: 2146618
- Korean J Dermatol.
- 1986 Apr;24(2):173-180.
The current treatment of acne vulgaris utilizing both topical and systemic agents i eviewed. New therapeutic agents such as the retinoids and their newer analogus etretin and RO-15-0778, antiandrogens cyproterone... -
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- Efficacy of Alternative Antiandrogen Therapy for Prostate Cancer That Relapsed after Initial Maximum Androgen Blockade
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Choi JI, Kim YB, Yang SO, Lee JK, Jung TY
- KMID: 2315439
- Korean J Urol.
- 2011 Jul;52(7):461-465.
PURPOSE: We evaluated the effectiveness of second-line maximum androgen blockade (MAB) with an alternative antiandrogen in patients who relapsed after initial MAB. MATERIALS AND METHODS: We retrospectively analyzed 47 patients with... -
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- Adjuvant Effect of IV Clodronate on the Delay of Bone Metastasis in High-Risk Prostate Cancer Patients: A Prospective Study
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Rodrigues , Hering FO, Meller A
- KMID: 2167565
- Cancer Res Treat.
- 2011 Dec;43(4):231-235.
PURPOSE: High-risk prostate cancer patients undergoing treatment often experience biochemical recurrence. The use of bisphosphonates as an adjuvant treatment delays skeletal events, yet whether or not bisphosphonates also delay metastastic... -
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- Nonmetastatic Castration-Resistant Prostate Cancer
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Hong JH, Kim IY
- KMID: 1988417
- Korean J Urol.
- 2014 Mar;55(3):153-160.
- doi: 10.4111/kju.2014.55.3.153
After the introduction of prostate cancer screening with the prostate-specific antigen (PSA) test, we have witnessed a dramatic stage migration. As a result, an increasing number of patients are diagnosed... -
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- Androgen deprivation therapy is associated with decreased second primary lung cancer risk in the United States veterans with prostate cancer
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Jung K, Park JC, Kang H, Brandes JC
- KMID: 2438494
- Epidemiol Health.
- 2018;40:e2018040.
- doi: 10.4178/epih.e2018040
OBJECTIVES: We investigated whether androgen deprivation therapy (ADT) in prostate cancer patients was associated with a decreased risk for second primary lung cancer in US veterans. METHODS: Prostate cancer diagnoses in... -
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- Prognostic Significance of Prostate-specific Antigen Level Two Months after Maximal Androgen Blockade in Metastatic Prostate Cancer
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Park BJ, Lee YG, Ahn HK
- KMID: 2293544
- Korean J Urol.
- 2003 Sep;44(9):855-860.
PURPOSE: The aim of this study was to analyze the prognostic significance of pre- and post-treatment serum prostate-specific antigen (PSA) level, together with a variety of other clinicopathological parameters, in... -
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- Hypersexuality in Dementia
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Cheon JS
- KMID: 2186208
- J Korean Geriatr Psychiatry.
- 2003 Jun;7(1):76-82.
PURPOSE: Hypersexual behavior such as increased libido, change in sexual orientation or disinhibition had been reported in dementia. Mechanism and treatment measures were reviewed. METHOD: A medline search was undertaken... -
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- A Prostate Carcinoma Metastasized to Bilateral Breasts
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Cho HJ, Lee ES, Park JS, Bae JY, Park SH
- KMID: 1873046
- Korean J Urol.
- 2005 Jan;46(1):96-99.
Antiandrogens are generally used for the treatment of prostate cancer, with gynecomastia the most common adverse event seen during therapy. However, a breast mass in a man with a carcinoma... -
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- Primary Androgen Deprivation Therapy for Prostate Cancer in Koreans: A Retrospective Multicenter Study
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Seo WI, Kang PM, Kim TH, Moon KH, Chung JM, Lee DH, Kim IY, Min K, Chung J, Kim W, Kang DI
- KMID: 2320780
- World J Mens Health.
- 2014 Dec;32(3):159-166.
- doi: 10.5534/wjmh.2014.32.3.159
PURPOSE: To evaluate the characteristics of patients who received primary androgen deprivation therapy (PADT) for prostate cancer and the clinical efficacy of this treatment. MATERIALS AND METHODS: Two hundred forty patients... -
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- Exponential Rise in Prostate-Specific Antigen (PSA) during Anti-Androgen Withdrawal Predicts PSA Flare after Docetaxel Chemotherapy in Patients with Castration-Resistant Prostate Cancer
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Han KS, Hong SJ
- KMID: 2070012
- Yonsei Med J.
- 2015 Mar;56(2):368-374.
- doi: 10.3349/ymj.2015.56.2.368
PURPOSE: To investigate the relationship between rising patterns of prostate-specific antigen (PSA) before chemotherapy and PSA flare during the early phase of chemotherapy in patients with castration-resistant prostate cancer (CRPC). MATERIALS... -
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- Metabolic effects of androgen deprivation therapy
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Choi SM, Kam SC
- KMID: 2070264
- Korean J Urol.
- 2015 Jan;56(1):12-18.
- doi: 10.4111/kju.2015.56.1.12
The therapeutic effects and side effects of androgen deprivation therapy (ADT), which is a main treatment method for metastatic prostate cancer, are well known, but the metabolic effects have only... -
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- Influence of Androgen Deprivation Therapy on the Uptake of PSMA-Targeted Agents: Emerging Opportunities and Challenges
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Bakht MK, Oh SW, Youn H, Cheon GJ, Kwak C, Kang KW
- KMID: 2396577
- Nucl Med Mol Imaging.
- 2017 Sep;51(3):202-211.
- doi: 10.1007/s13139-016-0439-4
Prostate-specific membrane antigen (PSMA) is an attractive target for both diagnosis and therapy because of its high expression in the vast majority of prostate cancers. Development of small molecules for... -
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- Medical Treatment of the Benign Prostatic Hyperplasia
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Chang SG
- KMID: 1936472
- J Korean Med Assoc.
- 2004 Feb;47(2):163-172.
- doi: 10.5124/jkma.2004.47.2.163
The search for nonhormonal pharmacological agents capable of reducing out flow obstruction caused by benign prostatic hyperplasia (BPH) began in the 1970s when alpha adrenergic receptors were demonstrated within the... -
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- The effect of continuous androgen deprivation treatment on prostate cancer patients as compared with intermittent androgen deprivation treatment
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Ku JY, Lee JZ, Ha HK
- KMID: 2344111
- Korean J Urol.
- 2015 Oct;56(10):689-694.
- doi: 10.4111/kju.2015.56.10.689
PURPOSE: To investigate the efficacy of androgen deprivation treatment (ADT) between continuous and intermittent ADT. MATERIALS AND METHODS: Between January 2006 and May 2015, 603 patients were selected and divided into... -
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- Unrecognized Kinetics of Serum Testosterone: Impact on Short-Term Androgen Deprivation Therapy for Prostate Cancer
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Koo KC, Lee DH, Kim KH, Lee SH, Hong CH, Hong SJ, Chung BH
- KMID: 2068664
- Yonsei Med J.
- 2014 May;55(3):570-575.
- doi: 10.3349/ymj.2014.55.3.570
PURPOSE: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa),... -
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- Effect of antiandrogens upon the morphological development of gubernaculum and the testicular descent in rats
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Han SW, Lee HY, Yang WI, Choi SK
- KMID: 2036828
- Korean J Urol.
- 1992 Apr;33(2):239-249.
We evaluated the effect of antiandrogens on both fetal and adult rats, noting especially the morphological changes in the gubernaculum and testicular descent. Two antiandrogens, flutamide and 5a-reductase inhibitor 4-methyl-4-aza-5-pregnane-3-one-20[s] carboxylate... -
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- Effects of statin use on the response duration to androgen deprivation therapy in metastatic prostate cancer
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Jung J, Lee C, Lee C, Kwon T, You D, Jeong IG, Hong JH, Ahn H, Kim CS
- KMID: 2344101
- Korean J Urol.
- 2015 Sep;56(9):630-636.
- doi: 10.4111/kju.2015.56.9.630
PURPOSE: To determine whether statin use delays the development of castration-resistant prostate cancer (CRPC) in patients with metastatic prostate cancer treated with androgen deprivation therapy (ADT). MATERIALS AND METHODS: A total... -
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