Korean J Urol Oncol.  2018 Apr;16(1):38-41. 10.22465/kjuo.2018.16.1.38.

Long-Lasting Antiandrogen Withdrawal Syndrome in Castration-Resistant Prostate Cancer: Three Cases With Complete Response

• Kim SJ
• Ryu JH
• Kim YB
• Jung TY

• KMID: 2439401
• DOI: http://doi.org/10.22465/kjuo.2018.16.1.38

Abstract

This is a case report of 3 patients who had a dramatic and long-term complete response after antiandrogen withdrawal. All 3 patients were diagnosed with advanced or metastatic prostate cancer with a high prostate-specific antigen (PSA) level. For all patients, we started combined androgen blockade as androgen deprivation therapy and the PSA concentration decreased to <0.1 ng/mL, but then started to increase. After discontinuation of antiandrogen the PSA concentration decreased again and has remained below the limit of sensitivity for more than 1 year in all 3 patients.

Keyword

Androgen antagonists; Androgen deprivation therapy; Antiandrogen withdrawal syndrome; Castration resistant prostatic neoplasms; Complete response

MeSH Terms

Androgen Antagonists
Humans
Prostate*
Prostate-Specific Antigen
Prostatic Neoplasms*
Prostatic Neoplasms, Castration-Resistant
Androgen Antagonists
Prostate-Specific Antigen