- Folate and Homocysteine Levels during Pregnancy affect DNA Methylation in Human Placenta
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Park BH, Kim YJ, Park JS, Lee HY, Ha EH, Min JW, Park HS
- KMID: 792375
- J Prev Med Public Health.
- 2005 Nov;38(4):437-442.
OBJECTIVES: DNA methylation is one of the best characterized epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. In this present study, we investigated the... -
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- Identification of DNA methylation associated gene signatures in endometrial cancer via integrated analysis of DNA methylation and gene expression systematically
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Men C, Chai H, Song X, Li Y, Du H, Ren Q
- KMID: 2413209
- J Gynecol Oncol.
- 2017 Nov;28(6):e83.
- doi: 10.3802/jgo.2017.28.e83
OBJECTIVE: Endometrial cancer (EC) is a common gynecologic cancer worldwide. However, the pathogenesis of EC has not been epigenetically elucidated. Here, this study aims to describe the DNA methylation profile... -
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- Detection of Aberrant p16INK4A Methylation in Sera of Patients with Liver Cirrhosis and Hepatocellular Carcinoma
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Chu HJ, Heo J, Seo SB, Kim GH, Kang DH, Song GA, Cho M, Yang US
- KMID: 1785699
- J Korean Med Sci.
- 2004 Feb;19(1):83-86.
- doi: 10.3346/jkms.2004.19.1.83
Hepatocellular carcinomas (HCCs) show genomic alterations, including DNA rearrangements associated with HBV DNA integration, loss of heterozygosity, and chromosomal amplification. The genes most frequently involved are those encoding tumor suppressors.... -
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- Methylation Pattern of DNA Repair Genes and Microsatellite Instability in Hepatocelluar Carcinoma
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Park JH, Cho SB, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Lee JH, Kim SJ
- KMID: 1113480
- Korean J Gastroenterol.
- 2006 Nov;48(5):327-336.
BACKGROUND/AIMS: Epigenetic silencing of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT), hMLH1 and hMSH3, by promoter hypermethylation have been observed in various cancers. However, the relationship between hypermethylation of DNA... -
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- Hypermethylation of Tumor-related Genes in Genitourinary Cancer Cell Lines
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Chung WB, Hong SH, Kim JA, Sohn YK, Kim BW, Kim JW
- KMID: 648358
- J Korean Med Sci.
- 2001 Dec;16(6):756-761.
- doi: 10.3346/jkms.2001.16.6.756
Hypermethylation of CpG island is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed 13 genitourinary cancer cell lines for aberrant DNA methylation of... -
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- Methylation Profiles of CpG Island Loci in Major Types of Human Cancers
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Park SY, Kim BH, Kim JH, Cho NY, Choi M, Yu EJ, Lee S, Kang GH
- KMID: 1713193
- J Korean Med Sci.
- 2007 Apr;22(2):311-317.
- doi: 10.3346/jkms.2007.22.2.311
Several reports have described aberrant methylation in various types of human cancers. However, the interpretation of methylation frequency in various human cancers has some limitations because of the different materials... -
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- The role of promoter methylation in Epstein-Barr virus (EBV) microRNA expression in EBV-infected B cell lines
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Kim DN, Song YJ, Lee SK
- KMID: 1015459
- Exp Mol Med.
- 2011 Jul;43(7):401-410.
- doi: 10.3858/emm.2011.43.7.044
Epstein-Barr virus (EBV) microRNAs (miRNAs) are expressed in EBV-associated tumors and cell lines, but the regulation mechanism of their expression is unclear yet. We investigated whether the expression of EBV... -
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- Differential Methylation Pattern of ID4, SFRP1, and SHP1 between Acute Myeloid Leukemia and Chronic Myeloid Leukemia
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Uhm KO, Lee ES, Lee YM, Park JS, Kim SJ, Kim BS, Kim HS, Park SH
- KMID: 1779169
- J Korean Med Sci.
- 2009 Jun;24(3):493-497.
- doi: 10.3346/jkms.2009.24.3.493
To gain insight into the differential mechanism of gene promoter hypermethylation in acute and chronic leukemia, we identified the methylation status on one part of 5'CpG rich region of 8... -
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- Overexpression of Mucin 13 due to Promoter Methylation Promotes Aggressive Behavior in Ovarian Cancer Cells
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Sung HY, Park AK, Ju W, Ahn JH
- KMID: 1799482
- Yonsei Med J.
- 2014 Sep;55(5):1206-1213.
- doi: 10.3349/ymj.2014.55.5.1206
PURPOSE: Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are... -
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- CpG Island Methylation in Familial Colorectal Cancer Patients Not Fulfilling the Amsterdam Criteria
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Kim HC, Lee HJ, Roh SA, Kim JS, Yu CS, Kim JC
- KMID: 1713460
- J Korean Med Sci.
- 2008 Apr;23(2):270-277.
- doi: 10.3346/jkms.2008.23.2.270
To determine the role of methylation in colorectal cancer patients with a family history, we enrolled 25 colorectal cancer patients with a family history of colorectal cancer but without a... -
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- Level of HOXA5 Hypermethylation in Acute Myeloid Leukemia is Associated with Short-term Outcome
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Kim SY, Hwang SH, Song EJ, Shin HJ, Jung JS, Lee EY
- KMID: 1022036
- Korean J Lab Med.
- 2010 Oct;30(5):469-473.
- doi: 10.3343/kjlm.2010.30.5.469
Hypermethylation of the homeobox (HOX) gene promoter leads to decreased expression of the gene during tumor development and is thought to be correlated with the clinical outcome in leukemia. In... -
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- Genotype-specific methylation of HPV in cervical intraepithelial neoplasia
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Hsu YW, Huang RL, Su PH, Chen YC, Wang HC, Liao CC, Lai HC
- KMID: 2413439
- J Gynecol Oncol.
- 2017 Jul;28(4):e56.
- doi: 10.3802/jgo.2017.28.e56
OBJECTIVE: Hypermethylation of human papillomavirus (HPV) and host genes has been reported in cervical cancer. However, the degree of methylation of different HPV types relative to the severity of the... -
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- Identification of Novel Methylation Markers in Hepatocellular Carcinoma using a Methylation Array
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Shin SH, Kim BH, Jang JJ, Suh KS, Kang GH
- KMID: 1714035
- J Korean Med Sci.
- 2010 Aug;25(8):1152-1159.
- doi: 10.3346/jkms.2010.25.8.1152
Promoter CpG island hypermethylation has become recognized as an important mechanism for inactivating tumor suppressor genes or tumor-related genes in human cancers of various tissues. Gene inactivation in association with... -
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- Can we use methylation markers as diagnostic and prognostic indicators for bladder cancer?
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Kim YJ, Kim WJ
- KMID: 2426519
- Investig Clin Urol.
- 2016 Jun;57(Suppl 1):S77-S88.
- doi: 10.4111/icu.2016.57.S1.S77
Urothelial carcinomas of the urinary bladder have diverse biological and functional characteristics, and numerous factors are likely to be involved in recurrence, progression, and patient survival. While several molecular markers... -
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- DNA Methylation and Expression Patterns of Key Tissue-specific Genes in Adult Stem Cells and Stomach Tissues
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Hong SJ, Kang MI, Oh JH, Jung YC, Kim YH, Kim SJ, Choi SH, Seo EJ, Choi SW, Rhyu MG
- KMID: 1782016
- J Korean Med Sci.
- 2009 Oct;24(5):918-929.
- doi: 10.3346/jkms.2009.24.5.918
CpG-island margins and non-island-CpG sites round the transcription start sites of CpG-island-positive and -negative genes are methylated to various degrees in a tissue-specific manner. These methylation-variable CpG sites were analyzed... -
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- Aberrant Hypomethylation of Solute Carrier Family 6 Member 12 Promoter Induces Metastasis of Ovarian Cancer
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Sung HY, Yang SD, Park AK, Ju W, Ahn JH
- KMID: 2374185
- Yonsei Med J.
- 2017 Jan;58(1):27-34.
- doi: 10.3349/ymj.2017.58.1.27
PURPOSE: Ovarian cancer (OC) is the most fatal of gynecological malignancies with a high rate of recurrence. We aimed to evaluate the expression of solute carrier family 6, member 12... -
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- DNA Methylation Patterns of Ulcer-Healing Genes Associated with the Normal Gastric Mucosa of Gastric Cancers
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Hong SJ, Oh JH, Jung YC, Kim YH, Kim SJ, Kang SJ, Seo EJ, Choi SW, Kang MI, Rhyu MG
- KMID: 1778036
- J Korean Med Sci.
- 2010 Mar;25(3):405-417.
- doi: 10.3346/jkms.2010.25.3.405
Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy... -
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- DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells
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Sung HY, Ju W, Ahn JH
- KMID: 2070216
- Yonsei Med J.
- 2014 Nov;55(6):1656-1663.
- doi: 10.3349/ymj.2014.55.6.1656
PURPOSE: Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads... -
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- Coordinated change of a ratio of methylated H3-Iysine 4 or acetylated H3 to acetylated H4 and DNA methylation is associated with tissue-specific gene expression in cloned pig
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Kang JK, Park KW, Chung YG, You JS, Kim YK, Lee SH, Hong SP, Choi KM, Heo KN, Seol JG, Lee JH, Jin DI, Park CS, Seo JS, Lee HW, Han JW
- KMID: 1103684
- Exp Mol Med.
- 2007 Feb;39(1):84-96.
Various cell types in higher multicellular organisms are genetically homogenous, but are functionally and morphologically heterogeneous due to the differential expression of genes during development, which appears to be controlled... -
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- Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture
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Choi MR, In YH, Park J, Park T, Jung KH, Chai JC, Chung MK, Lee YS, Chai YG
- KMID: 1387361
- Exp Mol Med.
- 2012 Aug;44(8):503-512.
Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a tendency to lose their proliferative potential, homing ability and telomere length but also genetic or epigenetic... -
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