Biomol Ther.  2019 Nov;27(6):562-569. 10.4062/biomolther.2019.061.

Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter

• Zhen AX
• Piao MJ
• Kang KA
• Madushan Fernando PDS
• Kang HK
• Koh YS
• Yi JM
• Hyun JW

• KMID: 2462883
• DOI: http://doi.org/10.4062/biomolther.2019.061

Abstract

Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM(2.5)) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and protein, mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM(2.5)-induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM(2.5), as well block the PM(2.5)-induced oxidation of molecules, such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM(2.5)-induced accumulation of cellular Ca²âº, which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM(2.5)-induced oxidative stress and cell damage.

Keyword

Niacinamide; Particulate matter 2.5; Oxidative stress; Human HaCaT keratinocyte

MeSH Terms

Antioxidants
Apoptosis
Cell Membrane
DNA
Humans
Keratinocytes
Mitochondrial Proteins
Niacinamide*
Oxidative Stress*
Particulate Matter*
Reactive Oxygen Species
Skin Diseases
Skin*
Vitamins
Antioxidants
DNA
Mitochondrial Proteins
Niacinamide
Particulate Matter
Reactive Oxygen Species
Vitamins