Korean J Pediatr.  2019 Jan;62(1):22-29. 10.3345/kjp.2018.07045.

Particulate matter and childhood allergic diseases

• Yang SI

• KMID: 2437590
• DOI: http://doi.org/10.3345/kjp.2018.07045

Abstract

Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics. This review discusses the effect of PM on childhood allergic diseases, along with plausible mechanisms. Further studies are required to understand the role of PM exposure on childhood allergic diseases, to reduce these diseases in children.

Keyword

Particulate matter; Asthma; Allergy; Child

MeSH Terms

Allergens
Asthma
Child
Dermatitis, Atopic
Epigenomics
Humans
Hypersensitivity
Oxidative Stress
Particulate Matter*
Public Health
Rhinitis, Allergic
Allergens
Particulate Matter