Allergy Asthma Respir Dis.  2019 Jul;7(3):116-121. 10.4168/aard.2019.7.3.116.

PM(2.5) and pediatric asthma

• Hwang YH
• Kim SW

• KMID: 2461403
• DOI: http://doi.org/10.4168/aard.2019.7.3.116

Abstract

Air pollution does harm to the respiratory tracts. Fine particulate matter (PM(2.5)) attacks the lung directly passing through mucosal ciliary clearance, causes new-onset asthma, or exacerbates asthma symptoms in children. Oxidative stresses, immunologic changes, allergic sensitization, and epigenetic modification are associated with bronchial asthma. Furthermore, it causes respiratory tract infection and lung function decline. We have to protect the children who are more vulnerable to PM(2.5) than adults. We will investigate individual exposure, influences by the components of air pollution, and genetic susceptibility.

Keyword

Air pollution; Asthma; Child; Particulate matter

MeSH Terms

Adult
Air Pollution
Asthma*
Child
Epigenomics
Genetic Predisposition to Disease
Humans
Lung
Oxidative Stress
Particulate Matter
Respiratory System
Respiratory Tract Infections
Particulate Matter

Figure

• 

  Fig. 1. The classification of particulate matter (PM).

• 

  Fig. 2. The mechanism of fine particulate matter induces bronchial asthma. PEFR, peak expiratory flow rate.

Reference

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