Korean J Clin Oncol.  2019 Jun;15(1):7-14. 10.14216/kjco.19007.

Association between body composition measured by bioelectrical impedance analysis and platelet-to-lymphocyte ratio in colorectal cancer

Affiliations
  • 1Department of Medicine, Keimyung University School of Medicine, Daegu, Korea.
  • 2Department of Surgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. sabiston0000@hanmail.net
  • 3Nutrition Support Team, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Abstract

PURPOSE
This study investigated the relationship between body composition and platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC).
METHODS
This retrospective study included 110 patients who underwent anthropometric measurement by bioelectrical impedance analysis before surgical treatment for CRC between May 2015 and June 2018.
RESULTS
According to PLR, 45 patients (40.9%) had low PLR (PLR<150), and 65 patients (59.1%) had high PLR (PLR≥150). Serum hemoglobin (P<0.001) and albumin levels (P=0.021) were significantly lower in high PLR group. Tumor mass diameter was significantly larger in high PLR group (P=0.048) and the proportion of poorly differentiated or mucinous tumors was significantly higher in high PLR group (P=0.037). All indices related to fat (body fat mass, percent body fat, body fat mass of trunk, visceral fat area, fat mass index, measured fat thickness of abdomen) and two indices related to muscle (arm muscle circumference, measured muscle circumference of abdomen) were significantly lower in high PLR group (P<0.05). According to subgroup analysis based on the sex, all indices significantly differed between PLR groups; however, in females no index was significantly different between PLR groups.
CONCLUSION
Body composition indices including fat and muscle indices measured by InBody 770 were related to PLR in CRC, especially in male patients. These results suggest that low muscle and fat indices may be related to poor prognosis of CRC.

Keyword

Colorectal neoplasm; Nutrition assessment; Body composition; Electric impedance; Prognosis

MeSH Terms

Adipose Tissue
Body Composition*
Colorectal Neoplasms*
Electric Impedance*
Female
Humans
Intra-Abdominal Fat
Male
Mucins
Nutrition Assessment
Prognosis
Retrospective Studies
Mucins
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