Immune Netw.  2019 Jun;19(3):e22. 10.4110/in.2019.19.e22.

Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer

• Ignacio RM
• Lee ES
• Son DS

• KMID: 2450207
• DOI: http://doi.org/10.4110/in.2019.19.e22

Abstract

Ovarian cancer (OC), the deadliest gynecological cancer, results in poor overall survival, urgently requiring a novel therapeutic approach. As cumulative exposures to endotoxins decreased OC risk epidemiologically, we evaluated if LPS, a Toll-like receptor 4 agonist known as active component of endotoxins, could increase survival in the murine peritoneal dissemination model of SKOV-3 OC cells. LPS significantly increased the mean survival time of more than 116 days compared with 63 days in the control. Furthermore, no tumor burden was present in three mice among eight LPS-treated mice. SKOV-3 cells were not responsive to LPS and showed unaltered chemokine signature. Rather than direct effects to OC cells, LPS was found to increase proinflammatory chemokines and cytokines, such as CXCL1, CXCL8, TNF, and IL-1B, in innate immune system. Taken together, LPS is likely to potentiate the cytotoxic-related innate immunogenicity via proinflammatory chemokines and cytokines, which attenuates the peritoneal dissemination of OC.

Keyword

Lipopolysaccharides; Chemokines; Cytokines; Innate immunity; Ovarian cancer

MeSH Terms

Animals
Chemokines
Cytokines
Endotoxins
Immune System
Immunity, Innate
Lipopolysaccharides
Mice
Ovarian Neoplasms*
Survival Rate
Toll-Like Receptor 4
Tumor Burden
Chemokines
Cytokines
Endotoxins
Lipopolysaccharides
Toll-Like Receptor 4