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Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer

Ignacio RM, Lee ES, Son DS

Ovarian cancer (OC), the deadliest gynecological cancer, results in poor overall survival, urgently requiring a novel therapeutic approach. As cumulative exposures to endotoxins decreased OC risk epidemiologically, we evaluated if...
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Association between endotoxin levels in dust from indoor swine housing environments and the immune responses of pigs

Roque K, Shin KM, Jo JH, Lim GD, Song ES, Shin SJ, Gautam R, Lee JH, Kim YG, Cho AR, Kim CY, Kim HJ, Lee MS, Oh HG, Lee BC, Kim JH, Kim KH, Jeong HK, Kim HA, Heo Y

Indoor animal husbandry environments are inevitably contaminated with endotoxins. Endotoxin exposure is associated with various inflammatory illnesses in animals. This cross-sectional study evaluated the relationship between the degree of endotoxin...
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Particulate Matter and Cognitive Function

Roh J, Jung HY, Lee KJ

The term “particulate Matter (PM)” refers to the mixture of small-sized solid particles and liquid droplets floating in the air, and is referred to as PM₁₀ ( < 10 µm),...
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The Curves Exercise Suppresses Endotoxemia in Korean Women with Obesity

Jin SA, Kim SK, Seo HJ, Kim M, Ahn KT, Kim JH, Park JH, Lee JH, Choi SW, Jeong JO

Obesity and metabolic syndrome is a worldwide pandemic and associated with high cardiovascular risk. Metabolic endotoxemia (ME) is thought to be an underlying molecular mechanism. It triggers toll-like receptor 4-mediated...
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Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats

Huang ZW, Liu N, Li D, Zhang HY, Wang Y, Liu Y, Zhang LL, Ju XL

PURPOSE: Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of endothelial permeability and leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord...
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Association of MBL With Work-Related Respiratory Symptoms in Bakery Workers

Kim MA, Yoon MK, Kim SH, Park HS

Baker's asthma is the most prevalent occupational asthma, and IgE-mediated response is known as a major pathogenesis. However, recent studies have suggested the involvement of innate immune response because wheat...
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Epizootiological characteristics of viable bacteria and fungi in indoor air from porcine, chicken, or bovine husbandry confinement buildings

Roque K, Lim GD, Jo JH, Shin KM, Song ES, Gautam R, Kim CY, Lee K, Shin S, Yoo HS, Heo Y, Kim HA

Microorganisms found in bioaerosols from animal confinement buildings not only foster the risk of spreading diseases among livestock buildings, but also pose health hazards to farm workers and nearby residents....
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Protective Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine Against Lipopolysaccharide or Polyinosinic-polycytidylic Acid-induced Acute Hepatotoxicity

Lee SY, Ko KS

BACKGROUND: Several mechanisms for the pathogenesis of many liver diseases are related with oxidative stress, endotoxins, and infections by many microorganisms. These can lead to chronic hepatitis, cirrhosis, and even...
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Use of Polymyxin B Hemoperfusion in a Patient with Septic Shock and Septic Cardiomyopathy Who Was Placed on Extracorporeal Membrane Oxygen Support

Shin SH, Lee H, Choi AJ, Chang KH, Suh GY, Chung CR

Although shock in sepsis is usually managed successfully by conventional medical treatment, a subset of cases do not respond and may require salvage therapies such as veno-arterial extracorporeal membrane oxygenation...
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Refractory Septic Shock Treated with Nephrectomy under the Support of Extracorporeal Membrane Oxygenation

Lee YK, Ryu JA, Yang JH, Park CM, Suh GY, Jeon K, Chung CR

Conventional medical therapies have not been very successful in treating adults with refractory septic shock. The effects of direct hemoperfusion using polymyxin B and veno-arterial extracorporeal membrane oxygenation (ECMO) for...
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Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects

Lee JU, Kim JD, Park CS

Over the past three decades, a large number of genetic studies have been aimed at finding genetic variants associated with the risk of asthma, applying various genetic and genomic approaches...
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Relationship between chicken cellular immunity and endotoxin levels in dust from chicken housing environments

Roque K, Shin KM, Jo JH, Kim HA, Heo Y

Hazardous biochemical agents in animal husbandry indoor environments are known to promote the occurrence of various illnesses among workers and animals. The relationship between endotoxin levels in dust collected from...
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Acute Kidney Injury: New Biomarkers

Lee S

Acute kidney injury (AKI) has various triggers, such as ischemia, nephrotoxins, radiocontrast, and bacterial endotoxins. It occurs in about one-third of patients treated in the intensive care unit. There is...
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Expression of Heat Shock Proteins and Cytokines in Response to Ethanol Induced Damage in the Small Intestine of ICR Mice

Lee SW, Choi DW, Park SC, Kim HJ, Nam YH, Choi DH, Kang CD, Lee SJ, Chun WJ, Ryu YJ

BACKGROUND/AIMS: Ethanol administration causes intestinal epithelial cell damage by increasing intestinal permeability and the translocation of endotoxins from intestinal bacterial flora. Heat shock proteins (HSPs) are associated with recovery and...
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Usefulness of the Endotoxin Activity Assay to Evaluate the Degree of Lung Injury

Sakamoto Y, Inoue S, Iwamura T, Yamashita , Nakashima , Koami H, Miike T, Yahata M, Imahase H, Goto A, Narumi S, Ohta M, Yamada CK

PURPOSE: It has been reported that the Pulse Contour Cardiac Output (PiCCO) is very useful mainly in the field of intensive care and treatment to grasp the pathophysiological conditions of...
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The Effects of Plasma Endotoxin Level on Survival Time of Terminally Ill Cancer Patients

Lee JA, Yoon HM, Choi YS, Yeon JE, Lee JY

PURPOSE: Since most terminally ill cancer patients die of multiple organ failure, plasma endotoxin concentration levels may be used to predict the life expectancy. This study was performed to evaluate...
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Effects of plasma endotoxin concentrations on the severity of atopic dermatitis in children

Kim JY, Kim EK, Lee HJ, Shin YH, Lee HK, Kim J

PURPOSE: Endotoxin exposure is associated with the development and pathogenesis of allergic diseases. The present study aimed to determine whether plasma endotoxins are elevated in children with atopic dermatitis (AD)...
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Alternaria and Alternariol Mycotoxins Affect Production of Allergic Inflammatory Cytokines in MLE12 and RAW264.7 Cells

  • KMID: 2299453
  • Korean J Asthma Allergy Clin Immunol.
  • 2012 Dec;32(4):231-238.
BACKGROUND: Alternaria and their secondary metabolites, alternariol mycotoxins, may cause respiratory symptoms and asthma. Moreover, microbial compounds, such as bacterial endotoxins, act as potential contributors in such situations. Alveolar epithelial...
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The Effect of Intestinal Permeability and Endotoxemia on the Prognosis of Acute Pancreatitis

Koh YY, Jeon WK, Cho YK, Kim HJ, Chung WG, Chon CU, Oh TY, Shin JH

  • KMID: 2167424
  • Gut Liver.
  • 2012 Oct;6(4):505-511.
BACKGROUND/AIMS: Early intestinal mucosal damage plays an important role in severe acute pancreatitis (AP). Previous studies have shown that intestinal permeability (IP), serum endotoxin and cytokines contribute to the early...
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Association of Endotoxins and Colon Polyp: A Case-Control Study

Lee KK, Yum KS

Endotoxins are known to be associated with the occurrence of various chronic diseases. This study was conducted to investigate the role of endotoxins in the pathogenesis of colon polyps through...
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