- 2-Aryl Propionic Acid Amide Modification of Naproxen and Ibuprofen Dimers for Anti-neuroinflammatory Activity in BV2 mouse Microglial Cells
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Ju H, Pachhapure S, Mufida A, Kim A, Elmaleh DR, Choi S, Jang BC
- KMID: 2536897
- Keimyung Med J.
- 2022 Dec;41(2):56-66.
- doi: 10.46308/kmj.2022.00199
Inflammation is a common link in the pathophysiology of many neurological illnesses, including Alzheimer’s disease. Activated glial cells contribute to neuroinflammation by producing pro-inflammatory mediators. Naproxen and ibuprofen are nonsteroidal... -
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- Dexmedetomidine and LPS co-treatment attenuates inflammatory response on WISH cells via inhibition of p38/NF-kB signaling pathway
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Kim TS, Yoon JY, Kim CH, Choi EJ, Kim YH, Kim EJ
- KMID: 2532221
- J Dent Anesth Pain Med.
- 2022 Aug;22(4):277-287.
- doi: 10.17245/jdapm.2022.22.4.277
Background: Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a... -
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- Gut-derived lipopolysaccharide promotes alcoholic hepatosteatosis and subsequent hepatocellular carcinoma by stimulating neutrophil extracellular traps through toll-like receptor 4
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Liu Y, Zhang X, Chen S, Wang J, Yu S, Li Y, Xu M, Aboubacar H, Li J, Shan T, Wang J, Cao G
- KMID: 2531376
- Clin Mol Hepatol.
- 2022 Jul;28(3):522-539.
- doi: 10.3350/cmh.2022.0039
Background/Aims: Binge drinking leads to many disorders, including alcoholic hepatosteatosis, which is characterized by intrahepatic neutrophil infiltration and increases the risk of hepatocellular carcinoma (HCC). Molecular mechanisms may involve the... -
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- Leaky gut-derived tumor necrosis factor-α causes sarcopenia in patients with liver cirrhosis
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Kawaguchi T, Torimura T
- KMID: 2528246
- Clin Mol Hepatol.
- 2022 Apr;28(2):177-180.
- doi: 10.3350/cmh.2021.0246
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- A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome
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Parker J, O'Brien C, Hawrelak J
- KMID: 2524681
- Obstet Gynecol Sci.
- 2022 Jan;65(1):14-28.
- doi: 10.5468/ogs.21185
Diet-induced gastrointestinal dysbiosis has been hypothesized to play a significant role in stimulating an increase in gastrointestinal permeability and activating systemic inflammation in women with polycystic ovary syndrome (PCOS). We... -
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- Inhibitory effects of fenbendazole, an anthelmintics, on lipopolysaccharide-activated mouse bone marrow cells
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Park SR, Joo HG
- KMID: 2524458
- Korean J Vet Res.
- 2021 Sep;61(3):e22.
- doi: 10.14405/kjvr.2021.61.e22
Fenbendazole (FBZ) is a commonly used anthelmintic in veterinary medicine that has recently been found to have anticancer effects in humans. On the other hand, few studies have examined the... -
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- Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases
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Anhê FF, Jensen BAH, Perazza LR, Tchernof A, Schertzer JD, Marette A
- KMID: 2516877
- J Lipid Atheroscler.
- 2021 May;10(2):129-129.
- doi: 10.12997/jla.2021.10.2.123
Gut microbes dictate critical features of host immunometabolism. Certain bacterial components and metabolites (termed postbiotics) mitigate cardiometabolic diseases whereas others potentiate pathological processes. In this review, we discuss key aspects... -
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- Irisin Regulates the Functions of Hepatic Stellate Cells
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Dong HN, Park SY, Le CT, Choi DH, Cho EH
- KMID: 2508015
- Endocrinol Metab.
- 2020 Sep;35(3):647-655.
- doi: 10.3803/EnM.2020.658
Background: Hepatic stellate cells (HSCs) are known to play a fundamental role in the progression of liver fibrosis. Once HSCs are activated, they are involved in proliferation, migration, and contractility... -
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- EphrinA1/EphA2 Promotes Epithelial Hyperpermeability Involving in Lipopolysaccharide-induced Intestinal Barrier Dysfunction
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Chen Y, Zhang L, Zhang Y, Bai T, Song J, Qian W, Hou X
- KMID: 2504009
- J Neurogastroenterol Motil.
- 2020 Jul;26(3):397-409.
- doi: 10.5056/jnm19095
Background/Aims Lipopolysaccharide (LPS) is the key factor inducing mucosal and systemic inflammation in various intestinal and parenteral diseases, which could initially disrupt the epithelial barrier function. EphrinA1/ephA2 is speculated to... -
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- Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation
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Lee S, Ju W, Tin TD, Kim J, Lee JS, Park CH, Kwak SH
- KMID: 2501821
- Korean J Anesthesiol.
- 2020 Apr;73(2):151-157.
- doi: 10.4097/kja.19233
Background: BMS-470539, a recently introduced selective agonist of the melanocortin 1 receptor, is known to have anti-inflammatory properties. In this study, we investigated the effects of BMS-470539 on lipopolysaccharide (LPS)-induced... -
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- Protective role of curcumin against lipopolysaccharide-induced inflammation and apoptosis in human neutrophil
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Cho KB, Park CH, Kim J, Tin TD, Kwak SH
- KMID: 2500453
- Anesth Pain Med.
- 2020 Jan;15(1):41-48.
- doi: 10.17085/apm.2020.15.1.41
Background: Sepsis, an uncontrolled host response to infection, may be life-threatening organ injury. Neutrophils play a critical role in regulation of host immune response to infection. Curcumin, known as a... -
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- Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats
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Lee B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2466567
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):27-37.
- doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but... -
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- Comparison of inflammatory cytokine-inducing activity of lipopolysaccharides from major periodontal bacteria
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Kim SH, Kang IC
- KMID: 2470713
- Int J Oral Biol.
- 2019 Dec;44(4):160-164.
- doi: 10.11620/IJOB.2019.44.4.160
Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) are major periodontal pathogens. Lipopolysaccharides (LPSs) from periodontal bacteria play an important role in... -
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- Effects of remifentanil preconditioning on factors related to uterine contraction in WISH cells
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Kim CH, Lee SH, Kim EJ, Ahn JH, Choi EJ, Yoon JU, Choi IS
- KMID: 2466649
- J Dent Anesth Pain Med.
- 2019 Dec;19(6):343-351.
- doi: 10.17245/jdapm.2019.19.6.343
BACKGROUND: Preterm labor and miscarriage may occur in stressful situations, such as a surgical operation or infection during pregnancy. Pharyngeal and buccal abscess and facial bone fractures are inevitable dental... -
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- Neutrophilic Granule Protein Is a Novel Murine LPS Antagonist
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Hong J, Qu P, Wuest TR, Huang H, Huang C, Lin PC
- KMID: 2461198
- Immune Netw.
- 2019 Oct;19(5):e34.
- doi: 10.4110/in.2019.19.e34
Neutrophilic granule protein (NGP) was previously reported as a granular protein of neutrophils in mouse, but the function has not been known clearly. We found the presence of the possible... -
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- Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer
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Ignacio RM, Lee ES, Son DS
- KMID: 2450207
- Immune Netw.
- 2019 Jun;19(3):e22.
- doi: 10.4110/in.2019.19.e22
Ovarian cancer (OC), the deadliest gynecological cancer, results in poor overall survival, urgently requiring a novel therapeutic approach. As cumulative exposures to endotoxins decreased OC risk epidemiologically, we evaluated if... -
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- The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury
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Jang EA, Kim JY, Tin TD, Song JA, Lee SH, Kwak SH
- KMID: 2449367
- Acute Crit Care.
- 2019 May;34(2):133-140.
- doi: 10.4266/acc.2019.00507
BACKGROUND: Overactivation of inflammatory cells, including macrophages and neutrophils, is associated with acute lung injury. BMS-470539 is a selective agonist of melanocortin 1 receptor, which triggers the inhibition of proinflammatory... -
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- Anti-inflammatory Role of Mesenchymal Stem Cells in an Acute Lung Injury Mouse Model
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Huh JW, Kim WY, Park YY, Lim CM, Koh Y, Kim MJ, Hong SB
- KMID: 2436327
- Acute Crit Care.
- 2018 Aug;33(3):154-161.
- doi: 10.4266/acc.2018.00619
BACKGROUND: Mesenchymal stem cells (MSCs) attenuate injury in various lung injury models through paracrine effects. We hypothesized that intratracheal transplantation of allogenic MSCs could attenuate lipopolysaccharide (LPS)-induced acute lung injury... -
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- Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo
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Bok E, Cho EJ, Chung ES, Shin WH, Jin BK
- KMID: 2419340
- Exp Neurobiol.
- 2018 Aug;27(4):309-319.
- doi: 10.5607/en.2018.27.4.309
The present study investigated the effects of interleukin (IL)-4 on dopamine (DA) neurons in the substantia nigra (SN) in vivo of lipopolysaccharide (LPS)-treated rat. Tyrosine hydroxylase immunohistochemistry showed a significant... -
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- Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-predominant Irritable Bowel Syndrome
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Aggarwal S, Ahuja V, Paul J
- KMID: 2417387
- J Neurogastroenterol Motil.
- 2018 Jul;24(3):422-430.
- doi: 10.5056/jnm17100
BACKGROUND/AIMS: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a prevalent functional bowel disorder. Abdominal pain, discomfort and altered intestinal habits are the salient features of IBS-D. Low grade inflammation and altered... -
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