Korean J Obstet Gynecol.  2003 Sep;46(9):1746-1753.

Expression of Chemokine Receptors in Ovarian Cancer Tissue

• Jo HJ
• Lee SY
• Park CS
• An HJ
• Oh YK
• Kim SH
• Na YJ
• Kim IH
• Lee C
• Kim SJ

Abstract

OBJECTIVE
We investigated the expression of chemokine receptors in human ovarian cancer to understand the role of chemokines in ovarian cancer development and metastasis.
METHODS
Twenty-two cases of epithelial ovarian cancer were studied for expression of 13 chemokine receptors such as CXCR1-CXCR5 and CCR1-CCR8 by using semi- quantitative RT-PCR and immunohistochemistry. Moreover, we studied the relationship between the chemokine receptors expression and lymph nodes metastasis of ovarian cancers.
RESULTS
As compared with normal ovarian tissues, ovarian cancer tissues showed higher mean expression levels of CCR1,3,4,5,7,8 and CXCR1,3,4. Of chemokine receptors, CCR7 revealed the significantly higher levels of expression in ovarian cancer tissues relative to normal tissues. In the cases of retroperitoneal lymph nodes metastasis, increased expression of CCR2,4 and CXCR 1,3,4 was observed although there was no statistical significance.
CONCLUSION
These results suggest that there is a complex chemokine/chemokine receptor network in pathogenesis and the way of lymph node metastasis of ovarian cancer rather than a specific chemokine or chemokine receptor.

Keyword

Chemokine receptors; Ovarian cancer; Tumor metastasis; Tumor development

MeSH Terms

Chemokines
Humans
Immunohistochemistry
Lymph Nodes
Neoplasm Metastasis
Ovarian Neoplasms*
Receptors, Chemokine*
Chemokines
Receptors, Chemokine