Korean J Pediatr Infect Dis.  1998 Nov;5(2):258-266. 10.14776/kjpid.1998.5.2.258.

Adenovirus Pneumonia with Respiratory Failure in Pediatric Patients

• Do SS
• Ma SH
• Park JS
• Lee YH
• Lee HJ
• Lee GM

• KMID: 2440292
• DOI: http://doi.org/10.14776/kjpid.1998.5.2.258

Abstract

PURPOSE
Cases of adenoviral penumonia with rapidly progressive clinical course were experienced. We reviewed these patients in viewpoint of clinical manifestation and adenoviral serotypes.
METHODS
Culture and indirect immunofluorescence for respiratory viruses including respiratory syncytial virus, influenza virus, parainfluenza virus, adenovirus was done with nasopharyngeal aspirates from patients who admitted due to respiratory infections in Fatima Hospital, Masan from Nov. 1996 to Jul. 1997 Cultured adenovirus was serotyped by both neutralization and hemagglutination inhibition test. Medical records were reviewed for 5 patients with respiratory failure from adenovirus was isolated and serotyped.
RESULTS
The total number of examined patients was 460 patients. We isolated respiratory viruses in 143(30.9%) patients. Adenovirus was isolated from 66 out of 143(46.2%) patients. During Jan 1997 to May 1997, five patients with ages of 18 days to 11 months who were infected by adenovirus and had high fever with dyspnea and required assisted mechanical ventilation. One patients discharged against doctor's advice then died. Two of four patients had complications of disseminated intravascular coagulation; two had bronchiolitis obliterans. Two isolates were serotype 7, and one was serotype 5, and two were untyped.
CONCLUSION
Severe pneumonia caused by serotype 7 continued to occur in 1997 following the epidemic in 1996, and severe pneumonia may also be caused by serotype 5 and other serotypes.

Keyword

Adenovirus; Pneumonia

MeSH Terms

Adenoviridae*
Bronchiolitis Obliterans
Disseminated Intravascular Coagulation
Dyspnea
Fever
Fluorescent Antibody Technique, Indirect
Hemagglutination Inhibition Tests
Humans
Medical Records
Orthomyxoviridae
Paramyxoviridae Infections
Pneumonia*
Respiration, Artificial
Respiratory Insufficiency*
Respiratory Syncytial Viruses
Respiratory Tract Infections
Serogroup