Korean J Med.  2006 Jan;70(1):94-100.

Two cases of adenovirus pneumonia treated with cidofovir

• Lee JY
• Do YS
• Ryu DR
• Park MK
• Oh WS
• Peck KR
• Song JH

Abstract

Adenovirus is one of the major viral cause of upper respiratory tract infection. Life-threatening adenovirus pneumonia is often reported in neonates, young children and immunocompromised hosts. It can rarely occur in previously healthy adults. Because there is no report on adenovirus pneumonia in adult patients in Korea, we report two cases of adenovirus pneumonia which developed in adult women. Despite of intravenous antibiotics therapy, the respiratory distress worsened and mechanical ventilation was applied. Microbiological tests for bacteria or fungi were negative. A high-resolution chest computed tomography showed bilateral patch ground-glass opacification. Subsequently, open lung biopsy specimen revealed diffuse alveolar damage and adenovirus was documented with immunohistochemical stain. Treatment with cidofovir led to prompt clinical improvement in our cases.

Keyword

Adenovirus infections; Pneumonia; Cidofovir

MeSH Terms

Adenoviridae Infections
Adenoviridae*
Adult
Anti-Bacterial Agents
Bacteria
Biopsy
Child
Female
Fungi
Humans
Immunocompromised Host
Infant, Newborn
Korea
Lung
Pneumonia*
Respiration, Artificial
Respiratory Tract Infections
Thorax
Anti-Bacterial Agents