Infect Chemother.
2021 Sep;53(3):572-577. 10.3947/ic.2020.0204.
Rapid Virologic Response to Brincidofovir in Children with Disseminated Adenovirus Infection
- Chan SY1,3
- Prockop SE
2,4 - Boulad F2,4
- Papanicolaou GA3,4
- Lee YJ3,4
- Affiliations
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- 1Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China
- 2Pediatric Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA
- 3Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
- 4Weill Cornell Medical College, Cornell University, New York, USA
- KMID: 2521252
- DOI: http://doi.org/10.3947/ic.2020.0204
Abstract
- Disseminated adenovirus infections (d-ADV) after hematopoietic cell transplant (HCT) are often fatal with limited treatment options. Brincidofovir (BCV) a lipid ester of cidofovir is developed for this indication. We report four pediatric HCT recipients with d-ADV treated successfully with BCV.
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