Infect Chemother.  2021 Sep;53(3):572-577. 10.3947/ic.2020.0204.

Rapid Virologic Response to Brincidofovir in Children with Disseminated Adenovirus Infection

Affiliations
  • 1Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China
  • 2Pediatric Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA
  • 3Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
  • 4Weill Cornell Medical College, Cornell University, New York, USA

Abstract

Disseminated adenovirus infections (d-ADV) after hematopoietic cell transplant (HCT) are often fatal with limited treatment options. Brincidofovir (BCV) a lipid ester of cidofovir is developed for this indication. We report four pediatric HCT recipients with d-ADV treated successfully with BCV.

Keyword

Brincidofovir; Antiviral treatment; Disseminated adenovirus; Hematopoietic cell transplant
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