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Rapid Virologic Response to Brincidofovir in Children with Disseminated Adenovirus Infection

Chan SY, Prockop SE, Boulad F, Papanicolaou GA, Lee YJ

Disseminated adenovirus infections (d-ADV) after hematopoietic cell transplant (HCT) are often fatal with limited treatment options. Brincidofovir (BCV) a lipid ester of cidofovir is developed for this indication. We report...
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MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician

Jin RC, Min PK, Chan SY

Since the first descriptions of their active functions more than ten years ago, small non-coding RNA species termed microRNA (miRNA) have emerged as essential regulators in a broad range of...
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Hemodynamic and Histopathologic Benefits of Early Treatment with Macitentan in a Rat Model of Pulmonary Arterial Hypertension

Kim KH, Kim HK, Chan SY, Kim YJ, Sohn DW

BACKGROUND AND OBJECTIVES: Macitentan (MAC) reduces morbidity and mortality among advanced-stage pulmonary arterial hypertension (PAH) patients. However, data regarding the histopathologic and hemodynamic benefits of MAC treatment at an early...
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