Allergy Asthma Respir Dis.  2015 Nov;3(6):402-409. 10.4168/aard.2015.3.6.402.

Clinical features of respiratory adenovirus infections in pediatric inpatients in a single medical center

• Kim TH
• Yim CH
• Ahn SY
• Kang KJ
• Choi YM
• Ko JH
• Choi KE
• Lee JH
• Lee WW

• KMID: 2218628
• DOI: http://doi.org/10.4168/aard.2015.3.6.402

Abstract

PURPOSE
The purpose of this study is to identify the epidemiologic and clinical characteristics of respiratory adenovirus infections in children, and to investigate the difference in the clinical features between single adenovirus infection and coinfection with adenovirus and other respiratory viruses.
METHODS
A retrospective study was performed in 470 children hospitalized with respiratory adenovirus infections in Gwangmyeong Sungae Hospital between January 2013 and December 2013.
RESULTS
The mean age of the patients was 46.2 months and the peak incidence was in the 12- to 24-month age group. The mean duration of hospitalization and fever were 4.5+/-1.1 and 4.5+/-9.2 days, respectively. Seasonally it had occurred throughout the year, but showed the highest prevalence in August and high prevalence in July, September, and October. The frequency of viral coinfection with other respiratory viruses was 39.6%. The age was significantly younger in coinfection group than in the single adenovirus infection group (P<0.001). The prevalence rates of bronchiolitis (P<0.001) and pneumonia (P=0.042) were significantly higher in the respiratory syncytial virus coinfection group. The coinfection rate was significantly higher in children aged less than 2 years (P<0.001), and the prevalence rates of bronchiolitis (P<0.001) and pneumonia (P<0.001) were also higher in the group aged less than 2 years than other age groups.
CONCLUSION
Adenovirus is an important viral agent in hospitalized children with acute respiratory tract infection. Lower respiratory tract infections, such as bronchiolitis and pneumonia, and coinfection with other respiratory viruses were more frequently occurred in patients under 2 years of age. Further studies are needed to clarify whether coinfection with other respiratory viruses would increase the rate of lower respiratory tract infections in patients with respiratory adenoviral infections.

Keyword

Adenovirus; Respiratory adenoviral infection; Coinfection; Child; Hospitalization

MeSH Terms

Adenoviridae Infections*
Adenoviridae*
Bronchiolitis
Child
Child, Hospitalized
Coinfection
Fever
Hospitalization
Humans
Incidence
Inpatients*
Pneumonia
Prevalence
Respiratory Syncytial Viruses
Respiratory Tract Infections
Retrospective Studies
Seasons

Figure

• 

  Fig. 1 Age distribution in children with adenoviral infection

• 

  Fig. 2 Monthly distribution in children with adenoviral infection.

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